Histiocytic sarcoma with two immunohistopathologically distinct populations

Kanako Wakahashi, Manabu Shimoyama, Yoshio Katayama, Kentaro Minagawa, Kenji Yoshida, Ryohei Sasaki, Shunji Nakayama, Hiroshi Yokozaki, Emmy Yanagita, Tomoo Itoh, Yoshitake Hayashi, Toshimitsu Matsui

Research output: Contribution to journalArticle

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Abstract

This report is a case of histiocytic sarcoma (HS), in which tumor cells consist of two immunohistopathologically distinct populations (A) oval CD68+lysozyme+CD163- cells and (B) abundant cytoplasm or spindle-shaped CD68+lysozyme-CD163+ cells. Cervical lymph node was infiltrated mainly by population (A), where chemotherapy was quite effective. On the other hand, vast majority of infiltrated tumor cells in the hilar lymph node belonged to population (B), in which the cells were resistant to chemo-radiotherapy. Considering the poor prognosis of HS, the expression of CD163 could be a marker for resistance to chemo-radiotherapy. It is also notable that CD163-negative stage of HS may exist and still be reactive for the treatment.

Original languageEnglish (US)
Pages (from-to)642-646
Number of pages5
JournalInternational journal of hematology
Volume92
Issue number4
DOIs
StatePublished - Nov 1 2010

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Histiocytic Sarcoma
Population
Muramidase
Radiotherapy
Lymph Nodes
Neoplasms
Cytoplasm
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Wakahashi, K., Shimoyama, M., Katayama, Y., Minagawa, K., Yoshida, K., Sasaki, R., ... Matsui, T. (2010). Histiocytic sarcoma with two immunohistopathologically distinct populations. International journal of hematology, 92(4), 642-646. https://doi.org/10.1007/s12185-010-0699-1
Wakahashi, Kanako ; Shimoyama, Manabu ; Katayama, Yoshio ; Minagawa, Kentaro ; Yoshida, Kenji ; Sasaki, Ryohei ; Nakayama, Shunji ; Yokozaki, Hiroshi ; Yanagita, Emmy ; Itoh, Tomoo ; Hayashi, Yoshitake ; Matsui, Toshimitsu. / Histiocytic sarcoma with two immunohistopathologically distinct populations. In: International journal of hematology. 2010 ; Vol. 92, No. 4. pp. 642-646.
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author = "Kanako Wakahashi and Manabu Shimoyama and Yoshio Katayama and Kentaro Minagawa and Kenji Yoshida and Ryohei Sasaki and Shunji Nakayama and Hiroshi Yokozaki and Emmy Yanagita and Tomoo Itoh and Yoshitake Hayashi and Toshimitsu Matsui",
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Wakahashi, K, Shimoyama, M, Katayama, Y, Minagawa, K, Yoshida, K, Sasaki, R, Nakayama, S, Yokozaki, H, Yanagita, E, Itoh, T, Hayashi, Y & Matsui, T 2010, 'Histiocytic sarcoma with two immunohistopathologically distinct populations', International journal of hematology, vol. 92, no. 4, pp. 642-646. https://doi.org/10.1007/s12185-010-0699-1

Histiocytic sarcoma with two immunohistopathologically distinct populations. / Wakahashi, Kanako; Shimoyama, Manabu; Katayama, Yoshio; Minagawa, Kentaro; Yoshida, Kenji; Sasaki, Ryohei; Nakayama, Shunji; Yokozaki, Hiroshi; Yanagita, Emmy; Itoh, Tomoo; Hayashi, Yoshitake; Matsui, Toshimitsu.

In: International journal of hematology, Vol. 92, No. 4, 01.11.2010, p. 642-646.

Research output: Contribution to journalArticle

TY - JOUR

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AU - Wakahashi, Kanako

AU - Shimoyama, Manabu

AU - Katayama, Yoshio

AU - Minagawa, Kentaro

AU - Yoshida, Kenji

AU - Sasaki, Ryohei

AU - Nakayama, Shunji

AU - Yokozaki, Hiroshi

AU - Yanagita, Emmy

AU - Itoh, Tomoo

AU - Hayashi, Yoshitake

AU - Matsui, Toshimitsu

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AB - This report is a case of histiocytic sarcoma (HS), in which tumor cells consist of two immunohistopathologically distinct populations (A) oval CD68+lysozyme+CD163- cells and (B) abundant cytoplasm or spindle-shaped CD68+lysozyme-CD163+ cells. Cervical lymph node was infiltrated mainly by population (A), where chemotherapy was quite effective. On the other hand, vast majority of infiltrated tumor cells in the hilar lymph node belonged to population (B), in which the cells were resistant to chemo-radiotherapy. Considering the poor prognosis of HS, the expression of CD163 could be a marker for resistance to chemo-radiotherapy. It is also notable that CD163-negative stage of HS may exist and still be reactive for the treatment.

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