High concentrations of 17β-estradiol attenuate the exercise pressor reflex in male cats

Petra M. Schmitt, Marc Kaufman

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Previously, intravenous injection of 17β-estradiol in decerebrate male cats was found to attenuate central command but not the exercise pressor reflex. This latter finding was surprising because the dorsal horn, the spinal site receiving synaptic input from thin-fiber muscle afferents, is known to contain estrogen receptors. We were prompted, therefore, to reexamine this issue. Instead of injecting 17β-estradiol intravenously, we applied it topically to the L7 and S1 spinal cord of male decerebrate cats. We found that topical application (150-200 μl) of 17β-estradiol in concentrations of 0.01, 0.1, and 1 μg/ml had no effect on the exercise pressor reflex, whereas a concentration of 10 μg/ml attenuated the reflex. We conclude that, in male cats, estrogen can only attenuate the exercise pressor reflex in concentrations that exceed the physiological level.

Original languageEnglish (US)
Pages (from-to)1431-1436
Number of pages6
JournalJournal of Applied Physiology
Volume94
Issue number4
DOIs
StatePublished - Apr 1 2003

Fingerprint

Reflex
Estradiol
Cats
Intravenous Injections
Estrogen Receptors
Spinal Cord
Estrogens
Muscles

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

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abstract = "Previously, intravenous injection of 17β-estradiol in decerebrate male cats was found to attenuate central command but not the exercise pressor reflex. This latter finding was surprising because the dorsal horn, the spinal site receiving synaptic input from thin-fiber muscle afferents, is known to contain estrogen receptors. We were prompted, therefore, to reexamine this issue. Instead of injecting 17β-estradiol intravenously, we applied it topically to the L7 and S1 spinal cord of male decerebrate cats. We found that topical application (150-200 μl) of 17β-estradiol in concentrations of 0.01, 0.1, and 1 μg/ml had no effect on the exercise pressor reflex, whereas a concentration of 10 μg/ml attenuated the reflex. We conclude that, in male cats, estrogen can only attenuate the exercise pressor reflex in concentrations that exceed the physiological level.",
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High concentrations of 17β-estradiol attenuate the exercise pressor reflex in male cats. / Schmitt, Petra M.; Kaufman, Marc.

In: Journal of Applied Physiology, Vol. 94, No. 4, 01.04.2003, p. 1431-1436.

Research output: Contribution to journalArticle

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