Hematoma clearance as a therapeutic target in intracerebral hemorrhage: From macro to micro

D. Andrew Wilkinson, Richard F. Keep, Ya Hua, Guohua Xi

Research output: Contribution to journalComment/debatepeer-review

24 Scopus citations

Abstract

Despite the absence of an intervention shown to improve outcomes in intracerebral hemorrhage, preclinical work has led to a greater understanding of the pathologic pathways of brain injury. Methods targeting hematoma clearance through both macroscopic (surgical) and microscopic (endogenous phagocytosis) means are currently under investigation, with multiple clinical trials ongoing. Macroscopic methods for removal involve both catheter- and endoscope-based therapies to remove the hematoma through minimally invasive surgery. Microscopic methods targeting hematoma clearance involve augmenting endogenous clearance pathways for red blood cells and altering the balance between phagocytosis and red blood cell lysis with the release of potentially harmful constituents (e.g. hemoglobin and iron) into the extracellular space.

Original languageEnglish (US)
Pages (from-to)741-745
Number of pages5
JournalJournal of Cerebral Blood Flow and Metabolism
Volume38
Issue number4
DOIs
StatePublished - Apr 1 2018

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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