Halothane anesthesia abolishes pulmonary vascular responses to neural antagonists

B. B. Chen, D. P. Nyhan, David Fehr, P. A. Murray

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We investigated the effects of the inhalational anesthetic halothane on autonomic nervous system (ANS) regulation of the baseline pulmonary vascular pressure-flow (P/Q̇) relationship compared with that measured in the conscious state. Multipoint pulmonary vascular P/Q̇ plots were constructed by stepwise constriction of the thoracic inferior vena cava to decrease venous return and Q̇. P/Q̇ plots were generated in the same dogs in the conscious state and during halothane anesthesia (~1.2% end tidal) in the intact (no drug) condition and after administration of selective ANS antagonists. In conscious dogs, sympathetic α1-adrenoreceptor block with prazosin decreased (P<0.01) the pulmonary vascular pressure gradient [pulmonary arterial pressure-pulmonary arterial wedge pressure (PAP-PAWP)] over the entire range of Q̇ studied; i.e., inhibition of endogenous α1-adrenoreceptor activity caused pulmonary vasodilation. In contrast, α1-adrenoreceptor block had no effect on PAP-PAWP at any value of Q̇ during halothane anesthesia. In conscious dogs, sympathetic β-adrenoreceptor block with propranolol increased (P<0.01) PAP-PAWP over the entire range of Q̇ studied; i.e., inhibition of endogenous β-adrenoreceptor activity resulted in pulmonary vasoconstriction. However, β-adrenoreceptor block had no effect on PAP-PAWP at any value of Q̇ during halothane anesthesia. Finally, cholinergic receptor block with atropine decreased (P < 0.05) PAP-PAWP at values of Q̇ > 100 ml·min-1·kg-1 in conscious dogs but had no effect on PAP-PAWP at any value of Q̇ during halothane anesthesia. These results indicate that endogenous ANS regulation of the baseline pulmonary vascular P/Q̇ relationship observed in conscious dogs is abolished during halothane anesthesia.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume262
Issue number1 31-1
StatePublished - 1992

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Halothane
Blood Vessels
Autonomic Nervous System
Anesthesia
Dogs
Lung
Prazosin
Inferior Vena Cava
Constriction
Anesthetics
Thorax
Pressure
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Physiology

Cite this

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title = "Halothane anesthesia abolishes pulmonary vascular responses to neural antagonists",
abstract = "We investigated the effects of the inhalational anesthetic halothane on autonomic nervous system (ANS) regulation of the baseline pulmonary vascular pressure-flow (P/Q̇) relationship compared with that measured in the conscious state. Multipoint pulmonary vascular P/Q̇ plots were constructed by stepwise constriction of the thoracic inferior vena cava to decrease venous return and Q̇. P/Q̇ plots were generated in the same dogs in the conscious state and during halothane anesthesia (~1.2{\%} end tidal) in the intact (no drug) condition and after administration of selective ANS antagonists. In conscious dogs, sympathetic α1-adrenoreceptor block with prazosin decreased (P<0.01) the pulmonary vascular pressure gradient [pulmonary arterial pressure-pulmonary arterial wedge pressure (PAP-PAWP)] over the entire range of Q̇ studied; i.e., inhibition of endogenous α1-adrenoreceptor activity caused pulmonary vasodilation. In contrast, α1-adrenoreceptor block had no effect on PAP-PAWP at any value of Q̇ during halothane anesthesia. In conscious dogs, sympathetic β-adrenoreceptor block with propranolol increased (P<0.01) PAP-PAWP over the entire range of Q̇ studied; i.e., inhibition of endogenous β-adrenoreceptor activity resulted in pulmonary vasoconstriction. However, β-adrenoreceptor block had no effect on PAP-PAWP at any value of Q̇ during halothane anesthesia. Finally, cholinergic receptor block with atropine decreased (P < 0.05) PAP-PAWP at values of Q̇ > 100 ml·min-1·kg-1 in conscious dogs but had no effect on PAP-PAWP at any value of Q̇ during halothane anesthesia. These results indicate that endogenous ANS regulation of the baseline pulmonary vascular P/Q̇ relationship observed in conscious dogs is abolished during halothane anesthesia.",
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Halothane anesthesia abolishes pulmonary vascular responses to neural antagonists. / Chen, B. B.; Nyhan, D. P.; Fehr, David; Murray, P. A.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 262, No. 1 31-1, 1992.

Research output: Contribution to journalArticle

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AU - Chen, B. B.

AU - Nyhan, D. P.

AU - Fehr, David

AU - Murray, P. A.

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