TY - JOUR
T1 - Hirschsprung's enterocolitis, prostaglandins, and response to cholestyramine
AU - Lloyd-Still, John D.
AU - Demers, Laurence M.
PY - 1978/1/1
Y1 - 1978/1/1
N2 - • An infant with Hirschsprung’s enterocolitis developed a fulminant secretory diarrhea unresponsive to all conventional therapy until cholestyramine was administered. A 12-fold decrease in prostaglandin E (PGE) levels in the colostomy fluid was documented in response to cholestyramine therapy. It is postulated that increased PGE activity, errterotoxin, and bile acid malabsorption may be involved in the enterocolitis of Hirschsprung's disease.
AB - • An infant with Hirschsprung’s enterocolitis developed a fulminant secretory diarrhea unresponsive to all conventional therapy until cholestyramine was administered. A 12-fold decrease in prostaglandin E (PGE) levels in the colostomy fluid was documented in response to cholestyramine therapy. It is postulated that increased PGE activity, errterotoxin, and bile acid malabsorption may be involved in the enterocolitis of Hirschsprung's disease.
UR - http://www.scopus.com/inward/record.url?scp=0017816476&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017816476&partnerID=8YFLogxK
U2 - 10.1016/S0022-3468(78)80467-9
DO - 10.1016/S0022-3468(78)80467-9
M3 - Article
C2 - 682092
AN - SCOPUS:0017816476
SN - 0022-3468
VL - 13
SP - 417
EP - 418
JO - Journal of Pediatric Surgery
JF - Journal of Pediatric Surgery
IS - 4
ER -
