Abstract
We constructed a phylogenetic analysis of class A β-lactamases and found that the blaCTX-Ms have been mobilized to plasmids ≈10 times more frequently than other class A β-lactamases. We also found that the blaCTX-Ms are descended from a common ancestor that was incorporated in ancient times into the chromosome of the ancestor of Kluyvera species through horizontal transfer. Considerable sequence divergence has occurred among the descendents of that ancestral gene sequence since that gene was inserted. That divergence has mainly occurred in the presence of purifying selection, which indicates a slow rate of evolution for blaCTX-Ms in the pre-antimicrobial drug era.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 423-428 |
| Number of pages | 6 |
| Journal | Emerging infectious diseases |
| Volume | 14 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 2008 |
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All Science Journal Classification (ASJC) codes
- Epidemiology
- Microbiology (medical)
- Infectious Diseases
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High rate of mobilization for blaCTX-MS. / Barlow, Miriam; Reik, Rebecca A.; Jacobs, Stephen D.; Medina, Monica; Meyer, Matthew P.; McGowan, John E.; Tenover, Fred C.
In: Emerging infectious diseases, Vol. 14, No. 3, 01.01.2008, p. 423-428.Research output: Contribution to journal › Article
TY - JOUR
T1 - High rate of mobilization for blaCTX-MS
AU - Barlow, Miriam
AU - Reik, Rebecca A.
AU - Jacobs, Stephen D.
AU - Medina, Monica
AU - Meyer, Matthew P.
AU - McGowan, John E.
AU - Tenover, Fred C.
PY - 2008/1/1
Y1 - 2008/1/1
N2 - We constructed a phylogenetic analysis of class A β-lactamases and found that the blaCTX-Ms have been mobilized to plasmids ≈10 times more frequently than other class A β-lactamases. We also found that the blaCTX-Ms are descended from a common ancestor that was incorporated in ancient times into the chromosome of the ancestor of Kluyvera species through horizontal transfer. Considerable sequence divergence has occurred among the descendents of that ancestral gene sequence since that gene was inserted. That divergence has mainly occurred in the presence of purifying selection, which indicates a slow rate of evolution for blaCTX-Ms in the pre-antimicrobial drug era.
AB - We constructed a phylogenetic analysis of class A β-lactamases and found that the blaCTX-Ms have been mobilized to plasmids ≈10 times more frequently than other class A β-lactamases. We also found that the blaCTX-Ms are descended from a common ancestor that was incorporated in ancient times into the chromosome of the ancestor of Kluyvera species through horizontal transfer. Considerable sequence divergence has occurred among the descendents of that ancestral gene sequence since that gene was inserted. That divergence has mainly occurred in the presence of purifying selection, which indicates a slow rate of evolution for blaCTX-Ms in the pre-antimicrobial drug era.
UR - http://www.scopus.com/inward/record.url?scp=41349088401&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=41349088401&partnerID=8YFLogxK
U2 - 10.3201/eid1403.070405
DO - 10.3201/eid1403.070405
M3 - Article
VL - 14
SP - 423
EP - 428
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
SN - 1080-6040
IS - 3
ER -