TY - JOUR
T1 - High dietary glycemic load is associated with increased risk of colon cancer
AU - Zelenskiy, Svetlana
AU - Thompson, Cheryl L.
AU - Tucker, Thomas C.
AU - Li, Li
N1 - Funding Information:
This work was supported by the Damon Runyon Cancer Research Foundation Clinical Investigator Award (CI-8) and the National Institutes of Health Grant (R01 CA136726).
PY - 2014/4/3
Y1 - 2014/4/3
N2 - High dietary glycemic load (GL) has been inconsistently associated with risk of colon cancer. We analyzed data for 1093 incident cases and 1589 controls in a population-based case-control study of colon cancer to further clarify the GL-colon cancer relationship. GL was assessed using a self-administered food frequency questionnaire. Cases had a significantly higher GL intake (mean = 136.4, SD = 24.5) than controls (mean = 132.8, SD = 25.2) (P = 0.0003). In a multivariate unconditional logistic regression model, the odds ratios (ORs) for colon cancer increased significantly with increasing GL: compared to the bottom quartile of GL, the ORs (95% CI) for the 2nd through the upper quartiles were 1.38 (1.06, 1.80), 1.67 (1.30, 2.13), and 1.61 (1.25, 2.07), respectively (Ptrend < 0.0001). Stratified analyses showed that the association was more pronounced among older participants [ORs (95% CI) for the 2nd through the upper quartiles were 1.35 (0.91, 2.00), 1.87 (1.29, 2.71), 2.02 (1.39, 2.95), respectively] than among younger participants [ORs were 1.46 (1.02, 2.10), 1.53 (1.09, 2.15), and 1.35 (0.96, 1.91), respectively] (Pint = 0.02). Our results provide support for the hypothesis that a diet with high GL increases the risk of colon cancer.
AB - High dietary glycemic load (GL) has been inconsistently associated with risk of colon cancer. We analyzed data for 1093 incident cases and 1589 controls in a population-based case-control study of colon cancer to further clarify the GL-colon cancer relationship. GL was assessed using a self-administered food frequency questionnaire. Cases had a significantly higher GL intake (mean = 136.4, SD = 24.5) than controls (mean = 132.8, SD = 25.2) (P = 0.0003). In a multivariate unconditional logistic regression model, the odds ratios (ORs) for colon cancer increased significantly with increasing GL: compared to the bottom quartile of GL, the ORs (95% CI) for the 2nd through the upper quartiles were 1.38 (1.06, 1.80), 1.67 (1.30, 2.13), and 1.61 (1.25, 2.07), respectively (Ptrend < 0.0001). Stratified analyses showed that the association was more pronounced among older participants [ORs (95% CI) for the 2nd through the upper quartiles were 1.35 (0.91, 2.00), 1.87 (1.29, 2.71), 2.02 (1.39, 2.95), respectively] than among younger participants [ORs were 1.46 (1.02, 2.10), 1.53 (1.09, 2.15), and 1.35 (0.96, 1.91), respectively] (Pint = 0.02). Our results provide support for the hypothesis that a diet with high GL increases the risk of colon cancer.
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U2 - 10.1080/01635581.2014.884231
DO - 10.1080/01635581.2014.884231
M3 - Article
C2 - 24611536
AN - SCOPUS:84897390350
SN - 0163-5581
VL - 66
SP - 362
EP - 368
JO - Nutrition and Cancer
JF - Nutrition and Cancer
IS - 3
ER -