The design and testing of an origami-based bellows for microgravity drilling is described. The potential benefits of an origami-based solution created an opportunity for application on NASA’s Asteroid Redirect Mission (ARM) to protect sensitive parts from debris. Origami-based bellows were designed to fit spatial limitations and meet needed compression ratios. Designs have demonstrated high mass reductions, improved stroke length, greatly decreased stowed volume, improved flexibility, and reduced reaction forces in comparison with traditional metal bellows. A nylon-reinforced polyvinyl fluoride based bellows with an aramid fiber stitched seam is well suited for debris containment in space conditions. Various epoxies maintained an adequate bond with polyvinyl fluoride below expected environmental temperature for bellows mounting. Asymmetric compression of the bellows occurs at extreme low temperatures and is preventable by balancing stiffness within the structure.