Hemoglobin E protects against acute Plasmodium vivax infections in a Kachin population at the China–Myanmar border

Zeshuai Deng, Qing Li, Haoan Yi, Yanjie Zhang, Fang Yang, Hong Li, Lan Luo, Limei Ma, Zhaoqing Yang, Yongshu He, Liwang Cui

Research output: Contribution to journalArticle

Abstract

Objectives: Hemoglobin E (HbE, β 26 Glu-Lys ) is the most prevalent hemoglobinopathy in Southeast Asia. This study aimed to determine whether HbE protects against clinical Plasmodium vivax malaria in Southeast Asia. Methods: In a case-control study performed in villages along the China-Myanmar border, we determined the prevalence of HbE in 257 villagers who had acute P. vivax infections and in 157 control healthy villagers. Results: HbE in P. vivax patients (17.4%) was significantly less prevalent than in the healthy villager population (36.3%). Moreover, there was a complete lack of HbEE homozygotes in the vivax patients as compared to 9.5% prevalence in the healthy villagers. Using the HbAA group as the reference, both the HbEA heterozygotes and HbEE homozygotes had significantly lower odds of presenting with acute P. vivax infections. Furthermore, HbEA heterozygotes also had significantly lower P. vivax asexual parasite densities. HbEA did not affect the proportion of P. vivax patients with gametocytemia nor the gametocyte densities. Conclusions: HbE offers significant protection against the occurrence and parasite density of acute P. vivax infections and provides a renewed perspective on P. vivax malaria as a potentially strong driving force behind the high frequencies of HbE in the Kachin population.

Original languageEnglish (US)
Pages (from-to)435-439
Number of pages5
JournalJournal of Infection
Volume77
Issue number5
DOIs
StatePublished - Nov 1 2018

Fingerprint

Hemoglobin E
Plasmodium vivax
Malaria
Population
Vivax Malaria
Southeastern Asia
Homozygote
Heterozygote
Parasites
Myanmar
Hemoglobinopathies
Case-Control Studies
China

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Deng, Zeshuai ; Li, Qing ; Yi, Haoan ; Zhang, Yanjie ; Yang, Fang ; Li, Hong ; Luo, Lan ; Ma, Limei ; Yang, Zhaoqing ; He, Yongshu ; Cui, Liwang. / Hemoglobin E protects against acute Plasmodium vivax infections in a Kachin population at the China–Myanmar border. In: Journal of Infection. 2018 ; Vol. 77, No. 5. pp. 435-439.
@article{ecca9bd985794b0989e4948d67165aa8,
title = "Hemoglobin E protects against acute Plasmodium vivax infections in a Kachin population at the China–Myanmar border",
abstract = "Objectives: Hemoglobin E (HbE, β 26 Glu-Lys ) is the most prevalent hemoglobinopathy in Southeast Asia. This study aimed to determine whether HbE protects against clinical Plasmodium vivax malaria in Southeast Asia. Methods: In a case-control study performed in villages along the China-Myanmar border, we determined the prevalence of HbE in 257 villagers who had acute P. vivax infections and in 157 control healthy villagers. Results: HbE in P. vivax patients (17.4{\%}) was significantly less prevalent than in the healthy villager population (36.3{\%}). Moreover, there was a complete lack of HbEE homozygotes in the vivax patients as compared to 9.5{\%} prevalence in the healthy villagers. Using the HbAA group as the reference, both the HbEA heterozygotes and HbEE homozygotes had significantly lower odds of presenting with acute P. vivax infections. Furthermore, HbEA heterozygotes also had significantly lower P. vivax asexual parasite densities. HbEA did not affect the proportion of P. vivax patients with gametocytemia nor the gametocyte densities. Conclusions: HbE offers significant protection against the occurrence and parasite density of acute P. vivax infections and provides a renewed perspective on P. vivax malaria as a potentially strong driving force behind the high frequencies of HbE in the Kachin population.",
author = "Zeshuai Deng and Qing Li and Haoan Yi and Yanjie Zhang and Fang Yang and Hong Li and Lan Luo and Limei Ma and Zhaoqing Yang and Yongshu He and Liwang Cui",
year = "2018",
month = "11",
day = "1",
doi = "10.1016/j.jinf.2018.06.005",
language = "English (US)",
volume = "77",
pages = "435--439",
journal = "Journal of Infection",
issn = "0163-4453",
publisher = "W.B. Saunders Ltd",
number = "5",

}

Deng, Z, Li, Q, Yi, H, Zhang, Y, Yang, F, Li, H, Luo, L, Ma, L, Yang, Z, He, Y & Cui, L 2018, 'Hemoglobin E protects against acute Plasmodium vivax infections in a Kachin population at the China–Myanmar border', Journal of Infection, vol. 77, no. 5, pp. 435-439. https://doi.org/10.1016/j.jinf.2018.06.005

Hemoglobin E protects against acute Plasmodium vivax infections in a Kachin population at the China–Myanmar border. / Deng, Zeshuai; Li, Qing; Yi, Haoan; Zhang, Yanjie; Yang, Fang; Li, Hong; Luo, Lan; Ma, Limei; Yang, Zhaoqing; He, Yongshu; Cui, Liwang.

In: Journal of Infection, Vol. 77, No. 5, 01.11.2018, p. 435-439.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hemoglobin E protects against acute Plasmodium vivax infections in a Kachin population at the China–Myanmar border

AU - Deng, Zeshuai

AU - Li, Qing

AU - Yi, Haoan

AU - Zhang, Yanjie

AU - Yang, Fang

AU - Li, Hong

AU - Luo, Lan

AU - Ma, Limei

AU - Yang, Zhaoqing

AU - He, Yongshu

AU - Cui, Liwang

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Objectives: Hemoglobin E (HbE, β 26 Glu-Lys ) is the most prevalent hemoglobinopathy in Southeast Asia. This study aimed to determine whether HbE protects against clinical Plasmodium vivax malaria in Southeast Asia. Methods: In a case-control study performed in villages along the China-Myanmar border, we determined the prevalence of HbE in 257 villagers who had acute P. vivax infections and in 157 control healthy villagers. Results: HbE in P. vivax patients (17.4%) was significantly less prevalent than in the healthy villager population (36.3%). Moreover, there was a complete lack of HbEE homozygotes in the vivax patients as compared to 9.5% prevalence in the healthy villagers. Using the HbAA group as the reference, both the HbEA heterozygotes and HbEE homozygotes had significantly lower odds of presenting with acute P. vivax infections. Furthermore, HbEA heterozygotes also had significantly lower P. vivax asexual parasite densities. HbEA did not affect the proportion of P. vivax patients with gametocytemia nor the gametocyte densities. Conclusions: HbE offers significant protection against the occurrence and parasite density of acute P. vivax infections and provides a renewed perspective on P. vivax malaria as a potentially strong driving force behind the high frequencies of HbE in the Kachin population.

AB - Objectives: Hemoglobin E (HbE, β 26 Glu-Lys ) is the most prevalent hemoglobinopathy in Southeast Asia. This study aimed to determine whether HbE protects against clinical Plasmodium vivax malaria in Southeast Asia. Methods: In a case-control study performed in villages along the China-Myanmar border, we determined the prevalence of HbE in 257 villagers who had acute P. vivax infections and in 157 control healthy villagers. Results: HbE in P. vivax patients (17.4%) was significantly less prevalent than in the healthy villager population (36.3%). Moreover, there was a complete lack of HbEE homozygotes in the vivax patients as compared to 9.5% prevalence in the healthy villagers. Using the HbAA group as the reference, both the HbEA heterozygotes and HbEE homozygotes had significantly lower odds of presenting with acute P. vivax infections. Furthermore, HbEA heterozygotes also had significantly lower P. vivax asexual parasite densities. HbEA did not affect the proportion of P. vivax patients with gametocytemia nor the gametocyte densities. Conclusions: HbE offers significant protection against the occurrence and parasite density of acute P. vivax infections and provides a renewed perspective on P. vivax malaria as a potentially strong driving force behind the high frequencies of HbE in the Kachin population.

UR - http://www.scopus.com/inward/record.url?scp=85049570731&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049570731&partnerID=8YFLogxK

U2 - 10.1016/j.jinf.2018.06.005

DO - 10.1016/j.jinf.2018.06.005

M3 - Article

C2 - 29964138

AN - SCOPUS:85049570731

VL - 77

SP - 435

EP - 439

JO - Journal of Infection

JF - Journal of Infection

SN - 0163-4453

IS - 5

ER -