Hematopoietic Stem Cell Transplantation Activity in Pediatric Cancer between 2008 and 2014 in the United States: A Center for International Blood and Marrow Transplant Research Report

Pooja Khandelwal, Heather R. Millard, Elizabeth Thiel, Hisham Abdel-Azim, Allistair A. Abraham, Jeffery J. Auletta, Farid Boulad, Valerie I. Brown, Bruce M. Camitta, Ka Wah Chan, Sonali Chaudhury, Morton J. Cowan, Miguel Angel-Diaz, Shahinaz M. Gadalla, Robert Peter Gale, Gregory Hale, Kimberly A. Kasow, Amy K. Keating, Carrie L. Kitko, Margaret L. MacMillanRichard F. Olsson, Kristin M. Page, Adriana Seber, Angela R. Smith, Anne B. Warwick, Baldeep Wirk, Parinda A. Mehta

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

This Center for International Blood and Marrow Transplant Research report describes the use of hematopoietic stem cell transplantation (HSCT) in pediatric patients with cancer, 4408 undergoing allogeneic (allo) and3076 undergoing autologous (auto) HSCT in the United States between 2008 and 2014. In both settings, there was a greater proportion of boys (n = 4327; 57%), children < 10 years of age (n = 4412; 59%), whites (n = 5787; 77%), and children with a performance score ≥ 90% at HSCT (n = 6187; 83%). Leukemia was the most common indication for an allo-transplant (n = 4170; 94%), and among these, acute lymphoblastic leukemia in second complete remission (n = 829; 20%) and acute myeloid leukemia in first complete remission (n = 800; 19%) werethe most common. The most frequently used donor relation, stem cell sources, and HLA match were unrelated donor (n = 2933; 67%), bone marrow (n = 2378; 54%), and matched at 8/8 HLA antigens (n = 1098; 37%) respectively. Most allo-transplants used myeloablative conditioning (n = 4070; 92%) and calcineurin inhibitors and methotrexate (n = 2245; 51%) for acute graft-versus-host disease prophylaxis. Neuroblastoma was the most common primary neoplasm for an auto-transplant (n = 1338; 44%). Tandem auto-transplants for neuroblastoma declined after 2012 (40% in 2011, 25% in 2012, and 8% in 2014), whereas tandem auto-transplants increased for brain tumors (57% in 2008 and 77% in 2014). Allo-transplants from relatives other than HLA-identical siblings doubled between 2008 and 2014 (3% in 2008 and 6% in 2014). These trends will be monitored in future reports of transplant practices in the United States.

Original languageEnglish (US)
Pages (from-to)1342-1349
Number of pages8
JournalBiology of Blood and Marrow Transplantation
Volume23
Issue number8
DOIs
StatePublished - Aug 2017

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

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    Khandelwal, P., Millard, H. R., Thiel, E., Abdel-Azim, H., Abraham, A. A., Auletta, J. J., Boulad, F., Brown, V. I., Camitta, B. M., Chan, K. W., Chaudhury, S., Cowan, M. J., Angel-Diaz, M., Gadalla, S. M., Gale, R. P., Hale, G., Kasow, K. A., Keating, A. K., Kitko, C. L., ... Mehta, P. A. (2017). Hematopoietic Stem Cell Transplantation Activity in Pediatric Cancer between 2008 and 2014 in the United States: A Center for International Blood and Marrow Transplant Research Report. Biology of Blood and Marrow Transplantation, 23(8), 1342-1349. https://doi.org/10.1016/j.bbmt.2017.04.018