Abstract
Background: Because the prognosis of high-grade aneurysmal subarachnoid hemorrhage (aSAH), classified as World Federation of Neurosurgical Societies (WFNS) grade IV–V, is generally poor, the functional outcomes of survivors have not been thoroughly explored. The aim of this retrospective cohort study is to determine predictors of functional independence in patients who survive a high-grade aSAH. Methods: We retrospectively evaluated consecutive patients with aSAH admitted to a single institution from January 2000 to April 2015. Adult (age ≥18 years) patients with WFNS grade IV–V aSAH were included for analysis. Patients without sufficient baseline data, those who died before discharge, and those without follow-up data were excluded. Univariable and multivariable logistic regression analyses were used to identify factors associated with functional independence, defined as a modified Rankin Scale score of 0–2, at last follow-up. Results: Of the 260 patients with a WFNS grade IV–V aSAH during the study period, 139 met the inclusion criteria. After a mean follow-up of 6.3 months, functional independence was achieved in 73% of high-grade aSAH survivors (101/139 patients) and in 39% of all high-grade aSAH cases (101/260 patients). Only a lack of cerebrospinal fluid shunt placement was found to be an independent predictor of functional independence in the multivariable analysis (odds ratio 0.28 [0.109–0.722]; P = 0.008). Conclusions: Because functional independence can be achieved in the majority of high-grade aSAH survivors, aggressive initial management of high-grade aSAH is warranted. Strategies that reduce the need for permanent cerebrospinal fluid diversion may improve functional outcomes in survivors of high-grade aSAH.
| Original language | English (US) |
|---|---|
| Pages (from-to) | e723-e728 |
| Journal | World neurosurgery |
| Volume | 125 |
| DOIs | |
| State | Published - May 2019 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Clinical Neurology
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High-Grade Aneurysmal Subarachnoid Hemorrhage : Predictors of Functional Outcome. / Ironside, Natasha; Buell, Thomas J.; Chen, Ching Jen; Kumar, Jeyan S.; Paisan, Gabriella M.; Sokolowski, Jennifer D.; Liu, Kenneth C.; Ding, Dale.
In: World neurosurgery, Vol. 125, 05.2019, p. e723-e728.Research output: Contribution to journal › Article
TY - JOUR
T1 - High-Grade Aneurysmal Subarachnoid Hemorrhage
T2 - Predictors of Functional Outcome
AU - Ironside, Natasha
AU - Buell, Thomas J.
AU - Chen, Ching Jen
AU - Kumar, Jeyan S.
AU - Paisan, Gabriella M.
AU - Sokolowski, Jennifer D.
AU - Liu, Kenneth C.
AU - Ding, Dale
PY - 2019/5
Y1 - 2019/5
N2 - Background: Because the prognosis of high-grade aneurysmal subarachnoid hemorrhage (aSAH), classified as World Federation of Neurosurgical Societies (WFNS) grade IV–V, is generally poor, the functional outcomes of survivors have not been thoroughly explored. The aim of this retrospective cohort study is to determine predictors of functional independence in patients who survive a high-grade aSAH. Methods: We retrospectively evaluated consecutive patients with aSAH admitted to a single institution from January 2000 to April 2015. Adult (age ≥18 years) patients with WFNS grade IV–V aSAH were included for analysis. Patients without sufficient baseline data, those who died before discharge, and those without follow-up data were excluded. Univariable and multivariable logistic regression analyses were used to identify factors associated with functional independence, defined as a modified Rankin Scale score of 0–2, at last follow-up. Results: Of the 260 patients with a WFNS grade IV–V aSAH during the study period, 139 met the inclusion criteria. After a mean follow-up of 6.3 months, functional independence was achieved in 73% of high-grade aSAH survivors (101/139 patients) and in 39% of all high-grade aSAH cases (101/260 patients). Only a lack of cerebrospinal fluid shunt placement was found to be an independent predictor of functional independence in the multivariable analysis (odds ratio 0.28 [0.109–0.722]; P = 0.008). Conclusions: Because functional independence can be achieved in the majority of high-grade aSAH survivors, aggressive initial management of high-grade aSAH is warranted. Strategies that reduce the need for permanent cerebrospinal fluid diversion may improve functional outcomes in survivors of high-grade aSAH.
AB - Background: Because the prognosis of high-grade aneurysmal subarachnoid hemorrhage (aSAH), classified as World Federation of Neurosurgical Societies (WFNS) grade IV–V, is generally poor, the functional outcomes of survivors have not been thoroughly explored. The aim of this retrospective cohort study is to determine predictors of functional independence in patients who survive a high-grade aSAH. Methods: We retrospectively evaluated consecutive patients with aSAH admitted to a single institution from January 2000 to April 2015. Adult (age ≥18 years) patients with WFNS grade IV–V aSAH were included for analysis. Patients without sufficient baseline data, those who died before discharge, and those without follow-up data were excluded. Univariable and multivariable logistic regression analyses were used to identify factors associated with functional independence, defined as a modified Rankin Scale score of 0–2, at last follow-up. Results: Of the 260 patients with a WFNS grade IV–V aSAH during the study period, 139 met the inclusion criteria. After a mean follow-up of 6.3 months, functional independence was achieved in 73% of high-grade aSAH survivors (101/139 patients) and in 39% of all high-grade aSAH cases (101/260 patients). Only a lack of cerebrospinal fluid shunt placement was found to be an independent predictor of functional independence in the multivariable analysis (odds ratio 0.28 [0.109–0.722]; P = 0.008). Conclusions: Because functional independence can be achieved in the majority of high-grade aSAH survivors, aggressive initial management of high-grade aSAH is warranted. Strategies that reduce the need for permanent cerebrospinal fluid diversion may improve functional outcomes in survivors of high-grade aSAH.
UR - http://www.scopus.com/inward/record.url?scp=85062012051&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85062012051&partnerID=8YFLogxK
U2 - 10.1016/j.wneu.2019.01.162
DO - 10.1016/j.wneu.2019.01.162
M3 - Article
C2 - 30735864
AN - SCOPUS:85062012051
VL - 125
SP - e723-e728
JO - World Neurosurgery
JF - World Neurosurgery
SN - 1878-8750
ER -