Haplotype data for 23 Y-chromosome markers in a reference sample from Bosnia and Herzegovina

Lejla Kovačević, Vera Fatur-Cerić, Negra Hadžić, Jasmina Čakar, Dragan Primorac, Damir Marjanović

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Aim: To detect polymorphisms of 23 Y-chromosomal short tandem repeat (STR) loci, including 6 new loci, in a reference database of male population of Bosnia and Herzegovina, as well as to assess the importance of increasing the number of Y-STR loci utilized in forensic DNA analysis. Methods: The reference sample consisted of 100 healthy, unrelated men originating from Bosnia and Herzegovina. Sample collection using buccal swabs was performed in all geographical regions of Bosnia and Herzegovina in the period from 2010 to 2011. DNA samples were typed for 23 Y STR loci, including 6 new loci: DYS576, DYS481, DYS549, DYS533, DYS570, and DYS643, which are included in the new PowerPlex® Y 23 amplification kit. Results: The absolute frequency of generated haplotypes was calculated and results showed that 98 samples had unique Y 23 haplotypes, and that only two samples shared the same haplotype. The most polymorphic locus was DYS418, with 14 detected alleles and the least polymorphic loci were DYS389I, DYS391, DYS437, and DYS393. Conclusion: This study showed that by increasing the number of highly polymorphic Y STR markers, to include those tested in our analysis, leads to a reduction of repeating haplotypes, which is very important in the application of forensic DNA analysis.

Original languageEnglish (US)
Pages (from-to)286-290
Number of pages5
JournalCroatian Medical Journal
Issue number3
StatePublished - 2013

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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