H-41, a new minor histocompatability locus. I. Histogenetic analysis

A. Juretic, I. Vucak, B. Malenica, Z. A. Nagy, J. Klein

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Abstract

The B10.STA12 mouse congenic line inherited from the wild mouse parent not only the H-2(w13) haplotype but also an allele at a minor H locus, which we designate H-41. This allele (H-41a) differentiates the B10.STA12 line from B10.STA10 and B10.LIB55, which carry identical H-2(w13) haplotypes but a differennt H-41 allele (the H-41b, also present in the background strain C57BL/10Sn). The B10.STA12 and B10.STA10 lines reject each other's skin grafts and generate cytolytic T lymphocytes (CTL) after in vivo immunization and in vitro restimulation with cells of the partner strain. The B10.STA12 anti-B10.STA10 CTL react with B10.STA10, B10.LIB55, and B10.STA39 target cells and with cells of F1 hybrids between the responder strain B10.STA12 and strains C57BL/6, C57BL/10, C57L, BALB/c, A, AKR, WB, DBA/1, and DBA/2 but fail to react with (C3H x B10.STA12) F1 and (CBA x B10.STA12) F1 cells. The B10.STA10 anti-B10.STA12 CTL react with B10.STA12, B10.P, and C3H.NB cells but fail to react to (B6 x B10.STA10) F1 target cells. The CTL reactivity in both combinations is D(p) restricted. The B10.STA10 anti-B10.STA12 CTL exhibit, in addition, a cross-reactivity with B10.SAA48 cells that may be directed at one of the alloantigens controlled by the H-2 haplotype of this strain.

Original languageEnglish (US)
Pages (from-to)2950-2954
Number of pages5
JournalJournal of Immunology
Volume133
Issue number6
StatePublished - Dec 1 1984

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T-Lymphocytes
Haplotypes
Alleles
Congenic Mice
Isoantigens
Hybrid Cells
Immunization
Transplants
Skin
N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Juretic, A., Vucak, I., Malenica, B., Nagy, Z. A., & Klein, J. (1984). H-41, a new minor histocompatability locus. I. Histogenetic analysis. Journal of Immunology, 133(6), 2950-2954.
Juretic, A. ; Vucak, I. ; Malenica, B. ; Nagy, Z. A. ; Klein, J. / H-41, a new minor histocompatability locus. I. Histogenetic analysis. In: Journal of Immunology. 1984 ; Vol. 133, No. 6. pp. 2950-2954.
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abstract = "The B10.STA12 mouse congenic line inherited from the wild mouse parent not only the H-2(w13) haplotype but also an allele at a minor H locus, which we designate H-41. This allele (H-41a) differentiates the B10.STA12 line from B10.STA10 and B10.LIB55, which carry identical H-2(w13) haplotypes but a differennt H-41 allele (the H-41b, also present in the background strain C57BL/10Sn). The B10.STA12 and B10.STA10 lines reject each other's skin grafts and generate cytolytic T lymphocytes (CTL) after in vivo immunization and in vitro restimulation with cells of the partner strain. The B10.STA12 anti-B10.STA10 CTL react with B10.STA10, B10.LIB55, and B10.STA39 target cells and with cells of F1 hybrids between the responder strain B10.STA12 and strains C57BL/6, C57BL/10, C57L, BALB/c, A, AKR, WB, DBA/1, and DBA/2 but fail to react with (C3H x B10.STA12) F1 and (CBA x B10.STA12) F1 cells. The B10.STA10 anti-B10.STA12 CTL react with B10.STA12, B10.P, and C3H.NB cells but fail to react to (B6 x B10.STA10) F1 target cells. The CTL reactivity in both combinations is D(p) restricted. The B10.STA10 anti-B10.STA12 CTL exhibit, in addition, a cross-reactivity with B10.SAA48 cells that may be directed at one of the alloantigens controlled by the H-2 haplotype of this strain.",
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Juretic, A, Vucak, I, Malenica, B, Nagy, ZA & Klein, J 1984, 'H-41, a new minor histocompatability locus. I. Histogenetic analysis', Journal of Immunology, vol. 133, no. 6, pp. 2950-2954.

H-41, a new minor histocompatability locus. I. Histogenetic analysis. / Juretic, A.; Vucak, I.; Malenica, B.; Nagy, Z. A.; Klein, J.

In: Journal of Immunology, Vol. 133, No. 6, 01.12.1984, p. 2950-2954.

Research output: Contribution to journalArticle

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N2 - The B10.STA12 mouse congenic line inherited from the wild mouse parent not only the H-2(w13) haplotype but also an allele at a minor H locus, which we designate H-41. This allele (H-41a) differentiates the B10.STA12 line from B10.STA10 and B10.LIB55, which carry identical H-2(w13) haplotypes but a differennt H-41 allele (the H-41b, also present in the background strain C57BL/10Sn). The B10.STA12 and B10.STA10 lines reject each other's skin grafts and generate cytolytic T lymphocytes (CTL) after in vivo immunization and in vitro restimulation with cells of the partner strain. The B10.STA12 anti-B10.STA10 CTL react with B10.STA10, B10.LIB55, and B10.STA39 target cells and with cells of F1 hybrids between the responder strain B10.STA12 and strains C57BL/6, C57BL/10, C57L, BALB/c, A, AKR, WB, DBA/1, and DBA/2 but fail to react with (C3H x B10.STA12) F1 and (CBA x B10.STA12) F1 cells. The B10.STA10 anti-B10.STA12 CTL react with B10.STA12, B10.P, and C3H.NB cells but fail to react to (B6 x B10.STA10) F1 target cells. The CTL reactivity in both combinations is D(p) restricted. The B10.STA10 anti-B10.STA12 CTL exhibit, in addition, a cross-reactivity with B10.SAA48 cells that may be directed at one of the alloantigens controlled by the H-2 haplotype of this strain.

AB - The B10.STA12 mouse congenic line inherited from the wild mouse parent not only the H-2(w13) haplotype but also an allele at a minor H locus, which we designate H-41. This allele (H-41a) differentiates the B10.STA12 line from B10.STA10 and B10.LIB55, which carry identical H-2(w13) haplotypes but a differennt H-41 allele (the H-41b, also present in the background strain C57BL/10Sn). The B10.STA12 and B10.STA10 lines reject each other's skin grafts and generate cytolytic T lymphocytes (CTL) after in vivo immunization and in vitro restimulation with cells of the partner strain. The B10.STA12 anti-B10.STA10 CTL react with B10.STA10, B10.LIB55, and B10.STA39 target cells and with cells of F1 hybrids between the responder strain B10.STA12 and strains C57BL/6, C57BL/10, C57L, BALB/c, A, AKR, WB, DBA/1, and DBA/2 but fail to react with (C3H x B10.STA12) F1 and (CBA x B10.STA12) F1 cells. The B10.STA10 anti-B10.STA12 CTL react with B10.STA12, B10.P, and C3H.NB cells but fail to react to (B6 x B10.STA10) F1 target cells. The CTL reactivity in both combinations is D(p) restricted. The B10.STA10 anti-B10.STA12 CTL exhibit, in addition, a cross-reactivity with B10.SAA48 cells that may be directed at one of the alloantigens controlled by the H-2 haplotype of this strain.

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Juretic A, Vucak I, Malenica B, Nagy ZA, Klein J. H-41, a new minor histocompatability locus. I. Histogenetic analysis. Journal of Immunology. 1984 Dec 1;133(6):2950-2954.