Heterocyclic compounds. VII. Synthesis of thiadiazasteroid analogs

M. S. Manhas, V. V. Rao, Shantu Amin

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The synthesis of a number of β‐northiadiaza steroid analogs has been described. Suitable o‐aminonitriles were acylated with γ‐chlorobutyryl chloride. These amidonitriles were cyclized to substituted γ‐lactams and subsequently to the tetracyclic products. To functionalize the “17‐position” in these steroids, the intermediate γ‐lactams were converted to arylidene derivatives before cyclization to the tetracyclic derivatives.

Original languageEnglish (US)
Pages (from-to)821-824
Number of pages4
JournalJournal of Heterocyclic Chemistry
Volume13
Issue number4
DOIs
StatePublished - Jan 1 1976

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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