Hairy-Cell Leukemia

William Lipera, Lawrence D. Piro, William E. Miller, Carlos J. Carrera, Dennis A. Carson, Ernest Beutler, Robert Silber, W. Christopher Ehmann, William J. Donnelly, Mark J. Ratain, Harvey M. Golomb

Research output: Contribution to journalLetter

28 Citations (Scopus)

Abstract

To the Editor: Spiers et al. (April 2 issue) 1 reported impressive response rates in hairy-cell leukemia treated with pentostatin (2′-deoxycoformycin). Pentostatin is an inhibitor of adenosine deaminase in the pathway of purine metabolism. The authors point out that inhibition of adenosine deaminase leads to accumulation of deoxyadenosine and deoxy-ATP, both of which interfere with DNA synthesis. The malignant cell in hairy-cell leukemia contains low levels of adenosine deaminase and is sensitive to pentostatin. All the patients in this study also received allopurinol to prevent excessive uric acid formation. The authors did not, however, discuss the possible role of allopurinol in…

Original languageEnglish (US)
Pages (from-to)901-902
Number of pages2
JournalNew England Journal of Medicine
Volume317
Issue number14
DOIs
StatePublished - Oct 1 1987

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Pentostatin
Hairy Cell Leukemia
Allopurinol
Adenosine Deaminase
Adenosine Deaminase Inhibitors
Uric Acid
DNA

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Lipera, W., Piro, L. D., Miller, W. E., Carrera, C. J., Carson, D. A., Beutler, E., ... Golomb, H. M. (1987). Hairy-Cell Leukemia. New England Journal of Medicine, 317(14), 901-902. https://doi.org/10.1056/NEJM198710013171414
Lipera, William ; Piro, Lawrence D. ; Miller, William E. ; Carrera, Carlos J. ; Carson, Dennis A. ; Beutler, Ernest ; Silber, Robert ; Ehmann, W. Christopher ; Donnelly, William J. ; Ratain, Mark J. ; Golomb, Harvey M. / Hairy-Cell Leukemia. In: New England Journal of Medicine. 1987 ; Vol. 317, No. 14. pp. 901-902.
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abstract = "To the Editor: Spiers et al. (April 2 issue) 1 reported impressive response rates in hairy-cell leukemia treated with pentostatin (2′-deoxycoformycin). Pentostatin is an inhibitor of adenosine deaminase in the pathway of purine metabolism. The authors point out that inhibition of adenosine deaminase leads to accumulation of deoxyadenosine and deoxy-ATP, both of which interfere with DNA synthesis. The malignant cell in hairy-cell leukemia contains low levels of adenosine deaminase and is sensitive to pentostatin. All the patients in this study also received allopurinol to prevent excessive uric acid formation. The authors did not, however, discuss the possible role of allopurinol in…",
author = "William Lipera and Piro, {Lawrence D.} and Miller, {William E.} and Carrera, {Carlos J.} and Carson, {Dennis A.} and Ernest Beutler and Robert Silber and Ehmann, {W. Christopher} and Donnelly, {William J.} and Ratain, {Mark J.} and Golomb, {Harvey M.}",
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Lipera, W, Piro, LD, Miller, WE, Carrera, CJ, Carson, DA, Beutler, E, Silber, R, Ehmann, WC, Donnelly, WJ, Ratain, MJ & Golomb, HM 1987, 'Hairy-Cell Leukemia', New England Journal of Medicine, vol. 317, no. 14, pp. 901-902. https://doi.org/10.1056/NEJM198710013171414

Hairy-Cell Leukemia. / Lipera, William; Piro, Lawrence D.; Miller, William E.; Carrera, Carlos J.; Carson, Dennis A.; Beutler, Ernest; Silber, Robert; Ehmann, W. Christopher; Donnelly, William J.; Ratain, Mark J.; Golomb, Harvey M.

In: New England Journal of Medicine, Vol. 317, No. 14, 01.10.1987, p. 901-902.

Research output: Contribution to journalLetter

TY - JOUR

T1 - Hairy-Cell Leukemia

AU - Lipera, William

AU - Piro, Lawrence D.

AU - Miller, William E.

AU - Carrera, Carlos J.

AU - Carson, Dennis A.

AU - Beutler, Ernest

AU - Silber, Robert

AU - Ehmann, W. Christopher

AU - Donnelly, William J.

AU - Ratain, Mark J.

AU - Golomb, Harvey M.

PY - 1987/10/1

Y1 - 1987/10/1

N2 - To the Editor: Spiers et al. (April 2 issue) 1 reported impressive response rates in hairy-cell leukemia treated with pentostatin (2′-deoxycoformycin). Pentostatin is an inhibitor of adenosine deaminase in the pathway of purine metabolism. The authors point out that inhibition of adenosine deaminase leads to accumulation of deoxyadenosine and deoxy-ATP, both of which interfere with DNA synthesis. The malignant cell in hairy-cell leukemia contains low levels of adenosine deaminase and is sensitive to pentostatin. All the patients in this study also received allopurinol to prevent excessive uric acid formation. The authors did not, however, discuss the possible role of allopurinol in…

AB - To the Editor: Spiers et al. (April 2 issue) 1 reported impressive response rates in hairy-cell leukemia treated with pentostatin (2′-deoxycoformycin). Pentostatin is an inhibitor of adenosine deaminase in the pathway of purine metabolism. The authors point out that inhibition of adenosine deaminase leads to accumulation of deoxyadenosine and deoxy-ATP, both of which interfere with DNA synthesis. The malignant cell in hairy-cell leukemia contains low levels of adenosine deaminase and is sensitive to pentostatin. All the patients in this study also received allopurinol to prevent excessive uric acid formation. The authors did not, however, discuss the possible role of allopurinol in…

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Lipera W, Piro LD, Miller WE, Carrera CJ, Carson DA, Beutler E et al. Hairy-Cell Leukemia. New England Journal of Medicine. 1987 Oct 1;317(14):901-902. https://doi.org/10.1056/NEJM198710013171414