High rate of mobilization for blaCTX-MS

Miriam Barlow; Rebecca A. Reik; Stephen D. Jacobs; Mónica Medina; Matthew P. Meyer; John E. McGowan; Fred C. Tenover

doi:10.3201/eid1403.070405

High rate of mobilization for bla_CTX-MS

Miriam Barlow, Rebecca A. Reik, Stephen D. Jacobs, Mónica Medina, Matthew P. Meyer, John E. McGowan, Fred C. Tenover

Biology

Research output: Contribution to journal › Article

37 Scopus citations

Abstract

We constructed a phylogenetic analysis of class A β-lactamases and found that the bla_CTX-Ms have been mobilized to plasmids ≈10 times more frequently than other class A β-lactamases. We also found that the bla_CTX-Ms are descended from a common ancestor that was incorporated in ancient times into the chromosome of the ancestor of Kluyvera species through horizontal transfer. Considerable sequence divergence has occurred among the descendents of that ancestral gene sequence since that gene was inserted. That divergence has mainly occurred in the presence of purifying selection, which indicates a slow rate of evolution for bla_CTX-Ms in the pre-antimicrobial drug era.

Original language	English (US)
Pages (from-to)	423-428
Number of pages	6
Journal	Emerging infectious diseases
Volume	14
Issue number	3
DOIs	https://doi.org/10.3201/eid1403.070405
State	Published - Mar 2008

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All Science Journal Classification (ASJC) codes

Epidemiology
Microbiology (medical)
Infectious Diseases

Cite this

Barlow, M., Reik, R. A., Jacobs, S. D., Medina, M., Meyer, M. P., McGowan, J. E., & Tenover, F. C. (2008). High rate of mobilization for bla_CTX-MS. Emerging infectious diseases, 14(3), 423-428. https://doi.org/10.3201/eid1403.070405

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AU - McGowan, John E.

AU - Tenover, Fred C.

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10.3201/eid1403.070405