Heterogeneous tissue scaffolds for spatiotemporally controlled release kinetics

Ibrahim Tarik Ozbolat, A. K.M.B. Khoda, M. Marchany, J. A. Gardella, B. Koc

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this research, hybrid tissue scaffolds are modeled, designed and fabricated to control release kinetics spatially and temporally for improved tissue regeneration. Heterogeneous porous tissue scaffolds with varying characteristics to mediate the release of base material and enclosed biological modifiers are proposed based on tissue engineering requirements. Firstly, a computer-aided biodegradation model is developed to simulate degradation process of micro-patterned polymeric membranes. Next, scaffolds are bio-mimetically designed to control internal porous architecture with varying porosity. A new optimized internal architecture scheme is developed to enhance fluid transport with continuous base material deposition plan. A sample scaffold encapsulated with microspheres is fabricated to explore the natural distribution of microspheres and a stochastic distribution model of biological modifiers is adapted from the image based microsphere distribution model. This study is extended for the development of hybrid scaffolds for spatial control of microspheres and base material to synchronize the release kinetics with tissue regeneration. Finally, a pressure-assisted multi-chamber single nozzle solid freeform fabrication (SFF) technique is utilized to fabricate hybrid scaffolds.

Original languageEnglish (US)
Title of host publicationInnovative Developments in Virtual and Physical Prototyping - Proceedings of the 5th International Conference on Advanced Research and Rapid Prototyping
Pages79-84
Number of pages6
StatePublished - Feb 13 2012
Event5th International Conference on Advanced Research in Virtual and Physical Prototyping, VR@P 2011 - Leiria, Portugal
Duration: Sep 28 2011Oct 1 2011

Publication series

NameInnovative Developments in Virtual and Physical Prototyping - Proceedings of the 5th International Conference on Advanced Research and Rapid Prototyping

Other

Other5th International Conference on Advanced Research in Virtual and Physical Prototyping, VR@P 2011
CountryPortugal
CityLeiria
Period9/28/1110/1/11

All Science Journal Classification (ASJC) codes

  • Artificial Intelligence
  • Computer Science Applications
  • Software

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  • Cite this

    Ozbolat, I. T., Khoda, A. K. M. B., Marchany, M., Gardella, J. A., & Koc, B. (2012). Heterogeneous tissue scaffolds for spatiotemporally controlled release kinetics. In Innovative Developments in Virtual and Physical Prototyping - Proceedings of the 5th International Conference on Advanced Research and Rapid Prototyping (pp. 79-84). (Innovative Developments in Virtual and Physical Prototyping - Proceedings of the 5th International Conference on Advanced Research and Rapid Prototyping).