Abstract
Rabbits classically conditioned with stimulation of the pontine nuclei as a conditioned stimulus (CS) and a corneal air puff as an unconditioned stimulus (US) were injected with haloperidol (250 μg/kg). Three different stimulation CS intensity levels were used. Haloperidol administration significantly decreased the number of conditioned responses during training at all CS intensity levels with the greatest impairment seen when medium and low levels of stimulation were delivered as a CS. These results provide evidence that haloperidol disrupts classical conditioning through actions at central brain sites (i.e., sites at or efferent to the point of stimulation) and not in pathways normally involved in projecting peripheral CSs to more central locations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 233-240 |
| Number of pages | 8 |
| Journal | Life Sciences |
| Volume | 49 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1991 |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)
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Haloperidol impairs classical nictitating membrane conditioning in rabbits when stimulation of the pontine nuclei is used as a conditioned stimulus. / Gould, Thomas J.; Steinmetz, Joseph E.
In: Life Sciences, Vol. 49, No. 3, 01.01.1991, p. 233-240.Research output: Contribution to journal › Article
TY - JOUR
T1 - Haloperidol impairs classical nictitating membrane conditioning in rabbits when stimulation of the pontine nuclei is used as a conditioned stimulus
AU - Gould, Thomas J.
AU - Steinmetz, Joseph E.
PY - 1991/1/1
Y1 - 1991/1/1
N2 - Rabbits classically conditioned with stimulation of the pontine nuclei as a conditioned stimulus (CS) and a corneal air puff as an unconditioned stimulus (US) were injected with haloperidol (250 μg/kg). Three different stimulation CS intensity levels were used. Haloperidol administration significantly decreased the number of conditioned responses during training at all CS intensity levels with the greatest impairment seen when medium and low levels of stimulation were delivered as a CS. These results provide evidence that haloperidol disrupts classical conditioning through actions at central brain sites (i.e., sites at or efferent to the point of stimulation) and not in pathways normally involved in projecting peripheral CSs to more central locations.
AB - Rabbits classically conditioned with stimulation of the pontine nuclei as a conditioned stimulus (CS) and a corneal air puff as an unconditioned stimulus (US) were injected with haloperidol (250 μg/kg). Three different stimulation CS intensity levels were used. Haloperidol administration significantly decreased the number of conditioned responses during training at all CS intensity levels with the greatest impairment seen when medium and low levels of stimulation were delivered as a CS. These results provide evidence that haloperidol disrupts classical conditioning through actions at central brain sites (i.e., sites at or efferent to the point of stimulation) and not in pathways normally involved in projecting peripheral CSs to more central locations.
UR - http://www.scopus.com/inward/record.url?scp=0025847396&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025847396&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(91)90008-Y
DO - 10.1016/0024-3205(91)90008-Y
M3 - Article
C2 - 2062177
AN - SCOPUS:0025847396
VL - 49
SP - 233
EP - 240
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 3
ER -