Hantavirus and arenavirus antibody prevalence in rodents and humans in Trentino, Northern Italy

Hannimari Kallio-Kokko, J. Laakkonen, A. Rizzoli, V. Tagliapietra, I. Cattadori, S. E. Perkins, P. J. Hudson, A. Cristofolini, W. Versini, O. Vapalahti, A. Vaheri, H. Henttonen

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Abstract

The spatial and temporal distribution of hantavirus and arenavirus antibody-positive wild rodents in Trentino, Italy, was studied using immunofluorescence assays (IFA) in two long-term sites trapped in 2000-2003, and six other sites trapped in 2002. The overall hantavirus seroprevalence in the bank voles, Clethrionomys glareolus (n=229) screened for Puumala virus (PUUV) antibodies was 0.4%, and that for Apodemus flavicollis mice (n=1416) screened for Dobrava virus (DOBV) antibodies was 0.2%. Antibodies against lymphocytic choriomeningitis virus (LCMV) were found in 82 (5.6%) of the 1472 tested rodents; the seroprevalence being 6.1% in A. flavicollis (n=1181), 3.3% i C. glareolus (n=276), and 14.3% in Microtus arvalis (n=7). Of the serum samples of 488 forestry workers studied by IFA, 12 were LCMV-IgG positive (2.5%) and one DOBV-IgG positive (0.2%), however, the latter could not be confirmed DOBV-specific with a neutralization assay. Our results show a widespread distribution but low prevalence of DOBV in Trentino, and demonstrate that the arenavirus antibodies are a common finding in several other rodent species besides the house mouse.

Original languageEnglish (US)
Pages (from-to)830-836
Number of pages7
JournalEpidemiology and Infection
Volume134
Issue number4
DOIs
StatePublished - Aug 2006

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Infectious Diseases

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    Kallio-Kokko, H., Laakkonen, J., Rizzoli, A., Tagliapietra, V., Cattadori, I., Perkins, S. E., Hudson, P. J., Cristofolini, A., Versini, W., Vapalahti, O., Vaheri, A., & Henttonen, H. (2006). Hantavirus and arenavirus antibody prevalence in rodents and humans in Trentino, Northern Italy. Epidemiology and Infection, 134(4), 830-836. https://doi.org/10.1017/S0950268805005431