Hepatitis E in southern Vietnam: Seroepidemiology in humans and molecular epidemiology in pigs

The VIZIONS Consortium

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Viral pathogens account for a significant proportion of the burden of emerging infectious diseases in humans. The Wellcome Trust-Vietnamese Initiative on Zoonotic Infections (WT-VIZIONS) is aiming to understand the circulation of viral zoonotic pathogens in animals that pose a potential risk to human health. Evidence suggests that human exposure and infections with hepatitis E virus (HEV) genotypes (GT) 3 and 4 results from zoonotic transmission. Hypothesising that HEV GT3 and GT4 are circulating in the Vietnamese pig population and can be transmitted to humans, we aimed to estimate the seroprevalence of HEV exposure in a population of farmers and the general population. We additionally performed sequence analysis of HEV in pig populations in the same region to address knowledge gaps regarding HEV circulation and to evaluate if pigs were a potential source of HEV exposure. We found a high prevalence of HEV GT3 viral RNA in pigs (19.1% in faecal samples and 8.2% in rectal swabs) and a high HEV seroprevalence in pig farmers (16.0%) and a hospital-attending population (31.7%) in southern Vietnam. The hospital population was recruited as a general-population proxy even though this particular population subgroup may introduce bias. The detection of HEV RNA in pigs indicates that HEV may be a zoonotic disease risk in this location, although a larger sample size is required to infer an association between HEV positivity in pigs and seroprevalence in humans.

Original languageEnglish (US)
Pages (from-to)43-50
Number of pages8
JournalZoonoses and Public Health
Volume65
Issue number1
DOIs
StatePublished - Feb 1 2018

Fingerprint

hepatitis E
Hepatitis E
Hepatitis E virus
molecular epidemiology
Molecular Epidemiology
Vietnam
serological surveys
Swine
swine
Zoonoses
Population
Seroepidemiologic Studies
seroprevalence
RNA
Emerging Communicable Diseases
farmers
animal pathogens
emerging diseases
Viral RNA
Proxy

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

@article{3e7f1f7af5b04b40921cb277bb8f5c91,
title = "Hepatitis E in southern Vietnam: Seroepidemiology in humans and molecular epidemiology in pigs",
abstract = "Viral pathogens account for a significant proportion of the burden of emerging infectious diseases in humans. The Wellcome Trust-Vietnamese Initiative on Zoonotic Infections (WT-VIZIONS) is aiming to understand the circulation of viral zoonotic pathogens in animals that pose a potential risk to human health. Evidence suggests that human exposure and infections with hepatitis E virus (HEV) genotypes (GT) 3 and 4 results from zoonotic transmission. Hypothesising that HEV GT3 and GT4 are circulating in the Vietnamese pig population and can be transmitted to humans, we aimed to estimate the seroprevalence of HEV exposure in a population of farmers and the general population. We additionally performed sequence analysis of HEV in pig populations in the same region to address knowledge gaps regarding HEV circulation and to evaluate if pigs were a potential source of HEV exposure. We found a high prevalence of HEV GT3 viral RNA in pigs (19.1{\%} in faecal samples and 8.2{\%} in rectal swabs) and a high HEV seroprevalence in pig farmers (16.0{\%}) and a hospital-attending population (31.7{\%}) in southern Vietnam. The hospital population was recruited as a general-population proxy even though this particular population subgroup may introduce bias. The detection of HEV RNA in pigs indicates that HEV may be a zoonotic disease risk in this location, although a larger sample size is required to infer an association between HEV positivity in pigs and seroprevalence in humans.",
author = "{The VIZIONS Consortium} and A. Berto and Pham, {H. A.} and Thao, {T. T.N.} and Vy, {N. H.T.} and Caddy, {S. L.} and R. Hiraide and Tue, {N. T.} and I. Goodfellow and Carrique-Mas, {J. J.} and Thwaites, {G. E.} and S. Baker and Boni, {M. F.} and Kiet, {Bach Tuan} and Bryant, {Juliet E.} and Phu, {Bui Duc} and Campbell, {James I.} and Hung, {Dang Manh} and Huong, {Dang Thao} and Oanh, {Dang Tram} and Day, {Jeremy N.} and {Van Tan}, Dinh and {van Doorn}, {H. Rogier} and Han, {Duong An} and Farrar, {Jeremy J.} and Trang, {Hau Thi Thu} and Nghia, {Ho Dang Trung} and Long, {Hoang Bao} and {Van Duong}, Hoang and Thu, {Huynh Thi Kim} and Cuong, {Lam Chi} and Manh Hung and Thanh Phuong and Thi Phuc and Thi Phuong and Xuan Luat and Ha, {Luu Thi Thu} and {Van Chuong}, Ly and Loan, {Mai Thi Phuoc} and Behzad Nadjm and Bao, {Ngo Thanh} and Hoa, {Ngo Thi} and Tu, {Nguyen Canh} and Thuan, {Nguyen Dac} and Nguyen Dong and Chuyen, {Nguyen Khac} and An, {Nguyen Ngoc} and Vinh, {Nguyen Ngoc} and Hung, {Nguyen Quoc} and Dung, {Nguyen Thanh} and Minh, {Nguyen Thanh}",
year = "2018",
month = "2",
day = "1",
doi = "10.1111/zph.12364",
language = "English (US)",
volume = "65",
pages = "43--50",
journal = "Zoonoses and Public Health",
issn = "1863-1959",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "1",

}

Hepatitis E in southern Vietnam : Seroepidemiology in humans and molecular epidemiology in pigs. / The VIZIONS Consortium.

In: Zoonoses and Public Health, Vol. 65, No. 1, 01.02.2018, p. 43-50.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hepatitis E in southern Vietnam

T2 - Seroepidemiology in humans and molecular epidemiology in pigs

AU - The VIZIONS Consortium

AU - Berto, A.

AU - Pham, H. A.

AU - Thao, T. T.N.

AU - Vy, N. H.T.

AU - Caddy, S. L.

AU - Hiraide, R.

AU - Tue, N. T.

AU - Goodfellow, I.

AU - Carrique-Mas, J. J.

AU - Thwaites, G. E.

AU - Baker, S.

AU - Boni, M. F.

AU - Kiet, Bach Tuan

AU - Bryant, Juliet E.

AU - Phu, Bui Duc

AU - Campbell, James I.

AU - Hung, Dang Manh

AU - Huong, Dang Thao

AU - Oanh, Dang Tram

AU - Day, Jeremy N.

AU - Van Tan, Dinh

AU - van Doorn, H. Rogier

AU - Han, Duong An

AU - Farrar, Jeremy J.

AU - Trang, Hau Thi Thu

AU - Nghia, Ho Dang Trung

AU - Long, Hoang Bao

AU - Van Duong, Hoang

AU - Thu, Huynh Thi Kim

AU - Cuong, Lam Chi

AU - Hung, Manh

AU - Phuong, Thanh

AU - Phuc, Thi

AU - Phuong, Thi

AU - Luat, Xuan

AU - Ha, Luu Thi Thu

AU - Van Chuong, Ly

AU - Loan, Mai Thi Phuoc

AU - Nadjm, Behzad

AU - Bao, Ngo Thanh

AU - Hoa, Ngo Thi

AU - Tu, Nguyen Canh

AU - Thuan, Nguyen Dac

AU - Dong, Nguyen

AU - Chuyen, Nguyen Khac

AU - An, Nguyen Ngoc

AU - Vinh, Nguyen Ngoc

AU - Hung, Nguyen Quoc

AU - Dung, Nguyen Thanh

AU - Minh, Nguyen Thanh

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Viral pathogens account for a significant proportion of the burden of emerging infectious diseases in humans. The Wellcome Trust-Vietnamese Initiative on Zoonotic Infections (WT-VIZIONS) is aiming to understand the circulation of viral zoonotic pathogens in animals that pose a potential risk to human health. Evidence suggests that human exposure and infections with hepatitis E virus (HEV) genotypes (GT) 3 and 4 results from zoonotic transmission. Hypothesising that HEV GT3 and GT4 are circulating in the Vietnamese pig population and can be transmitted to humans, we aimed to estimate the seroprevalence of HEV exposure in a population of farmers and the general population. We additionally performed sequence analysis of HEV in pig populations in the same region to address knowledge gaps regarding HEV circulation and to evaluate if pigs were a potential source of HEV exposure. We found a high prevalence of HEV GT3 viral RNA in pigs (19.1% in faecal samples and 8.2% in rectal swabs) and a high HEV seroprevalence in pig farmers (16.0%) and a hospital-attending population (31.7%) in southern Vietnam. The hospital population was recruited as a general-population proxy even though this particular population subgroup may introduce bias. The detection of HEV RNA in pigs indicates that HEV may be a zoonotic disease risk in this location, although a larger sample size is required to infer an association between HEV positivity in pigs and seroprevalence in humans.

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