Histiocytic erythema multiforme

Anita Sebastian, Connor Patterson, Andrea Zaenglein, Michael Ioffreda, Klaus Helm

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Erythema multiforme is histologically characterized by liquefactive degeneration along the dermal-epidermal junction, necrotic keratinocytes and a lymphocytic infiltrate. We report a 10-year-old boy with recurrent erythema multiforme major of undetermined etiology with unusual histologic findings. A skin biopsy taken at day 2 of his eruption revealed histologic features otherwise characteristic of erythema multiforme, but mediated instead by a CD68-positive infiltrate, resembling cutaneous Kikuchi's disease. To the best of our knowledge this is the first reported case of 'histiocytic' erythema multiforme.

Original languageEnglish (US)
Pages (from-to)1323-1325
Number of pages3
JournalJournal of Cutaneous Pathology
Issue number12
StatePublished - Dec 2009

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology


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