Abstract

Objective: Olfactory dysfunction is the most common pre-motor symptom in Parkinson's disease (PD), and smoking is known to be associated with lower risk of PD. This study tested the hypothesis that smoking is associated with better olfaction in PD. Methods: Smoking history was obtained from 76 PD subjects (22 with a history of smoking [smokers], 54 who never smoked [nonsmokers]), and 70 controls (17 smokers, 53 nonsmokers). Olfaction was assessed using the 40-item University of Pennsylvania Smell Identification Test (UPSIT). The olfactory scores between groups and subgroups were compared using analysis of covariance with adjustment for age, gender, and monoamine oxidase B (MAO-B) inhibitor usage. Results: Overall the olfactory score was lower in PD compared with controls (olfactory scores: 21.5 vs. 33.5, P<0.0001). Among controls, there was no significant difference in olfaction between smokers and nonsmokers (olfactory scores, 33.2 vs. 34.2; P=0.95). Among PD subjects, however, smokers scored significantly better regarding olfaction compared with nonsmokers (olfactory scores: 24.4 vs. 19.9, P=0.02). Conclusions: These data suggest that a history of smoking is associated with better olfaction among PD patients. The finding may be related to why smoking may be protective against PD. Further studies are needed to confirm this finding and investigate the underlying mechanisms.

Original languageEnglish (US)
Pages (from-to)1069-1074
Number of pages6
JournalMovement Disorders
Volume29
Issue number8
DOIs
StatePublished - Jul 2014

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Smell
Parkinson Disease
Smoking
Monoamine Oxidase Inhibitors
Monoamine Oxidase
History

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Lucassen, Elisabeth B. ; Sterling, Nicholas W. ; Lee, Eun Young ; Chen, Honglei ; Lewis, Mechelle M. ; Kong, Lan ; Huang, Xuemei. / History of smoking and olfaction in Parkinson's disease. In: Movement Disorders. 2014 ; Vol. 29, No. 8. pp. 1069-1074.
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abstract = "Objective: Olfactory dysfunction is the most common pre-motor symptom in Parkinson's disease (PD), and smoking is known to be associated with lower risk of PD. This study tested the hypothesis that smoking is associated with better olfaction in PD. Methods: Smoking history was obtained from 76 PD subjects (22 with a history of smoking [smokers], 54 who never smoked [nonsmokers]), and 70 controls (17 smokers, 53 nonsmokers). Olfaction was assessed using the 40-item University of Pennsylvania Smell Identification Test (UPSIT). The olfactory scores between groups and subgroups were compared using analysis of covariance with adjustment for age, gender, and monoamine oxidase B (MAO-B) inhibitor usage. Results: Overall the olfactory score was lower in PD compared with controls (olfactory scores: 21.5 vs. 33.5, P<0.0001). Among controls, there was no significant difference in olfaction between smokers and nonsmokers (olfactory scores, 33.2 vs. 34.2; P=0.95). Among PD subjects, however, smokers scored significantly better regarding olfaction compared with nonsmokers (olfactory scores: 24.4 vs. 19.9, P=0.02). Conclusions: These data suggest that a history of smoking is associated with better olfaction among PD patients. The finding may be related to why smoking may be protective against PD. Further studies are needed to confirm this finding and investigate the underlying mechanisms.",
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History of smoking and olfaction in Parkinson's disease. / Lucassen, Elisabeth B.; Sterling, Nicholas W.; Lee, Eun Young; Chen, Honglei; Lewis, Mechelle M.; Kong, Lan; Huang, Xuemei.

In: Movement Disorders, Vol. 29, No. 8, 07.2014, p. 1069-1074.

Research output: Contribution to journalArticle

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T1 - History of smoking and olfaction in Parkinson's disease

AU - Lucassen, Elisabeth B.

AU - Sterling, Nicholas W.

AU - Lee, Eun Young

AU - Chen, Honglei

AU - Lewis, Mechelle M.

AU - Kong, Lan

AU - Huang, Xuemei

PY - 2014/7

Y1 - 2014/7

N2 - Objective: Olfactory dysfunction is the most common pre-motor symptom in Parkinson's disease (PD), and smoking is known to be associated with lower risk of PD. This study tested the hypothesis that smoking is associated with better olfaction in PD. Methods: Smoking history was obtained from 76 PD subjects (22 with a history of smoking [smokers], 54 who never smoked [nonsmokers]), and 70 controls (17 smokers, 53 nonsmokers). Olfaction was assessed using the 40-item University of Pennsylvania Smell Identification Test (UPSIT). The olfactory scores between groups and subgroups were compared using analysis of covariance with adjustment for age, gender, and monoamine oxidase B (MAO-B) inhibitor usage. Results: Overall the olfactory score was lower in PD compared with controls (olfactory scores: 21.5 vs. 33.5, P<0.0001). Among controls, there was no significant difference in olfaction between smokers and nonsmokers (olfactory scores, 33.2 vs. 34.2; P=0.95). Among PD subjects, however, smokers scored significantly better regarding olfaction compared with nonsmokers (olfactory scores: 24.4 vs. 19.9, P=0.02). Conclusions: These data suggest that a history of smoking is associated with better olfaction among PD patients. The finding may be related to why smoking may be protective against PD. Further studies are needed to confirm this finding and investigate the underlying mechanisms.

AB - Objective: Olfactory dysfunction is the most common pre-motor symptom in Parkinson's disease (PD), and smoking is known to be associated with lower risk of PD. This study tested the hypothesis that smoking is associated with better olfaction in PD. Methods: Smoking history was obtained from 76 PD subjects (22 with a history of smoking [smokers], 54 who never smoked [nonsmokers]), and 70 controls (17 smokers, 53 nonsmokers). Olfaction was assessed using the 40-item University of Pennsylvania Smell Identification Test (UPSIT). The olfactory scores between groups and subgroups were compared using analysis of covariance with adjustment for age, gender, and monoamine oxidase B (MAO-B) inhibitor usage. Results: Overall the olfactory score was lower in PD compared with controls (olfactory scores: 21.5 vs. 33.5, P<0.0001). Among controls, there was no significant difference in olfaction between smokers and nonsmokers (olfactory scores, 33.2 vs. 34.2; P=0.95). Among PD subjects, however, smokers scored significantly better regarding olfaction compared with nonsmokers (olfactory scores: 24.4 vs. 19.9, P=0.02). Conclusions: These data suggest that a history of smoking is associated with better olfaction among PD patients. The finding may be related to why smoking may be protective against PD. Further studies are needed to confirm this finding and investigate the underlying mechanisms.

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