High genetic similarity of ciprofloxacin-resistant Campylobacter jejuni in central Europe

Jasna Kovac, Neža Čadež, Beatrix Stessl, Kerstin Stingl, Igor Gruntar, Matjaž Ocepek, Marija Trkov, Martin Wagner, Sonja Smole Možina

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Campylobacteriosis is the leading zoonosis in the European Union with the majority of cases attributed to Campylobacter jejuni. Although the disease is usually self-limiting, some severe cases need to be treated with antibiotics, primarily macrolides and quinolones. However, the resistance to the latter is reaching alarming levels in most of the EU countries. To shed light on the expansion of antibiotic resistance in central Europe, we have investigated genetic similarity across 178 ciprofloxacin-resistant C. jejuni mostly isolated in Slovenia, Austria and Germany. We performed comparative genetic similarity analyses using allelic types of seven multilocus sequence typing housekeeping genes, and single nucleotide polymorphisms of a quinolone resistance determining region located within the DNA gyrase subunit A gene. This analysis revealed high genetic similarity of isolates from clonal complex ST-21 that carry gyrA allelic type 1 in all three of these central-European countries, suggesting these ciprofloxacin resistant isolates arose from a recent common ancestor and are spread clonally.

Original languageEnglish (US)
Article number01169
JournalFrontiers in Microbiology
Volume6
Issue numberOCT
DOIs
StatePublished - Jan 1 2015

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Campylobacter jejuni
Quinolones
Ciprofloxacin
DNA Gyrase
Slovenia
Multilocus Sequence Typing
Austria
Essential Genes
Macrolides
Zoonoses
European Union
Microbial Drug Resistance
Single Nucleotide Polymorphism
Germany
Anti-Bacterial Agents
Genes
pivcephalexin

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)

Cite this

Kovac, J., Čadež, N., Stessl, B., Stingl, K., Gruntar, I., Ocepek, M., ... Možina, S. S. (2015). High genetic similarity of ciprofloxacin-resistant Campylobacter jejuni in central Europe. Frontiers in Microbiology, 6(OCT), [01169]. https://doi.org/10.3389/fmicb.2015.01169
Kovac, Jasna ; Čadež, Neža ; Stessl, Beatrix ; Stingl, Kerstin ; Gruntar, Igor ; Ocepek, Matjaž ; Trkov, Marija ; Wagner, Martin ; Možina, Sonja Smole. / High genetic similarity of ciprofloxacin-resistant Campylobacter jejuni in central Europe. In: Frontiers in Microbiology. 2015 ; Vol. 6, No. OCT.
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Kovac, J, Čadež, N, Stessl, B, Stingl, K, Gruntar, I, Ocepek, M, Trkov, M, Wagner, M & Možina, SS 2015, 'High genetic similarity of ciprofloxacin-resistant Campylobacter jejuni in central Europe', Frontiers in Microbiology, vol. 6, no. OCT, 01169. https://doi.org/10.3389/fmicb.2015.01169

High genetic similarity of ciprofloxacin-resistant Campylobacter jejuni in central Europe. / Kovac, Jasna; Čadež, Neža; Stessl, Beatrix; Stingl, Kerstin; Gruntar, Igor; Ocepek, Matjaž; Trkov, Marija; Wagner, Martin; Možina, Sonja Smole.

In: Frontiers in Microbiology, Vol. 6, No. OCT, 01169, 01.01.2015.

Research output: Contribution to journalArticle

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