Heterogeneous vasodilator responses of human limbs

Influence of age and habitual endurance training

Scan C. Newcomer, Urs Leuenberger, Cynthia S. Hogeman, David Nathan Proctor

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Forearm endothelium-dependent vasodilation is impaired with age in sedentary, but not endurance-trained, men. The purpose of this investigation was to determine whether these age- and physical activity-related differences in endothelium-dependent vasodilation also occur in the leg. Brachial and common femoral arterial blood flow were measured with Doppler ultrasound during increasing doses of acetylcholine (1, 4, and 16 1 μg · 100 ml limb tissue-1 · min-1), substance P (8, 31, and 125 pg·100 ml limb tissue-1· min-1), and sodium nitroprusside (0.063, 0.25, and 1 μg · 100 ml limb tissue-1 · min-1) in 23 healthy men (8 younger sedentary, 8 older sedentary, and 7 older endurance trained). Increases in forearm blood flow to the highest dose of acetylcholine and sodium nitroprusside were smaller (P < 0.05) in older sedentary (841 ± 142%, 428 ± 74%) compared with younger sedentary (1,519 ± 256%, 925 ± 163%) subjects. Similarly, increases in forearm blood flow to sodium nitroprusside (1 μg · 100 ml limb tissue-1 · min-1) were smaller (P < 0.05) in older endurance-trained (505 ± 110%) compared with younger sedentary (925 ± 163%) subjects. In contrast, no differences in leg blood flow responses to intra-arterial infusions of acetylcholine, substance P, or sodium nitroprusside were noted between subject groups. These results demonstrate that 1) acetylcholine-and sodium nitroprusside-induced vasodilation are attenuated in the forearm vasculature and preserved in the leg vasculature of older sedentary subjects and 2) sodium nitroprusside-induced vasodilation remains attenuated in the forearm vasculature of healthy older endurance-trained men but preserved in the leg vasculature of these men.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume289
Issue number1 58-1
DOIs
StatePublished - Jul 1 2005

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Nitroprusside
Vasodilator Agents
Forearm
Extremities
Vasodilation
Acetylcholine
Leg
Substance P
Endothelium
Doppler Ultrasonography
Intra Arterial Infusions
Thigh
Arm
Exercise

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

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title = "Heterogeneous vasodilator responses of human limbs: Influence of age and habitual endurance training",
abstract = "Forearm endothelium-dependent vasodilation is impaired with age in sedentary, but not endurance-trained, men. The purpose of this investigation was to determine whether these age- and physical activity-related differences in endothelium-dependent vasodilation also occur in the leg. Brachial and common femoral arterial blood flow were measured with Doppler ultrasound during increasing doses of acetylcholine (1, 4, and 16 1 μg · 100 ml limb tissue-1 · min-1), substance P (8, 31, and 125 pg·100 ml limb tissue-1· min-1), and sodium nitroprusside (0.063, 0.25, and 1 μg · 100 ml limb tissue-1 · min-1) in 23 healthy men (8 younger sedentary, 8 older sedentary, and 7 older endurance trained). Increases in forearm blood flow to the highest dose of acetylcholine and sodium nitroprusside were smaller (P < 0.05) in older sedentary (841 ± 142{\%}, 428 ± 74{\%}) compared with younger sedentary (1,519 ± 256{\%}, 925 ± 163{\%}) subjects. Similarly, increases in forearm blood flow to sodium nitroprusside (1 μg · 100 ml limb tissue-1 · min-1) were smaller (P < 0.05) in older endurance-trained (505 ± 110{\%}) compared with younger sedentary (925 ± 163{\%}) subjects. In contrast, no differences in leg blood flow responses to intra-arterial infusions of acetylcholine, substance P, or sodium nitroprusside were noted between subject groups. These results demonstrate that 1) acetylcholine-and sodium nitroprusside-induced vasodilation are attenuated in the forearm vasculature and preserved in the leg vasculature of older sedentary subjects and 2) sodium nitroprusside-induced vasodilation remains attenuated in the forearm vasculature of healthy older endurance-trained men but preserved in the leg vasculature of these men.",
author = "Newcomer, {Scan C.} and Urs Leuenberger and Hogeman, {Cynthia S.} and Proctor, {David Nathan}",
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T1 - Heterogeneous vasodilator responses of human limbs

T2 - Influence of age and habitual endurance training

AU - Newcomer, Scan C.

AU - Leuenberger, Urs

AU - Hogeman, Cynthia S.

AU - Proctor, David Nathan

PY - 2005/7/1

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N2 - Forearm endothelium-dependent vasodilation is impaired with age in sedentary, but not endurance-trained, men. The purpose of this investigation was to determine whether these age- and physical activity-related differences in endothelium-dependent vasodilation also occur in the leg. Brachial and common femoral arterial blood flow were measured with Doppler ultrasound during increasing doses of acetylcholine (1, 4, and 16 1 μg · 100 ml limb tissue-1 · min-1), substance P (8, 31, and 125 pg·100 ml limb tissue-1· min-1), and sodium nitroprusside (0.063, 0.25, and 1 μg · 100 ml limb tissue-1 · min-1) in 23 healthy men (8 younger sedentary, 8 older sedentary, and 7 older endurance trained). Increases in forearm blood flow to the highest dose of acetylcholine and sodium nitroprusside were smaller (P < 0.05) in older sedentary (841 ± 142%, 428 ± 74%) compared with younger sedentary (1,519 ± 256%, 925 ± 163%) subjects. Similarly, increases in forearm blood flow to sodium nitroprusside (1 μg · 100 ml limb tissue-1 · min-1) were smaller (P < 0.05) in older endurance-trained (505 ± 110%) compared with younger sedentary (925 ± 163%) subjects. In contrast, no differences in leg blood flow responses to intra-arterial infusions of acetylcholine, substance P, or sodium nitroprusside were noted between subject groups. These results demonstrate that 1) acetylcholine-and sodium nitroprusside-induced vasodilation are attenuated in the forearm vasculature and preserved in the leg vasculature of older sedentary subjects and 2) sodium nitroprusside-induced vasodilation remains attenuated in the forearm vasculature of healthy older endurance-trained men but preserved in the leg vasculature of these men.

AB - Forearm endothelium-dependent vasodilation is impaired with age in sedentary, but not endurance-trained, men. The purpose of this investigation was to determine whether these age- and physical activity-related differences in endothelium-dependent vasodilation also occur in the leg. Brachial and common femoral arterial blood flow were measured with Doppler ultrasound during increasing doses of acetylcholine (1, 4, and 16 1 μg · 100 ml limb tissue-1 · min-1), substance P (8, 31, and 125 pg·100 ml limb tissue-1· min-1), and sodium nitroprusside (0.063, 0.25, and 1 μg · 100 ml limb tissue-1 · min-1) in 23 healthy men (8 younger sedentary, 8 older sedentary, and 7 older endurance trained). Increases in forearm blood flow to the highest dose of acetylcholine and sodium nitroprusside were smaller (P < 0.05) in older sedentary (841 ± 142%, 428 ± 74%) compared with younger sedentary (1,519 ± 256%, 925 ± 163%) subjects. Similarly, increases in forearm blood flow to sodium nitroprusside (1 μg · 100 ml limb tissue-1 · min-1) were smaller (P < 0.05) in older endurance-trained (505 ± 110%) compared with younger sedentary (925 ± 163%) subjects. In contrast, no differences in leg blood flow responses to intra-arterial infusions of acetylcholine, substance P, or sodium nitroprusside were noted between subject groups. These results demonstrate that 1) acetylcholine-and sodium nitroprusside-induced vasodilation are attenuated in the forearm vasculature and preserved in the leg vasculature of older sedentary subjects and 2) sodium nitroprusside-induced vasodilation remains attenuated in the forearm vasculature of healthy older endurance-trained men but preserved in the leg vasculature of these men.

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JO - American Journal of Physiology

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