Heterotrimeric G-Protein-Coupled Signaling in Higher Plants

Lei Ding, Jin Gui Chen, Alan M. Jones, Sarah Mary Assmann

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Heterotrimeric G proteins are key signaling elements in eukaryotes. The fundamental building blocks of this pathway, the Gα, Gβ, and Gγ subunits, are encoded in plant genomes, as are regulator of G-protein signaling (RGS) proteins, and candidate seven-transmembrane (7TM) G-protein-coupled receptors (GPCRs). However, plants are distinguished fromother metazoans by having far fewer genes encoding these functions: for example, the genome of the model plant species Arabidopsis thaliana encodes single canonical Gα and Gβ subunits, two Gγ subunits, one RGS protein (which, unlike animal RGS proteins, contains a 7TM domain), and manyfewer candidateGPCRsthan mammalian genomes. Nevertheless, genetic approaches have demonstrated the importance of heterotrimeric G-protein signaling in a wide diversity of responses that are fundamental to plant growth and survival, including cell division, ion channel regulation, responses to most of the major plant hormones, and aspects of light signaling, oxidative stress, and pathogen response. These studies have also demonstrated that, similar to the situation in other eukaryotes, some responses are primarily mediated by the Gα subunit and others by the Gβ subunit (βγ dimer). The role that a given G-protein component plays in a given signaling process can differ between different plant cell types, as illustrated most thoroughly for regulation of cell division and hormonal response. These results imply that different plant cell types may employ different upstream and downstream proteins to couple with the heterotrimeric subunits. However, to date, only a few proteins have been shown to physically interact with plant G-protein subunits, and this is a fertile area for future research.

Original languageEnglish (US)
Title of host publicationAnnual Plant Reviews
Subtitle of host publicationIntracellular Signaling in Plants
Publisherwiley
Pages30-63
Number of pages34
Volume33
ISBN (Electronic)9781444302387
ISBN (Print)1405160020, 9781405160025
DOIs
StatePublished - Feb 9 2009

Fingerprint

RGS Proteins
Heterotrimeric GTP-Binding Proteins
G-proteins
Plant Genome
Plant Cells
Eukaryota
GTP-Binding Proteins
Cell Division
Plant Proteins
Plant Growth Regulators
Protein Subunits
Ion Channels
Arabidopsis
proteins
Proteins
Oxidative Stress
genome
eukaryotic cells
cell division
Genome

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)

Cite this

Ding, L., Chen, J. G., Jones, A. M., & Assmann, S. M. (2009). Heterotrimeric G-Protein-Coupled Signaling in Higher Plants. In Annual Plant Reviews: Intracellular Signaling in Plants (Vol. 33, pp. 30-63). wiley. https://doi.org/10.1002/9781444302387.ch2
Ding, Lei ; Chen, Jin Gui ; Jones, Alan M. ; Assmann, Sarah Mary. / Heterotrimeric G-Protein-Coupled Signaling in Higher Plants. Annual Plant Reviews: Intracellular Signaling in Plants. Vol. 33 wiley, 2009. pp. 30-63
@inbook{204d1a268a67420985ace9b9c507ccfc,
title = "Heterotrimeric G-Protein-Coupled Signaling in Higher Plants",
abstract = "Heterotrimeric G proteins are key signaling elements in eukaryotes. The fundamental building blocks of this pathway, the Gα, Gβ, and Gγ subunits, are encoded in plant genomes, as are regulator of G-protein signaling (RGS) proteins, and candidate seven-transmembrane (7TM) G-protein-coupled receptors (GPCRs). However, plants are distinguished fromother metazoans by having far fewer genes encoding these functions: for example, the genome of the model plant species Arabidopsis thaliana encodes single canonical Gα and Gβ subunits, two Gγ subunits, one RGS protein (which, unlike animal RGS proteins, contains a 7TM domain), and manyfewer candidateGPCRsthan mammalian genomes. Nevertheless, genetic approaches have demonstrated the importance of heterotrimeric G-protein signaling in a wide diversity of responses that are fundamental to plant growth and survival, including cell division, ion channel regulation, responses to most of the major plant hormones, and aspects of light signaling, oxidative stress, and pathogen response. These studies have also demonstrated that, similar to the situation in other eukaryotes, some responses are primarily mediated by the Gα subunit and others by the Gβ subunit (βγ dimer). The role that a given G-protein component plays in a given signaling process can differ between different plant cell types, as illustrated most thoroughly for regulation of cell division and hormonal response. These results imply that different plant cell types may employ different upstream and downstream proteins to couple with the heterotrimeric subunits. However, to date, only a few proteins have been shown to physically interact with plant G-protein subunits, and this is a fertile area for future research.",
author = "Lei Ding and Chen, {Jin Gui} and Jones, {Alan M.} and Assmann, {Sarah Mary}",
year = "2009",
month = "2",
day = "9",
doi = "10.1002/9781444302387.ch2",
language = "English (US)",
isbn = "1405160020",
volume = "33",
pages = "30--63",
booktitle = "Annual Plant Reviews",
publisher = "wiley",

}

Ding, L, Chen, JG, Jones, AM & Assmann, SM 2009, Heterotrimeric G-Protein-Coupled Signaling in Higher Plants. in Annual Plant Reviews: Intracellular Signaling in Plants. vol. 33, wiley, pp. 30-63. https://doi.org/10.1002/9781444302387.ch2

Heterotrimeric G-Protein-Coupled Signaling in Higher Plants. / Ding, Lei; Chen, Jin Gui; Jones, Alan M.; Assmann, Sarah Mary.

Annual Plant Reviews: Intracellular Signaling in Plants. Vol. 33 wiley, 2009. p. 30-63.

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - Heterotrimeric G-Protein-Coupled Signaling in Higher Plants

AU - Ding, Lei

AU - Chen, Jin Gui

AU - Jones, Alan M.

AU - Assmann, Sarah Mary

PY - 2009/2/9

Y1 - 2009/2/9

N2 - Heterotrimeric G proteins are key signaling elements in eukaryotes. The fundamental building blocks of this pathway, the Gα, Gβ, and Gγ subunits, are encoded in plant genomes, as are regulator of G-protein signaling (RGS) proteins, and candidate seven-transmembrane (7TM) G-protein-coupled receptors (GPCRs). However, plants are distinguished fromother metazoans by having far fewer genes encoding these functions: for example, the genome of the model plant species Arabidopsis thaliana encodes single canonical Gα and Gβ subunits, two Gγ subunits, one RGS protein (which, unlike animal RGS proteins, contains a 7TM domain), and manyfewer candidateGPCRsthan mammalian genomes. Nevertheless, genetic approaches have demonstrated the importance of heterotrimeric G-protein signaling in a wide diversity of responses that are fundamental to plant growth and survival, including cell division, ion channel regulation, responses to most of the major plant hormones, and aspects of light signaling, oxidative stress, and pathogen response. These studies have also demonstrated that, similar to the situation in other eukaryotes, some responses are primarily mediated by the Gα subunit and others by the Gβ subunit (βγ dimer). The role that a given G-protein component plays in a given signaling process can differ between different plant cell types, as illustrated most thoroughly for regulation of cell division and hormonal response. These results imply that different plant cell types may employ different upstream and downstream proteins to couple with the heterotrimeric subunits. However, to date, only a few proteins have been shown to physically interact with plant G-protein subunits, and this is a fertile area for future research.

AB - Heterotrimeric G proteins are key signaling elements in eukaryotes. The fundamental building blocks of this pathway, the Gα, Gβ, and Gγ subunits, are encoded in plant genomes, as are regulator of G-protein signaling (RGS) proteins, and candidate seven-transmembrane (7TM) G-protein-coupled receptors (GPCRs). However, plants are distinguished fromother metazoans by having far fewer genes encoding these functions: for example, the genome of the model plant species Arabidopsis thaliana encodes single canonical Gα and Gβ subunits, two Gγ subunits, one RGS protein (which, unlike animal RGS proteins, contains a 7TM domain), and manyfewer candidateGPCRsthan mammalian genomes. Nevertheless, genetic approaches have demonstrated the importance of heterotrimeric G-protein signaling in a wide diversity of responses that are fundamental to plant growth and survival, including cell division, ion channel regulation, responses to most of the major plant hormones, and aspects of light signaling, oxidative stress, and pathogen response. These studies have also demonstrated that, similar to the situation in other eukaryotes, some responses are primarily mediated by the Gα subunit and others by the Gβ subunit (βγ dimer). The role that a given G-protein component plays in a given signaling process can differ between different plant cell types, as illustrated most thoroughly for regulation of cell division and hormonal response. These results imply that different plant cell types may employ different upstream and downstream proteins to couple with the heterotrimeric subunits. However, to date, only a few proteins have been shown to physically interact with plant G-protein subunits, and this is a fertile area for future research.

UR - http://www.scopus.com/inward/record.url?scp=84947713061&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84947713061&partnerID=8YFLogxK

U2 - 10.1002/9781444302387.ch2

DO - 10.1002/9781444302387.ch2

M3 - Chapter

SN - 1405160020

SN - 9781405160025

VL - 33

SP - 30

EP - 63

BT - Annual Plant Reviews

PB - wiley

ER -

Ding L, Chen JG, Jones AM, Assmann SM. Heterotrimeric G-Protein-Coupled Signaling in Higher Plants. In Annual Plant Reviews: Intracellular Signaling in Plants. Vol. 33. wiley. 2009. p. 30-63 https://doi.org/10.1002/9781444302387.ch2