High rate of mobilization for blaCTX-MS

Miriam Barlow, Rebecca A. Reik, Stephen D. Jacobs, Mónica Medina, Matthew P. Meyer, John E. McGowan, Fred C. Tenover

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

We constructed a phylogenetic analysis of class A β-lactamases and found that the blaCTX-Ms have been mobilized to plasmids ≈10 times more frequently than other class A β-lactamases. We also found that the blaCTX-Ms are descended from a common ancestor that was incorporated in ancient times into the chromosome of the ancestor of Kluyvera species through horizontal transfer. Considerable sequence divergence has occurred among the descendents of that ancestral gene sequence since that gene was inserted. That divergence has mainly occurred in the presence of purifying selection, which indicates a slow rate of evolution for blaCTX-Ms in the pre-antimicrobial drug era.

Original languageEnglish (US)
Pages (from-to)423-428
Number of pages6
JournalEmerging infectious diseases
Volume14
Issue number3
DOIs
StatePublished - Mar 2008

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

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