Heterocyclic compounds. VI. Synthesis of poly nuclear thienopyrimidine derivatives

M. S. Manhas; Shantu Amin

doi:10.1002/jhet.5570130444

Heterocyclic compounds. VI. Synthesis of poly nuclear thienopyrimidine derivatives

M. S. Manhas, Shantu Amin

Research output: Contribution to journal › Comment/debate › peer-review

12 Scopus citations

Abstract

Quinazoline derivatives have received great interest because of their potential biological activity. This communication describes a facile method for the synthesis of substituted thiophenopyrimidones. 2‐Amino‐3‐earbethoxy‐4,5‐tetramethylenethiophene on heating with substituted imidoyl‐chlorides, iminoethers, iminothioethers or thioamides affords thiophenopyrimidones. By using this method a number of such compounds of varying complexity were synthesized which are otherwise not so easily accessible.

Original language	English (US)
Pages (from-to)	903-906
Number of pages	4
Journal	Journal of Heterocyclic Chemistry
Volume	13
Issue number	4
DOIs	https://doi.org/10.1002/jhet.5570130444
State	Published - Jan 1 1976

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Organic Chemistry

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abstract = "Quinazoline derivatives have received great interest because of their potential biological activity. This communication describes a facile method for the synthesis of substituted thiophenopyrimidones. 2‐Amino‐3‐earbethoxy‐4,5‐tetramethylenethiophene on heating with substituted imidoyl‐chlorides, iminoethers, iminothioethers or thioamides affords thiophenopyrimidones. By using this method a number of such compounds of varying complexity were synthesized which are otherwise not so easily accessible.",

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N2 - Quinazoline derivatives have received great interest because of their potential biological activity. This communication describes a facile method for the synthesis of substituted thiophenopyrimidones. 2‐Amino‐3‐earbethoxy‐4,5‐tetramethylenethiophene on heating with substituted imidoyl‐chlorides, iminoethers, iminothioethers or thioamides affords thiophenopyrimidones. By using this method a number of such compounds of varying complexity were synthesized which are otherwise not so easily accessible.

AB - Quinazoline derivatives have received great interest because of their potential biological activity. This communication describes a facile method for the synthesis of substituted thiophenopyrimidones. 2‐Amino‐3‐earbethoxy‐4,5‐tetramethylenethiophene on heating with substituted imidoyl‐chlorides, iminoethers, iminothioethers or thioamides affords thiophenopyrimidones. By using this method a number of such compounds of varying complexity were synthesized which are otherwise not so easily accessible.

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Heterocyclic compounds. VI. Synthesis of poly nuclear thienopyrimidine derivatives

Abstract

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