Abstract
Purified phenolic glycolipid (PGL-1) from Mycobacterium leprae was used to detect IgG antibodies against PGL-1 in leprosy patients in an enzyme- linked immunosorbent assay (ELISA). A total of 698 sera were screened; they came from patients suffering from leprosy, autoimmune disease, myeloma, tuberculosis and sexually transmitted diseases (STDs). Cases with miscellaneous diseases and persons undergoing AIDS screening were also included. Sera from lepromatous and tuberculoid leprosy patients gave positivity rates of 60.5% and 41.7%, respectively. In non-leprosy cases, the PGL-1 ELISA showed an overall positivity rate of 6.9%; this was greatest in patients with tuberculosis (43.8%) followed by autoimmune diseases (40.9%) and miscellaneous cases including liver diseases (37.9%). This study emphasizes that PGL-1 ELISA has a low predictive value for diagnosis of active infection by Mycobacterium leprae. Positive reactions in a significant percentage of patients with autoimmune disease are intriguing and need indepth study.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 238-241 |
| Number of pages | 4 |
| Journal | Journal of Dermatology |
| Volume | 25 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1998 |
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All Science Journal Classification (ASJC) codes
- Dermatology
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High incidence of IgG antibodies to phenolic glycolipid in non-leprosy patients in India. / Kumar, Bhushan; Sinha, Raghu; Sehgal, Shobha.
In: Journal of Dermatology, Vol. 25, No. 4, 04.1998, p. 238-241.Research output: Contribution to journal › Article
TY - JOUR
T1 - High incidence of IgG antibodies to phenolic glycolipid in non-leprosy patients in India
AU - Kumar, Bhushan
AU - Sinha, Raghu
AU - Sehgal, Shobha
PY - 1998/4
Y1 - 1998/4
N2 - Purified phenolic glycolipid (PGL-1) from Mycobacterium leprae was used to detect IgG antibodies against PGL-1 in leprosy patients in an enzyme- linked immunosorbent assay (ELISA). A total of 698 sera were screened; they came from patients suffering from leprosy, autoimmune disease, myeloma, tuberculosis and sexually transmitted diseases (STDs). Cases with miscellaneous diseases and persons undergoing AIDS screening were also included. Sera from lepromatous and tuberculoid leprosy patients gave positivity rates of 60.5% and 41.7%, respectively. In non-leprosy cases, the PGL-1 ELISA showed an overall positivity rate of 6.9%; this was greatest in patients with tuberculosis (43.8%) followed by autoimmune diseases (40.9%) and miscellaneous cases including liver diseases (37.9%). This study emphasizes that PGL-1 ELISA has a low predictive value for diagnosis of active infection by Mycobacterium leprae. Positive reactions in a significant percentage of patients with autoimmune disease are intriguing and need indepth study.
AB - Purified phenolic glycolipid (PGL-1) from Mycobacterium leprae was used to detect IgG antibodies against PGL-1 in leprosy patients in an enzyme- linked immunosorbent assay (ELISA). A total of 698 sera were screened; they came from patients suffering from leprosy, autoimmune disease, myeloma, tuberculosis and sexually transmitted diseases (STDs). Cases with miscellaneous diseases and persons undergoing AIDS screening were also included. Sera from lepromatous and tuberculoid leprosy patients gave positivity rates of 60.5% and 41.7%, respectively. In non-leprosy cases, the PGL-1 ELISA showed an overall positivity rate of 6.9%; this was greatest in patients with tuberculosis (43.8%) followed by autoimmune diseases (40.9%) and miscellaneous cases including liver diseases (37.9%). This study emphasizes that PGL-1 ELISA has a low predictive value for diagnosis of active infection by Mycobacterium leprae. Positive reactions in a significant percentage of patients with autoimmune disease are intriguing and need indepth study.
UR - http://www.scopus.com/inward/record.url?scp=0031966908&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031966908&partnerID=8YFLogxK
U2 - 10.1111/j.1346-8138.1998.tb02388.x
DO - 10.1111/j.1346-8138.1998.tb02388.x
M3 - Article
C2 - 9609981
AN - SCOPUS:0031966908
VL - 25
SP - 238
EP - 241
JO - Journal of Dermatology
JF - Journal of Dermatology
SN - 0385-2407
IS - 4
ER -