Rao-Bhatia et al. investigate the signaling mechanisms of cell behavior during mammalian villus morphogenesis. They demonstrate that Hh signaling in the intestinal mesenchyme directly activates planar cell polarity genes, thereby regulating the stromal cell clustering behavior required for epithelial remodeling in villus formation.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Biochemistry, Genetics and Molecular Biology(all)
- Developmental Biology
- Cell Biology