Highly permeable artificial water channels that can self-assemble into two-dimensional arrays

Yue Xiao Shen, Wen Si, Mustafa Erbakan, Karl Decker, Rita De Zorzi, Patrick O. Saboe, You Jung Kang, Sheereen Majd, Peter J. Butler, Thomas Walz, Aleksei Aksimentiev, Jun Li Hou, Manish Kumar, David A. Weitz

Research output: Contribution to journalArticle

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Abstract

Bioinspired artificial water channels aim to combine the high permeability and selectivity of biological aquaporin (AQP) water channels with chemical stability. Here, we carefully characterized a class of artificial water channels, peptide-appended pillar[5]arenes (PAPs). The average single-channel osmotic water permeability for PAPs is 1.0(±0.3) × 10-14 cm3/s or 3.5(±1.0) × 108 water molecules per s, which is in the range of AQPs (3.440.3 × 108 water molecules per s) and their current synthetic analogs, carbon nanotubes (CNTs, 9.0 × 108 water molecules per s). This permeability is an order of magnitude higher than first-generation artificial water channels (20 to 107 water molecules per s). Furthermore, within lipid bilayers, PAP channels can self-assemble into 2D arrays. Relevant to permeable membrane design, the pore density of PAP channel arrays (2.6 × 105 pores per μm2) is two orders of magnitude higher than that of CNT membranes (0.12.5 × 103 pores per μm2). PAP channels thus combine the advantages of biological channels and CNTs and improve upon them through their relatively simple synthesis, chemical stability, and propensity to form arrays.

Original languageEnglish (US)
Pages (from-to)9810-9815
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume112
Issue number32
DOIs
StatePublished - Aug 11 2015

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Aquaporins
Permeability
Water
Carbon Nanotubes
Membranes
Lipid Bilayers
Peptides

All Science Journal Classification (ASJC) codes

  • General

Cite this

Shen, Yue Xiao ; Si, Wen ; Erbakan, Mustafa ; Decker, Karl ; De Zorzi, Rita ; Saboe, Patrick O. ; Kang, You Jung ; Majd, Sheereen ; Butler, Peter J. ; Walz, Thomas ; Aksimentiev, Aleksei ; Hou, Jun Li ; Kumar, Manish ; Weitz, David A. / Highly permeable artificial water channels that can self-assemble into two-dimensional arrays. In: Proceedings of the National Academy of Sciences of the United States of America. 2015 ; Vol. 112, No. 32. pp. 9810-9815.
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abstract = "Bioinspired artificial water channels aim to combine the high permeability and selectivity of biological aquaporin (AQP) water channels with chemical stability. Here, we carefully characterized a class of artificial water channels, peptide-appended pillar[5]arenes (PAPs). The average single-channel osmotic water permeability for PAPs is 1.0(±0.3) × 10-14 cm3/s or 3.5(±1.0) × 108 water molecules per s, which is in the range of AQPs (3.440.3 × 108 water molecules per s) and their current synthetic analogs, carbon nanotubes (CNTs, 9.0 × 108 water molecules per s). This permeability is an order of magnitude higher than first-generation artificial water channels (20 to 107 water molecules per s). Furthermore, within lipid bilayers, PAP channels can self-assemble into 2D arrays. Relevant to permeable membrane design, the pore density of PAP channel arrays (2.6 × 105 pores per μm2) is two orders of magnitude higher than that of CNT membranes (0.12.5 × 103 pores per μm2). PAP channels thus combine the advantages of biological channels and CNTs and improve upon them through their relatively simple synthesis, chemical stability, and propensity to form arrays.",
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Shen, YX, Si, W, Erbakan, M, Decker, K, De Zorzi, R, Saboe, PO, Kang, YJ, Majd, S, Butler, PJ, Walz, T, Aksimentiev, A, Hou, JL, Kumar, M & Weitz, DA 2015, 'Highly permeable artificial water channels that can self-assemble into two-dimensional arrays', Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 32, pp. 9810-9815. https://doi.org/10.1073/pnas.1508575112

Highly permeable artificial water channels that can self-assemble into two-dimensional arrays. / Shen, Yue Xiao; Si, Wen; Erbakan, Mustafa; Decker, Karl; De Zorzi, Rita; Saboe, Patrick O.; Kang, You Jung; Majd, Sheereen; Butler, Peter J.; Walz, Thomas; Aksimentiev, Aleksei; Hou, Jun Li; Kumar, Manish; Weitz, David A.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, No. 32, 11.08.2015, p. 9810-9815.

Research output: Contribution to journalArticle

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T1 - Highly permeable artificial water channels that can self-assemble into two-dimensional arrays

AU - Shen, Yue Xiao

AU - Si, Wen

AU - Erbakan, Mustafa

AU - Decker, Karl

AU - De Zorzi, Rita

AU - Saboe, Patrick O.

AU - Kang, You Jung

AU - Majd, Sheereen

AU - Butler, Peter J.

AU - Walz, Thomas

AU - Aksimentiev, Aleksei

AU - Hou, Jun Li

AU - Kumar, Manish

AU - Weitz, David A.

PY - 2015/8/11

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N2 - Bioinspired artificial water channels aim to combine the high permeability and selectivity of biological aquaporin (AQP) water channels with chemical stability. Here, we carefully characterized a class of artificial water channels, peptide-appended pillar[5]arenes (PAPs). The average single-channel osmotic water permeability for PAPs is 1.0(±0.3) × 10-14 cm3/s or 3.5(±1.0) × 108 water molecules per s, which is in the range of AQPs (3.440.3 × 108 water molecules per s) and their current synthetic analogs, carbon nanotubes (CNTs, 9.0 × 108 water molecules per s). This permeability is an order of magnitude higher than first-generation artificial water channels (20 to 107 water molecules per s). Furthermore, within lipid bilayers, PAP channels can self-assemble into 2D arrays. Relevant to permeable membrane design, the pore density of PAP channel arrays (2.6 × 105 pores per μm2) is two orders of magnitude higher than that of CNT membranes (0.12.5 × 103 pores per μm2). PAP channels thus combine the advantages of biological channels and CNTs and improve upon them through their relatively simple synthesis, chemical stability, and propensity to form arrays.

AB - Bioinspired artificial water channels aim to combine the high permeability and selectivity of biological aquaporin (AQP) water channels with chemical stability. Here, we carefully characterized a class of artificial water channels, peptide-appended pillar[5]arenes (PAPs). The average single-channel osmotic water permeability for PAPs is 1.0(±0.3) × 10-14 cm3/s or 3.5(±1.0) × 108 water molecules per s, which is in the range of AQPs (3.440.3 × 108 water molecules per s) and their current synthetic analogs, carbon nanotubes (CNTs, 9.0 × 108 water molecules per s). This permeability is an order of magnitude higher than first-generation artificial water channels (20 to 107 water molecules per s). Furthermore, within lipid bilayers, PAP channels can self-assemble into 2D arrays. Relevant to permeable membrane design, the pore density of PAP channel arrays (2.6 × 105 pores per μm2) is two orders of magnitude higher than that of CNT membranes (0.12.5 × 103 pores per μm2). PAP channels thus combine the advantages of biological channels and CNTs and improve upon them through their relatively simple synthesis, chemical stability, and propensity to form arrays.

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