Hereditary multiple exostoses: Report of a kindred

S. L. Gordon, J. R. Buchanan, R. L. Ladda

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

In a large family with 37 members with multiple exostoses, only one person has developed sarcomatous degeneration of a lesion. Our review of published reports revealed great variation in the incidence of malignancy in multiple exostoses (10 to 25%). Most studies had sampling errors leading to the apparent overstatement of risk. In large pedigrees with essentially complete ascertainment of affected subjects, the risk of malignancy is nearer 3% or less. This lower risk for malignancy may be more appropriate in counselling affected subjects.

Original languageEnglish (US)
Pages (from-to)428-430
Number of pages3
JournalJournal of medical genetics
Volume18
Issue number6
DOIs
StatePublished - 1981

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

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