Highly sensitive detection of nanoparticles with a self-referenced and self-heterodyned whispering-gallery Raman microlaser

Sahin Ozdemir, Jiangang Zhu, Xu Yang, Bo Peng, Huzeyfe Yilmaz, Lina He, Faraz Monifi, Steven He Huang, Gui Lu Long, Lan Yang

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

Optical whispering-gallery-mode resonators (WGMRs) have emerged as promising platforms for label-free detection of nano-objects. The ultimate sensitivity of WGMRs is determined by the strength of the light.matter interaction quantified by quality factor/mode volume, Q/V, and the resolution is determined by Q. To date, to improve sensitivity and precision of detection either WGMRs have been doped with rare-earth ions to compensate losses and increase Q or plasmonic resonances have been exploited for their superior field confinement and lower V. Here, we demonstrate, for the first time to our knowledge, enhanced detection of single-nanoparticleinduced mode splitting in a silica WGMR via Raman gain-assisted loss compensation and WGM Raman microlaser. In particular, the use of the Raman microlaser provides a dopant-free, self-referenced, and self-heterodyned scheme with a detection limit ultimately determined by the thermorefractive noise. Notably, we detected and counted individual nanoparticles with polarizabilities down to 3.82 × 10-6μm3by monitoring a heterodyne beatnote signal. This level of sensitivity is achieved without exploiting plasmonic effects, external references, or active stabilization and frequency locking. Single nanoparticles are detected one at a time; however, their characterization by size or polarizability requires ensemble measurements and statistical averaging. This dopant-free scheme retains the inherited biocompatibility of silica and could find widespread use for sensing in biological media. The Raman laser and operation band of the sensor can be tailored for the specific sensing environment and the properties of the targeted materials by changing the pump laser wavelength. This scheme also opens the possibility of using intrinsic Raman or parametric gain for loss compensation in other systems where dissipation hinders progress and limits applications.

Original languageEnglish (US)
Pages (from-to)E3836-E3844
JournalProceedings of the National Academy of Sciences of the United States of America
Volume111
Issue number37
DOIs
StatePublished - Sep 16 2014

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whispering gallery modes
nanoparticles
resonators
sensitivity
silicon dioxide
Raman lasers
biocompatibility
locking
Q factors
rare earth elements
dissipation
platforms
stabilization
pumps
sensors
wavelengths
lasers
ions
interactions

All Science Journal Classification (ASJC) codes

  • General

Cite this

Ozdemir, Sahin ; Zhu, Jiangang ; Yang, Xu ; Peng, Bo ; Yilmaz, Huzeyfe ; He, Lina ; Monifi, Faraz ; Huang, Steven He ; Long, Gui Lu ; Yang, Lan. / Highly sensitive detection of nanoparticles with a self-referenced and self-heterodyned whispering-gallery Raman microlaser. In: Proceedings of the National Academy of Sciences of the United States of America. 2014 ; Vol. 111, No. 37. pp. E3836-E3844.
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Highly sensitive detection of nanoparticles with a self-referenced and self-heterodyned whispering-gallery Raman microlaser. / Ozdemir, Sahin; Zhu, Jiangang; Yang, Xu; Peng, Bo; Yilmaz, Huzeyfe; He, Lina; Monifi, Faraz; Huang, Steven He; Long, Gui Lu; Yang, Lan.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, No. 37, 16.09.2014, p. E3836-E3844.

Research output: Contribution to journalArticle

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AU - Ozdemir, Sahin

AU - Zhu, Jiangang

AU - Yang, Xu

AU - Peng, Bo

AU - Yilmaz, Huzeyfe

AU - He, Lina

AU - Monifi, Faraz

AU - Huang, Steven He

AU - Long, Gui Lu

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