Health status of Army Chemical Corps Vietnam veterans who sprayed defoliant in Vietnam

Han K. Kang, Nancy A. Dalager, Larry L. Needham, Donald G. Patterson, Peter S.J. Lees, Katherine Yates, Genevieve M. Matanoski

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Background: U.S. Army Chemical Corps veterans handled and sprayed herbicides in Vietnam resulting in exposure to Agent Orange and its contaminant 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin). This study examined the long-term health effects associated with herbicide exposure among these Vietnam veterans. Methods: A health survey of these 1,499 Vietnam veterans and a group of 1,428 non-Vietnam veterans assigned to chemical operations jobs was conducted using a computer-assisted telephone interview (CATI) system. Exposure to herbicides was assessed by analyzing serum specimens from a sample of 897 veterans for dioxin. Logistic regression analyses were used to estimate the risk of selected medical outcomes associated with herbicide exposure. Results: Odds ratios for diabetes, heart disease, hypertension, and chronic respiratory disease were elevated, but not significantly (P > 0.05) for those who served in Vietnam. However, they were significantly elevated among those Vietnam veterans who sprayed herbicides: diabetes, odds ratio (OR) = 1.50 (95% confidence interval [95%CI] = 1.15-1.95); heart disease, OR = 1.52 (1.18-1.94); hypertension, OR = 1.32 (1.08-1.61); and chronic respiratory condition, OR = 1.62 (1.28-2.05). Hepatitis was associated with Vietnam service, but not with herbicide application. Conclusions: Vietnam veterans who were occupationally exposed to herbicide experienced a higher risk of several chronic medical conditions relative to other non-Vietnam veterans. A potential selection bias is of concern. However, there were relatively high participation rates in both the Vietnam and non-Vietnam veteran groups, and the prevalence rates of some of these medical conditions among non-Vietnam veterans were comparable to general populations. Therefore, self-selection factors are considered unlikely to have biased the study results.

Original languageEnglish (US)
Pages (from-to)875-884
Number of pages10
JournalAmerican Journal of Industrial Medicine
Volume49
Issue number11
DOIs
StatePublished - Nov 2006

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Vietnam
Veterans
Health Status
Herbicides
Odds Ratio
Dioxins
Heart Diseases
Hypertension
Selection Bias
Health Surveys
Hepatitis
Chronic Disease
Logistic Models
Regression Analysis
Confidence Intervals
Interviews

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

Kang, H. K., Dalager, N. A., Needham, L. L., Patterson, D. G., Lees, P. S. J., Yates, K., & Matanoski, G. M. (2006). Health status of Army Chemical Corps Vietnam veterans who sprayed defoliant in Vietnam. American Journal of Industrial Medicine, 49(11), 875-884. https://doi.org/10.1002/ajim.20385
Kang, Han K. ; Dalager, Nancy A. ; Needham, Larry L. ; Patterson, Donald G. ; Lees, Peter S.J. ; Yates, Katherine ; Matanoski, Genevieve M. / Health status of Army Chemical Corps Vietnam veterans who sprayed defoliant in Vietnam. In: American Journal of Industrial Medicine. 2006 ; Vol. 49, No. 11. pp. 875-884.
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title = "Health status of Army Chemical Corps Vietnam veterans who sprayed defoliant in Vietnam",
abstract = "Background: U.S. Army Chemical Corps veterans handled and sprayed herbicides in Vietnam resulting in exposure to Agent Orange and its contaminant 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin). This study examined the long-term health effects associated with herbicide exposure among these Vietnam veterans. Methods: A health survey of these 1,499 Vietnam veterans and a group of 1,428 non-Vietnam veterans assigned to chemical operations jobs was conducted using a computer-assisted telephone interview (CATI) system. Exposure to herbicides was assessed by analyzing serum specimens from a sample of 897 veterans for dioxin. Logistic regression analyses were used to estimate the risk of selected medical outcomes associated with herbicide exposure. Results: Odds ratios for diabetes, heart disease, hypertension, and chronic respiratory disease were elevated, but not significantly (P > 0.05) for those who served in Vietnam. However, they were significantly elevated among those Vietnam veterans who sprayed herbicides: diabetes, odds ratio (OR) = 1.50 (95{\%} confidence interval [95{\%}CI] = 1.15-1.95); heart disease, OR = 1.52 (1.18-1.94); hypertension, OR = 1.32 (1.08-1.61); and chronic respiratory condition, OR = 1.62 (1.28-2.05). Hepatitis was associated with Vietnam service, but not with herbicide application. Conclusions: Vietnam veterans who were occupationally exposed to herbicide experienced a higher risk of several chronic medical conditions relative to other non-Vietnam veterans. A potential selection bias is of concern. However, there were relatively high participation rates in both the Vietnam and non-Vietnam veteran groups, and the prevalence rates of some of these medical conditions among non-Vietnam veterans were comparable to general populations. Therefore, self-selection factors are considered unlikely to have biased the study results.",
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Kang, HK, Dalager, NA, Needham, LL, Patterson, DG, Lees, PSJ, Yates, K & Matanoski, GM 2006, 'Health status of Army Chemical Corps Vietnam veterans who sprayed defoliant in Vietnam', American Journal of Industrial Medicine, vol. 49, no. 11, pp. 875-884. https://doi.org/10.1002/ajim.20385

Health status of Army Chemical Corps Vietnam veterans who sprayed defoliant in Vietnam. / Kang, Han K.; Dalager, Nancy A.; Needham, Larry L.; Patterson, Donald G.; Lees, Peter S.J.; Yates, Katherine; Matanoski, Genevieve M.

In: American Journal of Industrial Medicine, Vol. 49, No. 11, 11.2006, p. 875-884.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Health status of Army Chemical Corps Vietnam veterans who sprayed defoliant in Vietnam

AU - Kang, Han K.

AU - Dalager, Nancy A.

AU - Needham, Larry L.

AU - Patterson, Donald G.

AU - Lees, Peter S.J.

AU - Yates, Katherine

AU - Matanoski, Genevieve M.

PY - 2006/11

Y1 - 2006/11

N2 - Background: U.S. Army Chemical Corps veterans handled and sprayed herbicides in Vietnam resulting in exposure to Agent Orange and its contaminant 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin). This study examined the long-term health effects associated with herbicide exposure among these Vietnam veterans. Methods: A health survey of these 1,499 Vietnam veterans and a group of 1,428 non-Vietnam veterans assigned to chemical operations jobs was conducted using a computer-assisted telephone interview (CATI) system. Exposure to herbicides was assessed by analyzing serum specimens from a sample of 897 veterans for dioxin. Logistic regression analyses were used to estimate the risk of selected medical outcomes associated with herbicide exposure. Results: Odds ratios for diabetes, heart disease, hypertension, and chronic respiratory disease were elevated, but not significantly (P > 0.05) for those who served in Vietnam. However, they were significantly elevated among those Vietnam veterans who sprayed herbicides: diabetes, odds ratio (OR) = 1.50 (95% confidence interval [95%CI] = 1.15-1.95); heart disease, OR = 1.52 (1.18-1.94); hypertension, OR = 1.32 (1.08-1.61); and chronic respiratory condition, OR = 1.62 (1.28-2.05). Hepatitis was associated with Vietnam service, but not with herbicide application. Conclusions: Vietnam veterans who were occupationally exposed to herbicide experienced a higher risk of several chronic medical conditions relative to other non-Vietnam veterans. A potential selection bias is of concern. However, there were relatively high participation rates in both the Vietnam and non-Vietnam veteran groups, and the prevalence rates of some of these medical conditions among non-Vietnam veterans were comparable to general populations. Therefore, self-selection factors are considered unlikely to have biased the study results.

AB - Background: U.S. Army Chemical Corps veterans handled and sprayed herbicides in Vietnam resulting in exposure to Agent Orange and its contaminant 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin). This study examined the long-term health effects associated with herbicide exposure among these Vietnam veterans. Methods: A health survey of these 1,499 Vietnam veterans and a group of 1,428 non-Vietnam veterans assigned to chemical operations jobs was conducted using a computer-assisted telephone interview (CATI) system. Exposure to herbicides was assessed by analyzing serum specimens from a sample of 897 veterans for dioxin. Logistic regression analyses were used to estimate the risk of selected medical outcomes associated with herbicide exposure. Results: Odds ratios for diabetes, heart disease, hypertension, and chronic respiratory disease were elevated, but not significantly (P > 0.05) for those who served in Vietnam. However, they were significantly elevated among those Vietnam veterans who sprayed herbicides: diabetes, odds ratio (OR) = 1.50 (95% confidence interval [95%CI] = 1.15-1.95); heart disease, OR = 1.52 (1.18-1.94); hypertension, OR = 1.32 (1.08-1.61); and chronic respiratory condition, OR = 1.62 (1.28-2.05). Hepatitis was associated with Vietnam service, but not with herbicide application. Conclusions: Vietnam veterans who were occupationally exposed to herbicide experienced a higher risk of several chronic medical conditions relative to other non-Vietnam veterans. A potential selection bias is of concern. However, there were relatively high participation rates in both the Vietnam and non-Vietnam veteran groups, and the prevalence rates of some of these medical conditions among non-Vietnam veterans were comparable to general populations. Therefore, self-selection factors are considered unlikely to have biased the study results.

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