Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development

Abilasha Rao-Bhatia, Min Zhu, Wen Chi Yin, Sabrina Coquenlorge, Xiaoyun Zhang, Janghee Woo, Yu Sun, Charlotte H. Dean, Aimin Liu, Chi chung Hui, Ramesh A. Shivdasani, Helen McNeill, Sevan Hopyan, Tae Hee Kim

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Rao-Bhatia et al. investigate the signaling mechanisms of cell behavior during mammalian villus morphogenesis. They demonstrate that Hh signaling in the intestinal mesenchyme directly activates planar cell polarity genes, thereby regulating the stromal cell clustering behavior required for epithelial remodeling in villus formation.

Original languageEnglish (US)
Pages (from-to)647-658.e6
JournalDevelopmental Cell
Volume52
Issue number5
DOIs
StatePublished - Mar 9 2020

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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