Thirty‐five wild mice (Mus musculus L.) were captured at four different localities in Chile. The mice were typed for the presence of 15 K‐, 11 D‐, 14 A‐, and two E‐region H‐2 antigens, using the complement‐antibody microcytotoxicity assay. The mice from the sample representing the largest locality had a characteristic antigenic profile distinguishing them from other mouse populations thus far studied. With respect to class I H‐2 antigens, the profile was characterized by the presence of antigens H‐2K.16, 31, 103, 19, 108, 21, 33, 26, 115, and H‐2D.4, 106, 30, 32, 111, 114, and 18 (in order of decreasing antigen frequency), and by the absence of antigens H‐2K.15, 17, 20, 113, 116 and H‐2D.2, 9, 110, and 112. The profile was, furthermore, characterized by the relatively high frequency of antigens H‐2K.16, 31, and H‐2D.4 and 106. The profile of class II antigens was also unique to the Chilean population but less conspicuously so than that of the class I antigens. Analysis of antigenic associations suggested that among the 34% blank H‐2K alleles there were at least two coding for relatively frequent but as yet unidentified K antigens. Similarly, among the 57%blanks at the H‐2D locus there were at least two frequent alleles encoding unidentified D antigens. Analysis of genetic distances suggested similarity between South American mice and mice from coastal regions of Europe.
|Original language||English (US)|
|Number of pages||9|
|State||Published - Mar 1981|
All Science Journal Classification (ASJC) codes
- Immunology and Allergy