High-resolution MR imaging of the rat spinal cord in vivo in a wide-bore magnet at 17.6 Tesla

V. C. Behr, T. Weber, T. Neuberger, M. Vroemen, N. Weidner, U. Bogdahn, A. Haase, P. M. Jakob, C. Faber

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The objective was to demonstrate the feasibility and to evaluate the performance of high-resolution in vivo magnetic resonance (MR) imaging of the rat spinal cord in a 17.6-T vertical wide-bore magnet. A probehead consisting of a surface coil that offers enlarged sample volume suitable for rats up to a weight of 220 g was designed. ECG triggered and respiratory-gated gradient echo experiments were performed on a Bruker Avance 750 wide-bore spectrometer for high-resolution imaging. With T2* values between 5 and 20 ms, good image contrast could be obtained using short echo times, which also minimizes motion artifacts. Anatomy of healthy spinal cords and pathomorphological changes in traumatically injured rat spinal cord in vivo could be visualized with microscopic detail. It was demonstrated that imaging of the rat spinal cord in vivo using a vertical wide-bore high-magnetic-field system is feasible. The potential to obtain high-resolution images in short scan times renders high-field imaging a powerful diagnostic tool.

Original languageEnglish (US)
Pages (from-to)353-358
Number of pages6
JournalMagnetic Resonance Materials in Physics, Biology and Medicine
Volume17
Issue number3-6
DOIs
StatePublished - Dec 2004

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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