Hall of fame among pro-inflammatory cytokines

Interleukin-6 gene and its transcriptional regulation mechanisms

Yang Luo, Song Guo Zheng

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Pro-inflammatory cytokines that are generated by immune system cells and mediate many kinds of immune responses are kinds of endogenous polypeptides. They are also the effectors of the autoimmune system. It is generally accepted that interleukin (IL)-4, IL-6, IL-9, IL-17, and tumor necrosis factor-a are pro-inflammatory cytokines; however, IL-6 becomes a protagonist among them since it predominately induces pro-inflammatory signaling and regulates massive cellular processes. It has been ascertained that IL-6 is associated with a large number of diseases with inflammatory background, such as anemia of chronic diseases, angiogenesis acute-phase response, bone metabolism, cartilage metabolism, and multiple cancers. Despite great progress in the relative field, the targeted regulation of IL-6 response for therapeutic benefits remains incompletely to be understood. Therefore, it is conceivable that understanding mechanisms of IL-6 from the perspective of gene regulation can better facilitate to determine the pathogenesis of the disease, providing more solid scientific basis for clinical treatment translation. In this review, we summarize the candidate genes that have been implicated in clinical target therapy from the perspective of gene transcription regulation.

Original languageEnglish (US)
Article number604
JournalFrontiers in immunology
Volume7
Issue numberDEC
DOIs
StatePublished - Jan 1 2016

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Interleukin-6
Cytokines
Genes
Interleukin-9
Acute-Phase Reaction
Interleukin-17
Interleukin-4
Genetic Therapy
Cartilage
Anemia
Immune System
Chronic Disease
Tumor Necrosis Factor-alpha
Bone and Bones
Peptides
Therapeutics
Neoplasms

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

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Hall of fame among pro-inflammatory cytokines : Interleukin-6 gene and its transcriptional regulation mechanisms. / Luo, Yang; Zheng, Song Guo.

In: Frontiers in immunology, Vol. 7, No. DEC, 604, 01.01.2016.

Research output: Contribution to journalReview article

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AB - Pro-inflammatory cytokines that are generated by immune system cells and mediate many kinds of immune responses are kinds of endogenous polypeptides. They are also the effectors of the autoimmune system. It is generally accepted that interleukin (IL)-4, IL-6, IL-9, IL-17, and tumor necrosis factor-a are pro-inflammatory cytokines; however, IL-6 becomes a protagonist among them since it predominately induces pro-inflammatory signaling and regulates massive cellular processes. It has been ascertained that IL-6 is associated with a large number of diseases with inflammatory background, such as anemia of chronic diseases, angiogenesis acute-phase response, bone metabolism, cartilage metabolism, and multiple cancers. Despite great progress in the relative field, the targeted regulation of IL-6 response for therapeutic benefits remains incompletely to be understood. Therefore, it is conceivable that understanding mechanisms of IL-6 from the perspective of gene regulation can better facilitate to determine the pathogenesis of the disease, providing more solid scientific basis for clinical treatment translation. In this review, we summarize the candidate genes that have been implicated in clinical target therapy from the perspective of gene transcription regulation.

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