Hereditary multiple exostoses: Report of a kindred

S. L. Gordon, J. R. Buchanan, R. L. Ladda

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

In a large family with 37 members with multiple exostoses, only one person has developed sarcomatous degeneration of a lesion. Our review of published reports revealed great variation in the incidence of malignancy in multiple exostoses (10 to 25%). Most studies had sampling errors leading to the apparent overstatement of risk. In large pedigrees with essentially complete ascertainment of affected subjects, the risk of malignancy is nearer 3% or less. This lower risk for malignancy may be more appropriate in counselling affected subjects.

Original languageEnglish (US)
Pages (from-to)428-430
Number of pages3
JournalJournal of medical genetics
Volume18
Issue number6
StatePublished - Dec 1 1981

Fingerprint

Multiple Hereditary Exostoses
Neoplasms
Selection Bias
Pedigree
Counseling
Incidence

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Gordon, S. L., Buchanan, J. R., & Ladda, R. L. (1981). Hereditary multiple exostoses: Report of a kindred. Journal of medical genetics, 18(6), 428-430.
Gordon, S. L. ; Buchanan, J. R. ; Ladda, R. L. / Hereditary multiple exostoses : Report of a kindred. In: Journal of medical genetics. 1981 ; Vol. 18, No. 6. pp. 428-430.
@article{c62beeca92e44cd78c9d2e638767d255,
title = "Hereditary multiple exostoses: Report of a kindred",
abstract = "In a large family with 37 members with multiple exostoses, only one person has developed sarcomatous degeneration of a lesion. Our review of published reports revealed great variation in the incidence of malignancy in multiple exostoses (10 to 25{\%}). Most studies had sampling errors leading to the apparent overstatement of risk. In large pedigrees with essentially complete ascertainment of affected subjects, the risk of malignancy is nearer 3{\%} or less. This lower risk for malignancy may be more appropriate in counselling affected subjects.",
author = "Gordon, {S. L.} and Buchanan, {J. R.} and Ladda, {R. L.}",
year = "1981",
month = "12",
day = "1",
language = "English (US)",
volume = "18",
pages = "428--430",
journal = "Journal of Medical Genetics",
issn = "0022-2593",
publisher = "BMJ Publishing Group",
number = "6",

}

Gordon, SL, Buchanan, JR & Ladda, RL 1981, 'Hereditary multiple exostoses: Report of a kindred', Journal of medical genetics, vol. 18, no. 6, pp. 428-430.

Hereditary multiple exostoses : Report of a kindred. / Gordon, S. L.; Buchanan, J. R.; Ladda, R. L.

In: Journal of medical genetics, Vol. 18, No. 6, 01.12.1981, p. 428-430.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hereditary multiple exostoses

T2 - Report of a kindred

AU - Gordon, S. L.

AU - Buchanan, J. R.

AU - Ladda, R. L.

PY - 1981/12/1

Y1 - 1981/12/1

N2 - In a large family with 37 members with multiple exostoses, only one person has developed sarcomatous degeneration of a lesion. Our review of published reports revealed great variation in the incidence of malignancy in multiple exostoses (10 to 25%). Most studies had sampling errors leading to the apparent overstatement of risk. In large pedigrees with essentially complete ascertainment of affected subjects, the risk of malignancy is nearer 3% or less. This lower risk for malignancy may be more appropriate in counselling affected subjects.

AB - In a large family with 37 members with multiple exostoses, only one person has developed sarcomatous degeneration of a lesion. Our review of published reports revealed great variation in the incidence of malignancy in multiple exostoses (10 to 25%). Most studies had sampling errors leading to the apparent overstatement of risk. In large pedigrees with essentially complete ascertainment of affected subjects, the risk of malignancy is nearer 3% or less. This lower risk for malignancy may be more appropriate in counselling affected subjects.

UR - http://www.scopus.com/inward/record.url?scp=0019793175&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019793175&partnerID=8YFLogxK

M3 - Article

C2 - 6977644

AN - SCOPUS:0019793175

VL - 18

SP - 428

EP - 430

JO - Journal of Medical Genetics

JF - Journal of Medical Genetics

SN - 0022-2593

IS - 6

ER -

Gordon SL, Buchanan JR, Ladda RL. Hereditary multiple exostoses: Report of a kindred. Journal of medical genetics. 1981 Dec 1;18(6):428-430.