Hemolytic-uremic syndrome in a postpartum mare concurrent with encephalopathy in the neonatal foal

Charles E. Dickinson, Daniel H. Gould, Ann H. Davidson, Paul R. Avery, Marie E. Legare, Doreene R. Hyatt, Chitrita Debroy

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A postpartum mare and foal were presented for evaluation of fever and lethargy in the mare. The mare was diagnosed with endometritis and initially responded well to treatment. On the second day of hospitalization, the mare developed renal insufficiency characterized by oliguria, azotemia, hemolysis, and thrombocytopenia. Concurrently, the foal developed rapidly progressive central nervous system signs culminating in refractory seizures. Both animals failed to respond to treatment and were euthanized. Thrombotic microangiopathy involving glomeruli was evident on microscopic examination of the mare's kidneys. Microscopic evidence of brain edema was the principal postmortem finding in the foal. No specific etiology was confirmed in either case. Notably, Escherichia coli 0103:H2 was isolated from the mare's uterus and the gastrointestinal tracts of both animals. To the authors' knowledge, this is the first report in which an organism implicated as a cause of hemolytic-uremic syndrome was isolated from an animal with clinical signs and postmortem findings consistent with the disease.

Original languageEnglish (US)
Pages (from-to)239-242
Number of pages4
JournalJournal of Veterinary Diagnostic Investigation
Volume20
Issue number2
DOIs
StatePublished - Mar 1 2008

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hemolytic uremic syndrome
Hemolytic-Uremic Syndrome
encephalopathy
Brain Diseases
foals
Postpartum Period
mares
Thrombotic Microangiopathies
Azotemia
Oliguria
Endometritis
Lethargy
Brain Edema
Hemolysis
Thrombocytopenia
Uterus
Renal Insufficiency
Gastrointestinal Tract
Seizures
Hospitalization

All Science Journal Classification (ASJC) codes

  • veterinary(all)

Cite this

Dickinson, C. E., Gould, D. H., Davidson, A. H., Avery, P. R., Legare, M. E., Hyatt, D. R., & Debroy, C. (2008). Hemolytic-uremic syndrome in a postpartum mare concurrent with encephalopathy in the neonatal foal. Journal of Veterinary Diagnostic Investigation, 20(2), 239-242. https://doi.org/10.1177/104063870802000218
Dickinson, Charles E. ; Gould, Daniel H. ; Davidson, Ann H. ; Avery, Paul R. ; Legare, Marie E. ; Hyatt, Doreene R. ; Debroy, Chitrita. / Hemolytic-uremic syndrome in a postpartum mare concurrent with encephalopathy in the neonatal foal. In: Journal of Veterinary Diagnostic Investigation. 2008 ; Vol. 20, No. 2. pp. 239-242.
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Dickinson, CE, Gould, DH, Davidson, AH, Avery, PR, Legare, ME, Hyatt, DR & Debroy, C 2008, 'Hemolytic-uremic syndrome in a postpartum mare concurrent with encephalopathy in the neonatal foal', Journal of Veterinary Diagnostic Investigation, vol. 20, no. 2, pp. 239-242. https://doi.org/10.1177/104063870802000218

Hemolytic-uremic syndrome in a postpartum mare concurrent with encephalopathy in the neonatal foal. / Dickinson, Charles E.; Gould, Daniel H.; Davidson, Ann H.; Avery, Paul R.; Legare, Marie E.; Hyatt, Doreene R.; Debroy, Chitrita.

In: Journal of Veterinary Diagnostic Investigation, Vol. 20, No. 2, 01.03.2008, p. 239-242.

Research output: Contribution to journalArticle

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