Hepatitis C virus non-structural protein 3 (HCV NS3): A multifunctional antiviral target

Kevin D. Raney, Suresh D. Sharma, Ibrahim M. Moustafa, Craig E. Cameron

Research output: Contribution to journalShort surveypeer-review

124 Scopus citations

Abstract

Hepatitis C virus non-structural protein 3 contains a serine protease and an RNA helicase. Protease cleaves the genomeencoded polyprotein and inactivates cellular proteins required for innate immunity. Protease has emerged as an important target for the development of antiviral therapeutics, but drug resistance has turned out to be an obstacle in the clinic. Helicase is required for both genome replication and virus assembly. Mechanistic and structural studies of helicase have hurled this enzyme into a prominent position in the field of helicase enzymology. Nevertheless, studies of helicase as an antiviral target remain in their infancy.

Original languageEnglish (US)
Pages (from-to)22725-22731
Number of pages7
JournalJournal of Biological Chemistry
Volume285
Issue number30
DOIs
StatePublished - Jul 23 2010

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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