Haplotype-specific suppression of T cell response to lactate dehydrogenase B in (responder x nonresponder)F1 mice

Z. A. Nagy, C. N. Baxevanis, J. Klein

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12 Scopus citations

Abstract

Mouse strains that express the E(k) (E(β)(k)-1(α)(k) molecule are nonresponders (NR) to the enzyme lactate dehydrogenase B (LDH(B)) in terms of T cell proliferation. Nonresponsivenss is caused by T suppressor (Ts) cells recognizing LDH(B) in the context of E(k) molecules on the antigen-presenting cells. The data presented here demonstrate that the E(k)-restricted Ts cells function in (R x NR)F1 mice in a remarkable haplotype-specific fashion: they selectively interfere with the A(k) (A(NR))-restricted response, and do not affect the response channeled through the A molecules of the responder parent. This haplotype-specificity of suppression provides an explanation for the dominance of responsiveness in (R x NR)F1 mice.

Original languageEnglish (US)
Pages (from-to)2608-2611
Number of pages4
JournalJournal of Immunology
Volume129
Issue number6
StatePublished - Dec 1 1982

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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