Hemodynamic effects of carvedilol infusion and the contribution of the sympathetic nervous system in rats with heart failure

Yuichi Abe; Kenichi Watanabe; Shinji Sato; Yusuke Nagai; Fadia A. Kamal; Mir I.I. Wahed; Juan Wen; Gurusamy Narasimman; Meilei Ma; Palaniyandi Suresh; Toshihiro Takahashi; Hitoshi Tachikawa; Takeshi Kashimura; Naohito Tanabe; Makoto Kodama; Yoshifusa Aizawa; Kenichi Yamaguchi; Makoto Miyazaki; Masao Kakemi

doi:10.1159/000080375

Hemodynamic effects of carvedilol infusion and the contribution of the sympathetic nervous system in rats with heart failure

Yuichi Abe, Kenichi Watanabe, Shinji Sato, Yusuke Nagai, Fadia A. Kamal, Mir I.I. Wahed, Juan Wen, Gurusamy Narasimman, Meilei Ma, Palaniyandi Suresh, Toshihiro Takahashi, Hitoshi Tachikawa, Takeshi Kashimura, Naohito Tanabe, Makoto Kodama, Yoshifusa Aizawa, Kenichi Yamaguchi, Makoto Miyazaki, Masao Kakemi

Department of Orthopaedics and Rehabilitation

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated the contribution of the sympathetic nervous system (SNS) in maintaining the blood pressure and in regulating the cardiac function during and after carvedilol administration in rats with heart failure (group F). Left ventricular end-diastolic pressure, percent functional shortening, and rates of intraventricular pressure rise were significantly changed by carvedilol infusion as compared with the basal values in group N (normal rats), but not in group F. The left ventricular end-diastolic pressure was elevated, corresponding to the enhancement of the plasma norepinephrine (NE) concentration caused by carvedilol infusion, in group N. The enhancement of the plasma NE concentration induced by carvedilol administration in group F was higher than that in group N. The value for the maximal hypertensive effect of NE intravenous infusion (E _max) was decreased, and the plasma NE concentration at half-maximal effect (EC₅₀) was increased in group F as compared with the values in group N. These results indicate that the SNS (presynaptic) activity is increased and that the SNS receptor sensitivity in the cardiovascular regulation system is decreased in heart failure.

Original language	English (US)
Pages (from-to)	213-219
Number of pages	7
Journal	Pharmacology
Volume	72
Issue number	4
DOIs	https://doi.org/10.1159/000080375
State	Published - 2004

All Science Journal Classification (ASJC) codes

Pharmacology

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10.1159/000080375

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Abe, Y., Watanabe, K., Sato, S., Nagai, Y., Kamal, F. A., Wahed, M. I. I., Wen, J., Narasimman, G., Ma, M., Suresh, P., Takahashi, T., Tachikawa, H., Kashimura, T., Tanabe, N., Kodama, M., Aizawa, Y., Yamaguchi, K., Miyazaki, M., & Kakemi, M. (2004). Hemodynamic effects of carvedilol infusion and the contribution of the sympathetic nervous system in rats with heart failure. Pharmacology, 72(4), 213-219. https://doi.org/10.1159/000080375

@article{e77efe5f9b4142d6a64a2b0cf85e9cee,

title = "Hemodynamic effects of carvedilol infusion and the contribution of the sympathetic nervous system in rats with heart failure",

abstract = "We investigated the contribution of the sympathetic nervous system (SNS) in maintaining the blood pressure and in regulating the cardiac function during and after carvedilol administration in rats with heart failure (group F). Left ventricular end-diastolic pressure, percent functional shortening, and rates of intraventricular pressure rise were significantly changed by carvedilol infusion as compared with the basal values in group N (normal rats), but not in group F. The left ventricular end-diastolic pressure was elevated, corresponding to the enhancement of the plasma norepinephrine (NE) concentration caused by carvedilol infusion, in group N. The enhancement of the plasma NE concentration induced by carvedilol administration in group F was higher than that in group N. The value for the maximal hypertensive effect of NE intravenous infusion (E max) was decreased, and the plasma NE concentration at half-maximal effect (EC50) was increased in group F as compared with the values in group N. These results indicate that the SNS (presynaptic) activity is increased and that the SNS receptor sensitivity in the cardiovascular regulation system is decreased in heart failure.",

author = "Yuichi Abe and Kenichi Watanabe and Shinji Sato and Yusuke Nagai and Kamal, {Fadia A.} and Wahed, {Mir I.I.} and Juan Wen and Gurusamy Narasimman and Meilei Ma and Palaniyandi Suresh and Toshihiro Takahashi and Hitoshi Tachikawa and Takeshi Kashimura and Naohito Tanabe and Makoto Kodama and Yoshifusa Aizawa and Kenichi Yamaguchi and Makoto Miyazaki and Masao Kakemi",

year = "2004",

doi = "10.1159/000080375",

language = "English (US)",

volume = "72",

pages = "213--219",

journal = "Pharmacology",

issn = "0031-7012",

publisher = "S. Karger AG",

number = "4",

}

Abe, Y, Watanabe, K, Sato, S, Nagai, Y, Kamal, FA, Wahed, MII, Wen, J, Narasimman, G, Ma, M, Suresh, P, Takahashi, T, Tachikawa, H, Kashimura, T, Tanabe, N, Kodama, M, Aizawa, Y, Yamaguchi, K, Miyazaki, M & Kakemi, M 2004, 'Hemodynamic effects of carvedilol infusion and the contribution of the sympathetic nervous system in rats with heart failure', Pharmacology, vol. 72, no. 4, pp. 213-219. https://doi.org/10.1159/000080375

TY - JOUR

T1 - Hemodynamic effects of carvedilol infusion and the contribution of the sympathetic nervous system in rats with heart failure

AU - Abe, Yuichi

AU - Watanabe, Kenichi

AU - Sato, Shinji

AU - Nagai, Yusuke

AU - Kamal, Fadia A.

AU - Wahed, Mir I.I.

AU - Wen, Juan

AU - Narasimman, Gurusamy

AU - Ma, Meilei

AU - Suresh, Palaniyandi

AU - Takahashi, Toshihiro

AU - Tachikawa, Hitoshi

AU - Kashimura, Takeshi

AU - Tanabe, Naohito

AU - Kodama, Makoto

AU - Aizawa, Yoshifusa

AU - Yamaguchi, Kenichi

AU - Miyazaki, Makoto

AU - Kakemi, Masao

PY - 2004

Y1 - 2004

N2 - We investigated the contribution of the sympathetic nervous system (SNS) in maintaining the blood pressure and in regulating the cardiac function during and after carvedilol administration in rats with heart failure (group F). Left ventricular end-diastolic pressure, percent functional shortening, and rates of intraventricular pressure rise were significantly changed by carvedilol infusion as compared with the basal values in group N (normal rats), but not in group F. The left ventricular end-diastolic pressure was elevated, corresponding to the enhancement of the plasma norepinephrine (NE) concentration caused by carvedilol infusion, in group N. The enhancement of the plasma NE concentration induced by carvedilol administration in group F was higher than that in group N. The value for the maximal hypertensive effect of NE intravenous infusion (E max) was decreased, and the plasma NE concentration at half-maximal effect (EC50) was increased in group F as compared with the values in group N. These results indicate that the SNS (presynaptic) activity is increased and that the SNS receptor sensitivity in the cardiovascular regulation system is decreased in heart failure.

AB - We investigated the contribution of the sympathetic nervous system (SNS) in maintaining the blood pressure and in regulating the cardiac function during and after carvedilol administration in rats with heart failure (group F). Left ventricular end-diastolic pressure, percent functional shortening, and rates of intraventricular pressure rise were significantly changed by carvedilol infusion as compared with the basal values in group N (normal rats), but not in group F. The left ventricular end-diastolic pressure was elevated, corresponding to the enhancement of the plasma norepinephrine (NE) concentration caused by carvedilol infusion, in group N. The enhancement of the plasma NE concentration induced by carvedilol administration in group F was higher than that in group N. The value for the maximal hypertensive effect of NE intravenous infusion (E max) was decreased, and the plasma NE concentration at half-maximal effect (EC50) was increased in group F as compared with the values in group N. These results indicate that the SNS (presynaptic) activity is increased and that the SNS receptor sensitivity in the cardiovascular regulation system is decreased in heart failure.

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U2 - 10.1159/000080375

DO - 10.1159/000080375

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C2 - 15539880

AN - SCOPUS:8344228607

SN - 0031-7012

VL - 72

SP - 213

EP - 219

JO - Pharmacology

JF - Pharmacology

IS - 4

ER -

Hemodynamic effects of carvedilol infusion and the contribution of the sympathetic nervous system in rats with heart failure

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