Heterosexual transmission of human immunodeficiency virus: Association with severe depletion of T-helper lymphocytes in men with hemophilia

J. J. Goedert, M. Elaine Eyster, R. J. Biggar, W. A. Blattner

    Research output: Contribution to journalArticle

    93 Citations (Scopus)

    Abstract

    We evaluated risk factors for human immunodeficiency virus (HIV) seropositivity in the wives/female sexual partners of hemophiliacs. One of the 6 seropositive women has developed the acquired immunodeficiency syndrome (AIDS). At least three of the others seroconverted during 1985-86, after more than four years of regular sexual contact with a seropositive hemophiliac. HIV seropositivity was present in at least 5 (50%) of the 10 female partners of hemophiliacs with severe depletion of T-helper cells (<100/μl), including 3 (43%) of the 7 female partners of hemophiliacs with AIDS. All 4 HIV seropositive women with available data had vaginal intercourse without a condom, but risk of seropositivity did not appear to be affected by the frequency of vaginal intercourse or by hysterectomy. Other sexually transmitted diseases, anal intercourse, or vaginal intercourse during menstrual periods were not necessary for HIV infection. These data suggest that heterosexual transmission of HIV can occur during routine vaginal intercourse but that it usually does not occur until the hemophiliac has severe immune deficiency late in the course of HIV infection.

    Original languageEnglish (US)
    Pages (from-to)355-361
    Number of pages7
    JournalAIDS Research and Human Retroviruses
    Volume3
    Issue number4
    DOIs
    StatePublished - Jan 1 1987

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    Heterosexuality
    Hemophilia A
    Helper-Inducer T-Lymphocytes
    HIV
    Virus Diseases
    Acquired Immunodeficiency Syndrome
    Sexual Partners
    Condoms
    Sexually Transmitted Diseases
    Hysterectomy
    Spouses

    All Science Journal Classification (ASJC) codes

    • Immunology
    • Virology
    • Infectious Diseases

    Cite this

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    abstract = "We evaluated risk factors for human immunodeficiency virus (HIV) seropositivity in the wives/female sexual partners of hemophiliacs. One of the 6 seropositive women has developed the acquired immunodeficiency syndrome (AIDS). At least three of the others seroconverted during 1985-86, after more than four years of regular sexual contact with a seropositive hemophiliac. HIV seropositivity was present in at least 5 (50{\%}) of the 10 female partners of hemophiliacs with severe depletion of T-helper cells (<100/μl), including 3 (43{\%}) of the 7 female partners of hemophiliacs with AIDS. All 4 HIV seropositive women with available data had vaginal intercourse without a condom, but risk of seropositivity did not appear to be affected by the frequency of vaginal intercourse or by hysterectomy. Other sexually transmitted diseases, anal intercourse, or vaginal intercourse during menstrual periods were not necessary for HIV infection. These data suggest that heterosexual transmission of HIV can occur during routine vaginal intercourse but that it usually does not occur until the hemophiliac has severe immune deficiency late in the course of HIV infection.",
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    Heterosexual transmission of human immunodeficiency virus : Association with severe depletion of T-helper lymphocytes in men with hemophilia. / Goedert, J. J.; Eyster, M. Elaine; Biggar, R. J.; Blattner, W. A.

    In: AIDS Research and Human Retroviruses, Vol. 3, No. 4, 01.01.1987, p. 355-361.

    Research output: Contribution to journalArticle

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