High-performance silicon nanopore hemofiltration membranes

William H. Fissell, Anna Dubnisheva, Abigail N. Eldridge, Aaron J. Fleischman, Andrew L. Zydney, Shuvo Roy

Research output: Contribution to journalArticlepeer-review

118 Scopus citations

Abstract

Silicon micromachining provides the precise control of nanoscale features that can be fundamentally enabling for miniaturized, implantable medical devices. Concerns have been raised regarding blood biocompatibility of silicon-based materials and their application to hemodialysis and hemofiltration. A high-performance ultrathin hemofiltration membrane with monodisperse slit-shaped pores was fabricated using a sacrificial oxide technique and then surface-modified with poly(ethylene glycol) (PEG). Fluid and macromolecular transport matched model predictions well. Protein adsorption, fouling, and thrombosis were significantly inhibited by the PEG. The membrane retained hydraulic permeability and molecular selectivity during a 90-h hemofiltration experiment with anticoagulated bovine whole blood. This is the first report of successful prolonged hemofiltration with a silicon nanopore membrane. The results demonstrate feasibility of renal replacement devices based on these membranes and materials.

Original languageEnglish (US)
Pages (from-to)58-63
Number of pages6
JournalJournal of Membrane Science
Volume326
Issue number1
DOIs
StatePublished - Jan 5 2009

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Materials Science(all)
  • Physical and Theoretical Chemistry
  • Filtration and Separation

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