Hepatitis b virus, hepatitis a virus and persistently elevated aminotransferases in hemophiliacs

R. J. Gerety, M. E. Eyster, E. Tabor, J. A. Drucker, C. J. Lusch, D. Prager, S. A.,. Rice And, H. S. Bowman

    Research output: Contribution to journalArticlepeer-review

    22 Scopus citations

    Abstract

    To determine the exposure to hepatitis A and hepatitis B viruses (HAV, HBV) following intravenous replacement therapy in patients with classic hemophilia and to assess the role of these viruses in persistently elevated aminotransferases, sera were studied from 136 patients from 9 months to 67 years of age who were transfused with either single‐donor cryoprecipitate (CRYO) or Antihemophilic Factor Concentrate (AHF) for periods ranging from a few months to 15 years. Serologic evidence of past or present infection with HBV was detected in 90% of all 136 patients and in 85% of those 34 patients 10 years of age or younger. Sixty‐four percent of those with serologic markers of hepatitis B had high liters of antibody to the hepatitis B surface antigen and low titers of antibody to the hepatitis B core antigen. These findings are consistent with the known high frequency of early exposure to HBV in hemophiliacs receiving replacement therapy and with recovery from these hepatitis B infections. Sixteen percent of these patients had persistently elevated aminotransferase levels; HBV could not be implicated as the cause of the enzyme elevations in most of these cases.

    Original languageEnglish (US)
    Pages (from-to)111-118
    Number of pages8
    JournalJournal of Medical Virology
    Volume6
    Issue number2
    DOIs
    StatePublished - 1980

    All Science Journal Classification (ASJC) codes

    • Virology
    • Infectious Diseases

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