Hirschsprung's enterocolitis, prostaglandins, and response to cholestyramine

John D. Lloyd-Still, Laurence M. Demers

Research output: Contribution to journalArticle

20 Scopus citations


• An infant with Hirschsprung’s enterocolitis developed a fulminant secretory diarrhea unresponsive to all conventional therapy until cholestyramine was administered. A 12-fold decrease in prostaglandin E (PGE) levels in the colostomy fluid was documented in response to cholestyramine therapy. It is postulated that increased PGE activity, errterotoxin, and bile acid malabsorption may be involved in the enterocolitis of Hirschsprung's disease.

Original languageEnglish (US)
Pages (from-to)417-418
Number of pages2
JournalJournal of pediatric surgery
Issue number4
Publication statusPublished - Jan 1 1978


All Science Journal Classification (ASJC) codes

  • Surgery
  • Pediatrics, Perinatology, and Child Health

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