Higher iron in the red nucleus marks Parkinson's dyskinesia

Mechelle Lewis, Guangwei Du, Michal Kidacki, Nisargkumar Patel, Michele L. Shaffer, Richard Mailman, Xuemei Huang

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Dopamine cell loss and increased iron in the substantia nigra (SN) characterize Parkinson's disease (PD), with cerebellar involvement increasingly recognized, particularly in motor compensation and levodopa-induced dyskinesia (LID) development. Because the red nucleus (RN) mediates cerebellar circuitry, we hypothesized that RN iron changes might reflect cerebellum-related compensation, and/or the intrinsic capacity for LID development. We acquired high resolution magnetic resonance images from 23 control and 38 PD subjects (12 with PD and history of LID [PD+DYS]) and 26 with PD and no history of LID (PD-DYS). Iron content was estimated from bilateral RN and SN transverse relaxation rates (R2*). PD subjects overall displayed higher R2* values in both the SN and RN. RN R2* values correlated with off-drug Unified Parkinson's Disease Rating Scale-motor scores, but not disease duration or drug dosage. RN R2* values were significantly higher in PD+DYS compared with control and PD-DYS subjects; control and PD-DYS subjects did not differ. The association of higher RN iron content with PD-related dyskinesia suggests increased iron content is involved in, or reflects, greater cerebellar compensatory capacity and thus increased likelihood of LID development.

Original languageEnglish (US)
Pages (from-to)1497-1503
Number of pages7
JournalNeurobiology of Aging
Volume34
Issue number5
DOIs
StatePublished - May 1 2013

Fingerprint

Red Nucleus
Dyskinesias
Parkinson Disease
Iron
Levodopa
Substantia Nigra
Pharmaceutical Preparations
Cerebellum
Dopamine
Magnetic Resonance Spectroscopy

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Lewis, Mechelle ; Du, Guangwei ; Kidacki, Michal ; Patel, Nisargkumar ; Shaffer, Michele L. ; Mailman, Richard ; Huang, Xuemei. / Higher iron in the red nucleus marks Parkinson's dyskinesia. In: Neurobiology of Aging. 2013 ; Vol. 34, No. 5. pp. 1497-1503.
@article{bccfec48386f4283b15e1f8a713bd072,
title = "Higher iron in the red nucleus marks Parkinson's dyskinesia",
abstract = "Dopamine cell loss and increased iron in the substantia nigra (SN) characterize Parkinson's disease (PD), with cerebellar involvement increasingly recognized, particularly in motor compensation and levodopa-induced dyskinesia (LID) development. Because the red nucleus (RN) mediates cerebellar circuitry, we hypothesized that RN iron changes might reflect cerebellum-related compensation, and/or the intrinsic capacity for LID development. We acquired high resolution magnetic resonance images from 23 control and 38 PD subjects (12 with PD and history of LID [PD+DYS]) and 26 with PD and no history of LID (PD-DYS). Iron content was estimated from bilateral RN and SN transverse relaxation rates (R2*). PD subjects overall displayed higher R2* values in both the SN and RN. RN R2* values correlated with off-drug Unified Parkinson's Disease Rating Scale-motor scores, but not disease duration or drug dosage. RN R2* values were significantly higher in PD+DYS compared with control and PD-DYS subjects; control and PD-DYS subjects did not differ. The association of higher RN iron content with PD-related dyskinesia suggests increased iron content is involved in, or reflects, greater cerebellar compensatory capacity and thus increased likelihood of LID development.",
author = "Mechelle Lewis and Guangwei Du and Michal Kidacki and Nisargkumar Patel and Shaffer, {Michele L.} and Richard Mailman and Xuemei Huang",
year = "2013",
month = "5",
day = "1",
doi = "10.1016/j.neurobiolaging.2012.10.025",
language = "English (US)",
volume = "34",
pages = "1497--1503",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "5",

}

Higher iron in the red nucleus marks Parkinson's dyskinesia. / Lewis, Mechelle; Du, Guangwei; Kidacki, Michal; Patel, Nisargkumar; Shaffer, Michele L.; Mailman, Richard; Huang, Xuemei.

In: Neurobiology of Aging, Vol. 34, No. 5, 01.05.2013, p. 1497-1503.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Higher iron in the red nucleus marks Parkinson's dyskinesia

AU - Lewis, Mechelle

AU - Du, Guangwei

AU - Kidacki, Michal

AU - Patel, Nisargkumar

AU - Shaffer, Michele L.

AU - Mailman, Richard

AU - Huang, Xuemei

PY - 2013/5/1

Y1 - 2013/5/1

N2 - Dopamine cell loss and increased iron in the substantia nigra (SN) characterize Parkinson's disease (PD), with cerebellar involvement increasingly recognized, particularly in motor compensation and levodopa-induced dyskinesia (LID) development. Because the red nucleus (RN) mediates cerebellar circuitry, we hypothesized that RN iron changes might reflect cerebellum-related compensation, and/or the intrinsic capacity for LID development. We acquired high resolution magnetic resonance images from 23 control and 38 PD subjects (12 with PD and history of LID [PD+DYS]) and 26 with PD and no history of LID (PD-DYS). Iron content was estimated from bilateral RN and SN transverse relaxation rates (R2*). PD subjects overall displayed higher R2* values in both the SN and RN. RN R2* values correlated with off-drug Unified Parkinson's Disease Rating Scale-motor scores, but not disease duration or drug dosage. RN R2* values were significantly higher in PD+DYS compared with control and PD-DYS subjects; control and PD-DYS subjects did not differ. The association of higher RN iron content with PD-related dyskinesia suggests increased iron content is involved in, or reflects, greater cerebellar compensatory capacity and thus increased likelihood of LID development.

AB - Dopamine cell loss and increased iron in the substantia nigra (SN) characterize Parkinson's disease (PD), with cerebellar involvement increasingly recognized, particularly in motor compensation and levodopa-induced dyskinesia (LID) development. Because the red nucleus (RN) mediates cerebellar circuitry, we hypothesized that RN iron changes might reflect cerebellum-related compensation, and/or the intrinsic capacity for LID development. We acquired high resolution magnetic resonance images from 23 control and 38 PD subjects (12 with PD and history of LID [PD+DYS]) and 26 with PD and no history of LID (PD-DYS). Iron content was estimated from bilateral RN and SN transverse relaxation rates (R2*). PD subjects overall displayed higher R2* values in both the SN and RN. RN R2* values correlated with off-drug Unified Parkinson's Disease Rating Scale-motor scores, but not disease duration or drug dosage. RN R2* values were significantly higher in PD+DYS compared with control and PD-DYS subjects; control and PD-DYS subjects did not differ. The association of higher RN iron content with PD-related dyskinesia suggests increased iron content is involved in, or reflects, greater cerebellar compensatory capacity and thus increased likelihood of LID development.

UR - http://www.scopus.com/inward/record.url?scp=84873469778&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873469778&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2012.10.025

DO - 10.1016/j.neurobiolaging.2012.10.025

M3 - Article

C2 - 23177595

AN - SCOPUS:84873469778

VL - 34

SP - 1497

EP - 1503

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 5

ER -