Health status and plasma dioxin levels in chloracne cases 20 years after the Seveso, Italy accident

A. Baccarelli, A. C. Pesatori, D. Consonni, P. Mocarelli, D. G. Patterson, N. E. Caporaso, P. A. Bertazzi, Maria Teresa Landi

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Background: The Seveso, Italy accident of 1976 exposed a large population to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or simply dioxin). The accident resulted, mostly among children, in one of the largest ever-reported outbreaks of chloracne, the typical skin disorder due to halogenated-hydrocarbon compounds. Objectives: Approximately 20 years after the accident, we conducted an epidemiological study in Seveso to investigate (a) the health status of chloracne cases; (b) TCDD-chloracne exposure-response relationship; and (c) factors modifying TCDD toxicity. Methods: From 1993 to 1998, we recruited 101 chloracne cases and 211 controls. Trained interviewers administered a structured questionnaire assessing, among other epidemiological variables, information on an extensive list of diseases. During the interview, individual pigmentary characteristics were determined. We measured plasma TCDD levels using high-resolution gas chromatography/mass spectrometry. Results Plasma TCDD was still elevated (> 10 ppt) in 78 (26.6%) of the 293 subjects with adequate plasma samples, particularly in females, in subjects who had eaten home-grown animals, and in individuals with older age, higher body mass index and residence near the accident site. After 20 years, health conditions of chloracne cases were similar to those of controls from the Seveso area. Elevated plasma TCDD was associated with chloracne [odds ratio (OR) = 3.7, 95% confidence interval (CI) 1.6-8.8, adjusted for age, sex and residence]. Chloracne risk was higher in subjects younger than 8 years at the accident (OR = 7.4, 95% CI 1.8-30.3) and, contrary to previous hypotheses, did not increase at puberty onset or in teenage years. Subjects with elevated TCDD levels and light hair colour had higher relative odds of chloracne (OR = 9.2, 95% CI 2.6-32.5). Conclusions: Dioxin toxicity in chloracne cases was confined to the acute dermatotoxic effects. Chloracne occurrence appeared related to younger age and light hair colour. Age-related dioxin elimination or dilution must be taken into account in interpreting these results.

Original languageEnglish (US)
Pages (from-to)459-465
Number of pages7
JournalBritish Journal of Dermatology
Volume152
Issue number3
DOIs
StatePublished - Mar 1 2005

Fingerprint

Chloracne
Dioxins
Italy
Health Status
Accidents
Odds Ratio
Hair Color
Confidence Intervals
Halogenated Hydrocarbons
Interviews
Light
Polychlorinated Dibenzodioxins
Puberty
Gas Chromatography-Mass Spectrometry
Disease Outbreaks
Epidemiologic Studies

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Baccarelli, A., Pesatori, A. C., Consonni, D., Mocarelli, P., Patterson, D. G., Caporaso, N. E., ... Landi, M. T. (2005). Health status and plasma dioxin levels in chloracne cases 20 years after the Seveso, Italy accident. British Journal of Dermatology, 152(3), 459-465. https://doi.org/10.1111/j.1365-2133.2005.06444.x
Baccarelli, A. ; Pesatori, A. C. ; Consonni, D. ; Mocarelli, P. ; Patterson, D. G. ; Caporaso, N. E. ; Bertazzi, P. A. ; Landi, Maria Teresa. / Health status and plasma dioxin levels in chloracne cases 20 years after the Seveso, Italy accident. In: British Journal of Dermatology. 2005 ; Vol. 152, No. 3. pp. 459-465.
@article{85a0e899883f4ab48aa274a269b25c83,
title = "Health status and plasma dioxin levels in chloracne cases 20 years after the Seveso, Italy accident",
abstract = "Background: The Seveso, Italy accident of 1976 exposed a large population to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or simply dioxin). The accident resulted, mostly among children, in one of the largest ever-reported outbreaks of chloracne, the typical skin disorder due to halogenated-hydrocarbon compounds. Objectives: Approximately 20 years after the accident, we conducted an epidemiological study in Seveso to investigate (a) the health status of chloracne cases; (b) TCDD-chloracne exposure-response relationship; and (c) factors modifying TCDD toxicity. Methods: From 1993 to 1998, we recruited 101 chloracne cases and 211 controls. Trained interviewers administered a structured questionnaire assessing, among other epidemiological variables, information on an extensive list of diseases. During the interview, individual pigmentary characteristics were determined. We measured plasma TCDD levels using high-resolution gas chromatography/mass spectrometry. Results Plasma TCDD was still elevated (> 10 ppt) in 78 (26.6{\%}) of the 293 subjects with adequate plasma samples, particularly in females, in subjects who had eaten home-grown animals, and in individuals with older age, higher body mass index and residence near the accident site. After 20 years, health conditions of chloracne cases were similar to those of controls from the Seveso area. Elevated plasma TCDD was associated with chloracne [odds ratio (OR) = 3.7, 95{\%} confidence interval (CI) 1.6-8.8, adjusted for age, sex and residence]. Chloracne risk was higher in subjects younger than 8 years at the accident (OR = 7.4, 95{\%} CI 1.8-30.3) and, contrary to previous hypotheses, did not increase at puberty onset or in teenage years. Subjects with elevated TCDD levels and light hair colour had higher relative odds of chloracne (OR = 9.2, 95{\%} CI 2.6-32.5). Conclusions: Dioxin toxicity in chloracne cases was confined to the acute dermatotoxic effects. Chloracne occurrence appeared related to younger age and light hair colour. Age-related dioxin elimination or dilution must be taken into account in interpreting these results.",
author = "A. Baccarelli and Pesatori, {A. C.} and D. Consonni and P. Mocarelli and Patterson, {D. G.} and Caporaso, {N. E.} and Bertazzi, {P. A.} and Landi, {Maria Teresa}",
year = "2005",
month = "3",
day = "1",
doi = "10.1111/j.1365-2133.2005.06444.x",
language = "English (US)",
volume = "152",
pages = "459--465",
journal = "British Journal of Dermatology",
issn = "0007-0963",
publisher = "Wiley-Blackwell",
number = "3",

}

Baccarelli, A, Pesatori, AC, Consonni, D, Mocarelli, P, Patterson, DG, Caporaso, NE, Bertazzi, PA & Landi, MT 2005, 'Health status and plasma dioxin levels in chloracne cases 20 years after the Seveso, Italy accident', British Journal of Dermatology, vol. 152, no. 3, pp. 459-465. https://doi.org/10.1111/j.1365-2133.2005.06444.x

Health status and plasma dioxin levels in chloracne cases 20 years after the Seveso, Italy accident. / Baccarelli, A.; Pesatori, A. C.; Consonni, D.; Mocarelli, P.; Patterson, D. G.; Caporaso, N. E.; Bertazzi, P. A.; Landi, Maria Teresa.

In: British Journal of Dermatology, Vol. 152, No. 3, 01.03.2005, p. 459-465.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Health status and plasma dioxin levels in chloracne cases 20 years after the Seveso, Italy accident

AU - Baccarelli, A.

AU - Pesatori, A. C.

AU - Consonni, D.

AU - Mocarelli, P.

AU - Patterson, D. G.

AU - Caporaso, N. E.

AU - Bertazzi, P. A.

AU - Landi, Maria Teresa

PY - 2005/3/1

Y1 - 2005/3/1

N2 - Background: The Seveso, Italy accident of 1976 exposed a large population to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or simply dioxin). The accident resulted, mostly among children, in one of the largest ever-reported outbreaks of chloracne, the typical skin disorder due to halogenated-hydrocarbon compounds. Objectives: Approximately 20 years after the accident, we conducted an epidemiological study in Seveso to investigate (a) the health status of chloracne cases; (b) TCDD-chloracne exposure-response relationship; and (c) factors modifying TCDD toxicity. Methods: From 1993 to 1998, we recruited 101 chloracne cases and 211 controls. Trained interviewers administered a structured questionnaire assessing, among other epidemiological variables, information on an extensive list of diseases. During the interview, individual pigmentary characteristics were determined. We measured plasma TCDD levels using high-resolution gas chromatography/mass spectrometry. Results Plasma TCDD was still elevated (> 10 ppt) in 78 (26.6%) of the 293 subjects with adequate plasma samples, particularly in females, in subjects who had eaten home-grown animals, and in individuals with older age, higher body mass index and residence near the accident site. After 20 years, health conditions of chloracne cases were similar to those of controls from the Seveso area. Elevated plasma TCDD was associated with chloracne [odds ratio (OR) = 3.7, 95% confidence interval (CI) 1.6-8.8, adjusted for age, sex and residence]. Chloracne risk was higher in subjects younger than 8 years at the accident (OR = 7.4, 95% CI 1.8-30.3) and, contrary to previous hypotheses, did not increase at puberty onset or in teenage years. Subjects with elevated TCDD levels and light hair colour had higher relative odds of chloracne (OR = 9.2, 95% CI 2.6-32.5). Conclusions: Dioxin toxicity in chloracne cases was confined to the acute dermatotoxic effects. Chloracne occurrence appeared related to younger age and light hair colour. Age-related dioxin elimination or dilution must be taken into account in interpreting these results.

AB - Background: The Seveso, Italy accident of 1976 exposed a large population to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or simply dioxin). The accident resulted, mostly among children, in one of the largest ever-reported outbreaks of chloracne, the typical skin disorder due to halogenated-hydrocarbon compounds. Objectives: Approximately 20 years after the accident, we conducted an epidemiological study in Seveso to investigate (a) the health status of chloracne cases; (b) TCDD-chloracne exposure-response relationship; and (c) factors modifying TCDD toxicity. Methods: From 1993 to 1998, we recruited 101 chloracne cases and 211 controls. Trained interviewers administered a structured questionnaire assessing, among other epidemiological variables, information on an extensive list of diseases. During the interview, individual pigmentary characteristics were determined. We measured plasma TCDD levels using high-resolution gas chromatography/mass spectrometry. Results Plasma TCDD was still elevated (> 10 ppt) in 78 (26.6%) of the 293 subjects with adequate plasma samples, particularly in females, in subjects who had eaten home-grown animals, and in individuals with older age, higher body mass index and residence near the accident site. After 20 years, health conditions of chloracne cases were similar to those of controls from the Seveso area. Elevated plasma TCDD was associated with chloracne [odds ratio (OR) = 3.7, 95% confidence interval (CI) 1.6-8.8, adjusted for age, sex and residence]. Chloracne risk was higher in subjects younger than 8 years at the accident (OR = 7.4, 95% CI 1.8-30.3) and, contrary to previous hypotheses, did not increase at puberty onset or in teenage years. Subjects with elevated TCDD levels and light hair colour had higher relative odds of chloracne (OR = 9.2, 95% CI 2.6-32.5). Conclusions: Dioxin toxicity in chloracne cases was confined to the acute dermatotoxic effects. Chloracne occurrence appeared related to younger age and light hair colour. Age-related dioxin elimination or dilution must be taken into account in interpreting these results.

UR - http://www.scopus.com/inward/record.url?scp=17444380788&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17444380788&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2133.2005.06444.x

DO - 10.1111/j.1365-2133.2005.06444.x

M3 - Article

C2 - 15787814

AN - SCOPUS:17444380788

VL - 152

SP - 459

EP - 465

JO - British Journal of Dermatology

JF - British Journal of Dermatology

SN - 0007-0963

IS - 3

ER -