Habitual cigarette smoking raises pressor responses to spontaneous bursts of muscle sympathetic nerve activity

Jian Cui, Rachel C. Drew, Matthew D. Muller, Cheryl Blaha, Virginia Gonzalez, Lawrence Sinoway

Research output: Contribution to journalArticle

Abstract

Smoking is a risk factor for cardiovascular diseases. Prior reports showed a transient increase in blood pressure (BP) following a spontaneous burst of muscle sympathetic nerve activity (MSNA). We hypothesized that this pressor response would be accentuated in smokers. Using signal-averaging techniques, we examined the BP (Finometer) response to MSNA in 18 otherwise healthy smokers and 42 healthy nonsmokers during resting conditions. The sensitivities of baroreflex control of MSNA and heart rate were also assessed. The mean resting MSNA, heart rate, and mean arterial pressure (MAP) were higher in smokers than nonsmok-ers. The MAP increase following a burst of MSNA was significantly greater in smokers than nonsmokers (∆3.4 ± 0.3 vs. ∆1.6 ± 0.1 mmHg, P < 0.001). The baroreflex sensitivity (BRS) of burst inci-dence, burst area, or total activity was not different between the two groups. However, cardiac BRS was lower in smokers than nonsmokers (14.6 ± 1.7 vs. 24.6 ± 1.5 ms/mmHg, P < 0.001). Moreover, the MAP increase following a burst was negatively correlated with the cardiac BRS. These observations suggest that habitual smoking in otherwise healthy individuals raises the MAP increase following spontaneous MSNA and that the attenuated cardiac BRS in the smokers was a contributing factor. We speculate that the accentuated pressor increase in response to spontaneous MSNA may contribute to the elevated resting BP in the smokers.

Original languageEnglish (US)
Pages (from-to)R280-R288
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume317
Issue number2
DOIs
StatePublished - Aug 1 2019

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Baroreflex
Smoking
Muscles
Arterial Pressure
Blood Pressure
Heart Rate
Cardiovascular Diseases

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

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title = "Habitual cigarette smoking raises pressor responses to spontaneous bursts of muscle sympathetic nerve activity",
abstract = "Smoking is a risk factor for cardiovascular diseases. Prior reports showed a transient increase in blood pressure (BP) following a spontaneous burst of muscle sympathetic nerve activity (MSNA). We hypothesized that this pressor response would be accentuated in smokers. Using signal-averaging techniques, we examined the BP (Finometer) response to MSNA in 18 otherwise healthy smokers and 42 healthy nonsmokers during resting conditions. The sensitivities of baroreflex control of MSNA and heart rate were also assessed. The mean resting MSNA, heart rate, and mean arterial pressure (MAP) were higher in smokers than nonsmok-ers. The MAP increase following a burst of MSNA was significantly greater in smokers than nonsmokers (∆3.4 ± 0.3 vs. ∆1.6 ± 0.1 mmHg, P < 0.001). The baroreflex sensitivity (BRS) of burst inci-dence, burst area, or total activity was not different between the two groups. However, cardiac BRS was lower in smokers than nonsmokers (14.6 ± 1.7 vs. 24.6 ± 1.5 ms/mmHg, P < 0.001). Moreover, the MAP increase following a burst was negatively correlated with the cardiac BRS. These observations suggest that habitual smoking in otherwise healthy individuals raises the MAP increase following spontaneous MSNA and that the attenuated cardiac BRS in the smokers was a contributing factor. We speculate that the accentuated pressor increase in response to spontaneous MSNA may contribute to the elevated resting BP in the smokers.",
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Habitual cigarette smoking raises pressor responses to spontaneous bursts of muscle sympathetic nerve activity. / Cui, Jian; Drew, Rachel C.; Muller, Matthew D.; Blaha, Cheryl; Gonzalez, Virginia; Sinoway, Lawrence.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 317, No. 2, 01.08.2019, p. R280-R288.

Research output: Contribution to journalArticle

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T1 - Habitual cigarette smoking raises pressor responses to spontaneous bursts of muscle sympathetic nerve activity

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AU - Drew, Rachel C.

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AU - Sinoway, Lawrence

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