Hemodynamic effects of the antiarrhythmic drug pirmenol

Harry R. Phillips, Richard S. Stack, Dwight D. Davis, Kenneth G. Morris, Kerry L. Lee, David G. Shand, Edward L C Pritchett

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We examined the hemodynamic effects of pirmenol, a new antiarrhythmic drug, for the first time in man. Right and left heart pressures, Fick cardiac output, and radionuclide ejection fraction were measured before and during infusion of pirmenol in 10 patients with coronary artery disease who were undergoing routine diagnostic cardiac catheterization. Pirmenol was given as a 50-mg IV injection over 2 min followed by a constant infusion of 2.5 mg /min for up to 36 min. Plasma pirmenol levels were within or near the previously determined therapeutic range in all patients. There were no significant changes in systolic blood pressure or cardiac output. Diastolic blood pressure rose from a mean (±SD) 78 ± 7 during the control period to 82 ± 6 during the infusion, heart rate rose from 66 ± 6 during the control period to 75 ± 7 during infusion and ejection fraction fell from 60 ± 8 during control to 55 ± 12 during infusion. Although the left ventricular end-diastolic pressure rose from 6 ± 2 during control to 8 ± 3 during the infusion, the left ventricular stroke work index fell and the left ventricular work index per minute did not change. The fall in ejection fraction did not correlate with the control ejection fraction, plasma pirmenol levels, or the change in heart rate. The decline in ejection fraction and the failure of the left ventricular work index per minute to rise despite a small rise in left ventricular end-diastolic pressure may indicate a potential myocardial depressant effect of pirmenol.

Original languageEnglish (US)
Pages (from-to)235-239
Number of pages5
JournalClinical pharmacology and therapeutics
Volume32
Issue number2
DOIs
StatePublished - Jan 1 1982

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Anti-Arrhythmia Agents
Hemodynamics
Blood Pressure
Cardiac Output
Heart Rate
Cardiac Catheterization
Radioisotopes
pirmenol
Coronary Artery Disease
Stroke
Pressure
Injections

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

Phillips, H. R., Stack, R. S., Davis, D. D., Morris, K. G., Lee, K. L., Shand, D. G., & Pritchett, E. L. C. (1982). Hemodynamic effects of the antiarrhythmic drug pirmenol. Clinical pharmacology and therapeutics, 32(2), 235-239. https://doi.org/10.1038/clpt.1982.153
Phillips, Harry R. ; Stack, Richard S. ; Davis, Dwight D. ; Morris, Kenneth G. ; Lee, Kerry L. ; Shand, David G. ; Pritchett, Edward L C. / Hemodynamic effects of the antiarrhythmic drug pirmenol. In: Clinical pharmacology and therapeutics. 1982 ; Vol. 32, No. 2. pp. 235-239.
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abstract = "We examined the hemodynamic effects of pirmenol, a new antiarrhythmic drug, for the first time in man. Right and left heart pressures, Fick cardiac output, and radionuclide ejection fraction were measured before and during infusion of pirmenol in 10 patients with coronary artery disease who were undergoing routine diagnostic cardiac catheterization. Pirmenol was given as a 50-mg IV injection over 2 min followed by a constant infusion of 2.5 mg /min for up to 36 min. Plasma pirmenol levels were within or near the previously determined therapeutic range in all patients. There were no significant changes in systolic blood pressure or cardiac output. Diastolic blood pressure rose from a mean (±SD) 78 ± 7 during the control period to 82 ± 6 during the infusion, heart rate rose from 66 ± 6 during the control period to 75 ± 7 during infusion and ejection fraction fell from 60 ± 8 during control to 55 ± 12 during infusion. Although the left ventricular end-diastolic pressure rose from 6 ± 2 during control to 8 ± 3 during the infusion, the left ventricular stroke work index fell and the left ventricular work index per minute did not change. The fall in ejection fraction did not correlate with the control ejection fraction, plasma pirmenol levels, or the change in heart rate. The decline in ejection fraction and the failure of the left ventricular work index per minute to rise despite a small rise in left ventricular end-diastolic pressure may indicate a potential myocardial depressant effect of pirmenol.",
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Phillips, HR, Stack, RS, Davis, DD, Morris, KG, Lee, KL, Shand, DG & Pritchett, ELC 1982, 'Hemodynamic effects of the antiarrhythmic drug pirmenol', Clinical pharmacology and therapeutics, vol. 32, no. 2, pp. 235-239. https://doi.org/10.1038/clpt.1982.153

Hemodynamic effects of the antiarrhythmic drug pirmenol. / Phillips, Harry R.; Stack, Richard S.; Davis, Dwight D.; Morris, Kenneth G.; Lee, Kerry L.; Shand, David G.; Pritchett, Edward L C.

In: Clinical pharmacology and therapeutics, Vol. 32, No. 2, 01.01.1982, p. 235-239.

Research output: Contribution to journalArticle

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