Highly Pathogenic Avian Influenza Virus A/H5N1 Infection in Vaccinated Meat Duck Flocks in the Mekong Delta of Vietnam

N. V. Cuong, V. N.T. Truc, N. T. Nhung, T. T. Thanh, T. T.B. Chieu, T. Q. Hieu, N. T. Men, H. H. Mai, H. T. Chi, M. F. Boni, H. R. van Doorn, G. E. Thwaites, J. J. Carrique-Mas, N. T. Hoa

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We investigated episodes of suspected highly pathogenic avian influenza (HPAI)-like illness among 12 meat duck flocks in two districts in Tien Giang province (Mekong Delta, Vietnam) in November 2013. In total, duck samples from 8 of 12 farms tested positive for HPAI virus subtype A/haemagglutinin 5 and neuraminidase 1 (H5N1) by real-time RT-PCR. Sequencing results confirmed clade of 2.3.2.1.c as the cause of the outbreaks. Most (7/8) laboratory-confirmed positive flocks had been vaccinated with inactivated HPAI H5N1 clade 2.3.4 vaccines <6 days prior to onset of clinical signs. A review of vaccination data in relation to estimated production in the area suggested that vaccination efforts were biased towards larger flocks and that vaccination coverage was low [21.2% ducks vaccinated with two shots (range by district 7.4-34.9%)]. The low-coverage data, the experimental evidence of lack of cross-protection conferred by the currently used vaccines based on clade 2.3.4 together with the short lifespan of meat duck flocks (60-70 days), suggest that vaccination is not likely to be effective as a tool for control of H5N1 infection in meat duck flocks in the area.

Original languageEnglish (US)
Pages (from-to)127-135
Number of pages9
JournalTransboundary and Emerging Diseases
Volume63
Issue number2
DOIs
StatePublished - Apr 1 2016

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duck meat
sialidase
Ducks
Vietnam
Neuraminidase
hemagglutinins
Influenza A virus
Meat
flocks
Vaccination
vaccination
Infection
Influenza in Birds
infection
Hemagglutinins
avian influenza
ducks
Vaccines
Cross Protection
vaccines

All Science Journal Classification (ASJC) codes

  • Immunology and Microbiology(all)
  • veterinary(all)

Cite this

Cuong, N. V., Truc, V. N. T., Nhung, N. T., Thanh, T. T., Chieu, T. T. B., Hieu, T. Q., ... Hoa, N. T. (2016). Highly Pathogenic Avian Influenza Virus A/H5N1 Infection in Vaccinated Meat Duck Flocks in the Mekong Delta of Vietnam. Transboundary and Emerging Diseases, 63(2), 127-135. https://doi.org/10.1111/tbed.12470
Cuong, N. V. ; Truc, V. N.T. ; Nhung, N. T. ; Thanh, T. T. ; Chieu, T. T.B. ; Hieu, T. Q. ; Men, N. T. ; Mai, H. H. ; Chi, H. T. ; Boni, M. F. ; van Doorn, H. R. ; Thwaites, G. E. ; Carrique-Mas, J. J. ; Hoa, N. T. / Highly Pathogenic Avian Influenza Virus A/H5N1 Infection in Vaccinated Meat Duck Flocks in the Mekong Delta of Vietnam. In: Transboundary and Emerging Diseases. 2016 ; Vol. 63, No. 2. pp. 127-135.
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abstract = "We investigated episodes of suspected highly pathogenic avian influenza (HPAI)-like illness among 12 meat duck flocks in two districts in Tien Giang province (Mekong Delta, Vietnam) in November 2013. In total, duck samples from 8 of 12 farms tested positive for HPAI virus subtype A/haemagglutinin 5 and neuraminidase 1 (H5N1) by real-time RT-PCR. Sequencing results confirmed clade of 2.3.2.1.c as the cause of the outbreaks. Most (7/8) laboratory-confirmed positive flocks had been vaccinated with inactivated HPAI H5N1 clade 2.3.4 vaccines <6 days prior to onset of clinical signs. A review of vaccination data in relation to estimated production in the area suggested that vaccination efforts were biased towards larger flocks and that vaccination coverage was low [21.2{\%} ducks vaccinated with two shots (range by district 7.4-34.9{\%})]. The low-coverage data, the experimental evidence of lack of cross-protection conferred by the currently used vaccines based on clade 2.3.4 together with the short lifespan of meat duck flocks (60-70 days), suggest that vaccination is not likely to be effective as a tool for control of H5N1 infection in meat duck flocks in the area.",
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Cuong, NV, Truc, VNT, Nhung, NT, Thanh, TT, Chieu, TTB, Hieu, TQ, Men, NT, Mai, HH, Chi, HT, Boni, MF, van Doorn, HR, Thwaites, GE, Carrique-Mas, JJ & Hoa, NT 2016, 'Highly Pathogenic Avian Influenza Virus A/H5N1 Infection in Vaccinated Meat Duck Flocks in the Mekong Delta of Vietnam', Transboundary and Emerging Diseases, vol. 63, no. 2, pp. 127-135. https://doi.org/10.1111/tbed.12470

Highly Pathogenic Avian Influenza Virus A/H5N1 Infection in Vaccinated Meat Duck Flocks in the Mekong Delta of Vietnam. / Cuong, N. V.; Truc, V. N.T.; Nhung, N. T.; Thanh, T. T.; Chieu, T. T.B.; Hieu, T. Q.; Men, N. T.; Mai, H. H.; Chi, H. T.; Boni, M. F.; van Doorn, H. R.; Thwaites, G. E.; Carrique-Mas, J. J.; Hoa, N. T.

In: Transboundary and Emerging Diseases, Vol. 63, No. 2, 01.04.2016, p. 127-135.

Research output: Contribution to journalArticle

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T1 - Highly Pathogenic Avian Influenza Virus A/H5N1 Infection in Vaccinated Meat Duck Flocks in the Mekong Delta of Vietnam

AU - Cuong, N. V.

AU - Truc, V. N.T.

AU - Nhung, N. T.

AU - Thanh, T. T.

AU - Chieu, T. T.B.

AU - Hieu, T. Q.

AU - Men, N. T.

AU - Mai, H. H.

AU - Chi, H. T.

AU - Boni, M. F.

AU - van Doorn, H. R.

AU - Thwaites, G. E.

AU - Carrique-Mas, J. J.

AU - Hoa, N. T.

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N2 - We investigated episodes of suspected highly pathogenic avian influenza (HPAI)-like illness among 12 meat duck flocks in two districts in Tien Giang province (Mekong Delta, Vietnam) in November 2013. In total, duck samples from 8 of 12 farms tested positive for HPAI virus subtype A/haemagglutinin 5 and neuraminidase 1 (H5N1) by real-time RT-PCR. Sequencing results confirmed clade of 2.3.2.1.c as the cause of the outbreaks. Most (7/8) laboratory-confirmed positive flocks had been vaccinated with inactivated HPAI H5N1 clade 2.3.4 vaccines <6 days prior to onset of clinical signs. A review of vaccination data in relation to estimated production in the area suggested that vaccination efforts were biased towards larger flocks and that vaccination coverage was low [21.2% ducks vaccinated with two shots (range by district 7.4-34.9%)]. The low-coverage data, the experimental evidence of lack of cross-protection conferred by the currently used vaccines based on clade 2.3.4 together with the short lifespan of meat duck flocks (60-70 days), suggest that vaccination is not likely to be effective as a tool for control of H5N1 infection in meat duck flocks in the area.

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