Harnessing catalytic pumps for directional delivery of microparticles in microchambers

Sambeeta Das, Oleg E. Shklyaev, Alicia Altemose, Henry Shum, Isamar Ortiz-Rivera, Lyanne Valdez, Thomas E. Mallouk, Anna C. Balazs, Ayusman Sen

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The directed transport of microparticles in microfluidic devices is vital for efficient bioassays and fabrication of complex microstructures. There remains, however, a need for methods to propel and steer microscopic cargo that do not require modifying these particles. Using theory and experiments, we show that catalytic surface reactions can be used to deliver microparticle cargo to specified regions in microchambers. Here reagents diffuse from a gel reservoir and react with the catalyst-coated surface. Fluid density gradients due to the spatially varying reagent concentration induce a convective flow, which carries the suspended particles until the reagents are consumed. Consequently, the cargo is deposited around a specific position on the surface. The velocity and final peak location of the cargo can be tuned independently. By increasing the local particle concentration, highly sensitive assays can be performed efficiently and rapidly. Moreover, the process can be repeated by introducing fresh reagent into the microchamber.

Original languageEnglish (US)
Article number14384
JournalNature communications
Volume8
DOIs
StatePublished - Feb 17 2017

Fingerprint

cargo
microparticles
reagents
delivery
Pumps
pumps
Lab-On-A-Chip Devices
bioassay
Bioassay
convective flow
microfluidic devices
Surface reactions
Microfluidics
Biological Assay
surface reactions
Assays
Gels
gels
catalysts
Fabrication

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Das, Sambeeta ; Shklyaev, Oleg E. ; Altemose, Alicia ; Shum, Henry ; Ortiz-Rivera, Isamar ; Valdez, Lyanne ; Mallouk, Thomas E. ; Balazs, Anna C. ; Sen, Ayusman. / Harnessing catalytic pumps for directional delivery of microparticles in microchambers. In: Nature communications. 2017 ; Vol. 8.
@article{151fe99286a84508b460f4b1f949bd7e,
title = "Harnessing catalytic pumps for directional delivery of microparticles in microchambers",
abstract = "The directed transport of microparticles in microfluidic devices is vital for efficient bioassays and fabrication of complex microstructures. There remains, however, a need for methods to propel and steer microscopic cargo that do not require modifying these particles. Using theory and experiments, we show that catalytic surface reactions can be used to deliver microparticle cargo to specified regions in microchambers. Here reagents diffuse from a gel reservoir and react with the catalyst-coated surface. Fluid density gradients due to the spatially varying reagent concentration induce a convective flow, which carries the suspended particles until the reagents are consumed. Consequently, the cargo is deposited around a specific position on the surface. The velocity and final peak location of the cargo can be tuned independently. By increasing the local particle concentration, highly sensitive assays can be performed efficiently and rapidly. Moreover, the process can be repeated by introducing fresh reagent into the microchamber.",
author = "Sambeeta Das and Shklyaev, {Oleg E.} and Alicia Altemose and Henry Shum and Isamar Ortiz-Rivera and Lyanne Valdez and Mallouk, {Thomas E.} and Balazs, {Anna C.} and Ayusman Sen",
year = "2017",
month = "2",
day = "17",
doi = "10.1038/ncomms14384",
language = "English (US)",
volume = "8",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",

}

Das, S, Shklyaev, OE, Altemose, A, Shum, H, Ortiz-Rivera, I, Valdez, L, Mallouk, TE, Balazs, AC & Sen, A 2017, 'Harnessing catalytic pumps for directional delivery of microparticles in microchambers', Nature communications, vol. 8, 14384. https://doi.org/10.1038/ncomms14384

Harnessing catalytic pumps for directional delivery of microparticles in microchambers. / Das, Sambeeta; Shklyaev, Oleg E.; Altemose, Alicia; Shum, Henry; Ortiz-Rivera, Isamar; Valdez, Lyanne; Mallouk, Thomas E.; Balazs, Anna C.; Sen, Ayusman.

In: Nature communications, Vol. 8, 14384, 17.02.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Harnessing catalytic pumps for directional delivery of microparticles in microchambers

AU - Das, Sambeeta

AU - Shklyaev, Oleg E.

AU - Altemose, Alicia

AU - Shum, Henry

AU - Ortiz-Rivera, Isamar

AU - Valdez, Lyanne

AU - Mallouk, Thomas E.

AU - Balazs, Anna C.

AU - Sen, Ayusman

PY - 2017/2/17

Y1 - 2017/2/17

N2 - The directed transport of microparticles in microfluidic devices is vital for efficient bioassays and fabrication of complex microstructures. There remains, however, a need for methods to propel and steer microscopic cargo that do not require modifying these particles. Using theory and experiments, we show that catalytic surface reactions can be used to deliver microparticle cargo to specified regions in microchambers. Here reagents diffuse from a gel reservoir and react with the catalyst-coated surface. Fluid density gradients due to the spatially varying reagent concentration induce a convective flow, which carries the suspended particles until the reagents are consumed. Consequently, the cargo is deposited around a specific position on the surface. The velocity and final peak location of the cargo can be tuned independently. By increasing the local particle concentration, highly sensitive assays can be performed efficiently and rapidly. Moreover, the process can be repeated by introducing fresh reagent into the microchamber.

AB - The directed transport of microparticles in microfluidic devices is vital for efficient bioassays and fabrication of complex microstructures. There remains, however, a need for methods to propel and steer microscopic cargo that do not require modifying these particles. Using theory and experiments, we show that catalytic surface reactions can be used to deliver microparticle cargo to specified regions in microchambers. Here reagents diffuse from a gel reservoir and react with the catalyst-coated surface. Fluid density gradients due to the spatially varying reagent concentration induce a convective flow, which carries the suspended particles until the reagents are consumed. Consequently, the cargo is deposited around a specific position on the surface. The velocity and final peak location of the cargo can be tuned independently. By increasing the local particle concentration, highly sensitive assays can be performed efficiently and rapidly. Moreover, the process can be repeated by introducing fresh reagent into the microchamber.

UR - http://www.scopus.com/inward/record.url?scp=85013218985&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85013218985&partnerID=8YFLogxK

U2 - 10.1038/ncomms14384

DO - 10.1038/ncomms14384

M3 - Article

C2 - 28211454

AN - SCOPUS:85013218985

VL - 8

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 14384

ER -

Das S, Shklyaev OE, Altemose A, Shum H, Ortiz-Rivera I, Valdez L et al. Harnessing catalytic pumps for directional delivery of microparticles in microchambers. Nature communications. 2017 Feb 17;8. 14384. https://doi.org/10.1038/ncomms14384