Higher-order folding of heterochromatin: Protein bridges span the nucleosome arrays

Research output: Contribution to journalShort survey

19 Citations (Scopus)

Abstract

In interphase eukaryotic nuclei, chromatin is divided into two morphologically distinct types known as heterochromatin and euchromatin. It has been long suggested that the two types of chromatin differ at the level of higher-order folding. Recent studies have revealed the features of chromatin 3D architecture that distinguish the higher-order folding of repressed and active chromatin and have identified chromosomal proteins and their modifications associated with these structural transitions. This review discusses the molecular and structural determinants of chromatin higher-order folding in relation to mechanism(s) of heterochromatin formation and genetic silencing during cell differentiation and tissue development.

Original languageEnglish (US)
Pages (from-to)227-241
Number of pages15
JournalBiochemistry and Cell Biology
Volume79
Issue number3
DOIs
StatePublished - Jan 1 2001

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Heterochromatin
Nucleosomes
Protein Folding
Chromatin
Proteins
Euchromatin
Interphase
Cell Differentiation
Tissue

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

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abstract = "In interphase eukaryotic nuclei, chromatin is divided into two morphologically distinct types known as heterochromatin and euchromatin. It has been long suggested that the two types of chromatin differ at the level of higher-order folding. Recent studies have revealed the features of chromatin 3D architecture that distinguish the higher-order folding of repressed and active chromatin and have identified chromosomal proteins and their modifications associated with these structural transitions. This review discusses the molecular and structural determinants of chromatin higher-order folding in relation to mechanism(s) of heterochromatin formation and genetic silencing during cell differentiation and tissue development.",
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Higher-order folding of heterochromatin : Protein bridges span the nucleosome arrays. / Grigoryev, Sergei.

In: Biochemistry and Cell Biology, Vol. 79, No. 3, 01.01.2001, p. 227-241.

Research output: Contribution to journalShort survey

TY - JOUR

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T2 - Protein bridges span the nucleosome arrays

AU - Grigoryev, Sergei

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AB - In interphase eukaryotic nuclei, chromatin is divided into two morphologically distinct types known as heterochromatin and euchromatin. It has been long suggested that the two types of chromatin differ at the level of higher-order folding. Recent studies have revealed the features of chromatin 3D architecture that distinguish the higher-order folding of repressed and active chromatin and have identified chromosomal proteins and their modifications associated with these structural transitions. This review discusses the molecular and structural determinants of chromatin higher-order folding in relation to mechanism(s) of heterochromatin formation and genetic silencing during cell differentiation and tissue development.

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