Highly Reactive Free Radicals in Electronic Cigarette Aerosols

Reema Goel, Erwann Durand, Neil Trushin, Bogdan Prokopczyk, Jonathan Foulds, Ryan J. Elias, John P. Richie

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Electronic cigarette (EC) usage has increased exponentially, but limited data are available on its potential harmful effects. We tested for the presence of reactive, short-lived free radicals in EC aerosols by electron paramagnetic resonance spectroscopy (EPR) using the spin-trap phenyl-N-tert-butylnitrone (PBN). Radicals were detected in aerosols from all ECs and eliquids tested (2.5 × 1013 to 10.3 × 1013 radicals per puff at 3.3 V) and from eliquid solvents propylene glycol and glycerol and from "dry puffing". These results demonstrate, for the first time, the production of highly oxidizing free radicals from ECs which may present a potential toxicological risk to EC users.

Original languageEnglish (US)
Pages (from-to)1675-1677
Number of pages3
JournalChemical research in toxicology
Volume28
Issue number9
DOIs
StatePublished - Sep 21 2015

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Aerosols
Tobacco Products
Free Radicals
Propylene Glycol
Electron Spin Resonance Spectroscopy
Glycerol
Toxicology
Paramagnetic resonance
Spectrum Analysis
Spectroscopy
Electronic Cigarettes

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

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abstract = "Electronic cigarette (EC) usage has increased exponentially, but limited data are available on its potential harmful effects. We tested for the presence of reactive, short-lived free radicals in EC aerosols by electron paramagnetic resonance spectroscopy (EPR) using the spin-trap phenyl-N-tert-butylnitrone (PBN). Radicals were detected in aerosols from all ECs and eliquids tested (2.5 × 1013 to 10.3 × 1013 radicals per puff at 3.3 V) and from eliquid solvents propylene glycol and glycerol and from {"}dry puffing{"}. These results demonstrate, for the first time, the production of highly oxidizing free radicals from ECs which may present a potential toxicological risk to EC users.",
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Highly Reactive Free Radicals in Electronic Cigarette Aerosols. / Goel, Reema; Durand, Erwann; Trushin, Neil; Prokopczyk, Bogdan; Foulds, Jonathan; Elias, Ryan J.; Richie, John P.

In: Chemical research in toxicology, Vol. 28, No. 9, 21.09.2015, p. 1675-1677.

Research output: Contribution to journalArticle

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AU - Goel, Reema

AU - Durand, Erwann

AU - Trushin, Neil

AU - Prokopczyk, Bogdan

AU - Foulds, Jonathan

AU - Elias, Ryan J.

AU - Richie, John P.

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