Hemostatic imbalances produced by plasma exchange

Ronald Domen, MS Kennedy, LL Jones, DA Senhauser

Research output: Contribution to journalArticle

28 Scopus citations


Ten patients who underwent intensive therapeutic plasma exchange were studied prospectively to determine the nature and extent of changes induced in their coagulation mechanisms. The patients' plasma was replaced with serum albumin and normal saline. Significant changes were noted acutely in the prothrombin time, activated partial thromboplastin time, plasma fibrinogen, and platelet counts. Chronically, significant decreases were found in plasma fibrinogen concentrations and platelet counts. Intensive plasma exchange with fluids devoid of coagulation factors results in defects in the normal hemostatic mechanism.

Original languageEnglish (US)
Pages (from-to)336-339
Number of pages4
Issue number4
Publication statusPublished - Jan 1 1984


All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Hematology

Cite this